diff --git a/devel/py-setuptools/Makefile b/devel/py-setuptools/Makefile
--- a/devel/py-setuptools/Makefile
+++ b/devel/py-setuptools/Makefile
@@ -1,31 +1,50 @@
 PORTNAME=	setuptools
-PORTVERSION=	63.1.0
-PORTREVISION=	3
+DISTVERSION=	80.9.0
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DIST_SUBDIR=	python
 
-PATCH_SITES=	https://github.com/pypa/${PORTNAME}/commit/
-PATCHFILES=	6653e747c3815b140156249205397ef3719581ee.patch:-p1
-
 # note: before committing a new major version, contact portmgr to
 # arrange for an experimental ports run. Untested commits may be
 # backed out.
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	Python packages installer
-WWW=		https://github.com/pypa/setuptools \
-		https://pypi.org/project/setuptools/
+WWW=		https://setuptools.pypa.io/
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}wheel044<0.46.0:devel/py-wheel044@${PY_FLAVOR}
+BUILD_DEPENDS=	${_CORE_DEPENDS}
+RUN_DEPENDS=	${_CORE_DEPENDS}
 
 USES=		cpe python
-USE_PYTHON=	allflavors autoplist concurrent pep517 # pytest to return later
-
 CPE_VENDOR=	python
+USE_PYTHON=	allflavors autoplist concurrent pep517 pytest
+
+_CORE_DEPENDS=	${PYTHON_PKGNAMEPREFIX}packaging>=24.2:devel/py-packaging@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}more-itertools>=8.8:devel/py-more-itertools@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}wheel>=0.43.0:devel/py-wheel@${PY_FLAVOR} \
+		${PY_TOMLI}
+
+# circular dependencies
+#_CORE_DEPENDS=	${PYTHON_PKGNAMEPREFIX}jaraco.text>=3.7:devel/py-jaraco.text@${PY_FLAVOR} \
+#		${PYTHON_PKGNAMEPREFIX}platformdirs>=4.2.2:devel/py-platformdirs@${PY_FLAVOR} \
+#		${PYTHON_PKGNAMEPREFIX}jaraco.functools>=4:devel/py-jaraco.functools@${PY_FLAVOR} \
+#		${PYTHON_PKGNAMEPREFIX}ruff>=0.7.0:devel/py-ruff@${PY_FLAVOR}
+
+# in devel/py-jaraco.text dependency chain via devel/py-inflect
+_CORE_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}typing-extensions>0:devel/py-typing-extensions@${PY_FLAVOR}
+
+# remove vendored packages of those already installed via pkg(8)
+_DIST_EXCLUDES=	packaging* \
+		more_itertools* \
+		wheel* \
+		importlib_metadata* \
+		tomli* \
+		typing_extensions* \
+		zipp*
+EXTRACT_AFTER_ARGS=	${_DIST_EXCLUDES:S,^,--exclude setuptools/_vendor/,}
 
 NO_ARCH=	yes
 
diff --git a/devel/py-setuptools/distinfo b/devel/py-setuptools/distinfo
--- a/devel/py-setuptools/distinfo
+++ b/devel/py-setuptools/distinfo
@@ -1,5 +1,3 @@
-TIMESTAMP = 1744292398
-SHA256 (python/setuptools-63.1.0.tar.gz) = 16923d366ced322712c71ccb97164d07472abeecd13f3a6c283f6d5d26722793
-SIZE (python/setuptools-63.1.0.tar.gz) = 2599380
-SHA256 (python/6653e747c3815b140156249205397ef3719581ee.patch) = fbdb0cdeee1d38829b73cadd95445815c9b5566b7e803b8bd39586f6d4afe077
-SIZE (python/6653e747c3815b140156249205397ef3719581ee.patch) = 1262
+TIMESTAMP = 1748364380
+SHA256 (python/setuptools-80.9.0.tar.gz) = f36b47402ecde768dbfafc46e8e4207b4360c654f1f3bb84475f0a28628fb19c
+SIZE (python/setuptools-80.9.0.tar.gz) = 1319958