diff --git a/lib/libusb/libusb10.c b/lib/libusb/libusb10.c
--- a/lib/libusb/libusb10.c
+++ b/lib/libusb/libusb10.c
@@ -624,7 +624,7 @@
 {
 	libusb_context *ctx = dev->ctx;
 	struct libusb20_device *pdev = dev->os_priv;
-	int err;
+	int fd, err;
 
 	if (devh == NULL)
 		return (LIBUSB_ERROR_INVALID_PARAM);
@@ -642,6 +642,19 @@
 		return (LIBUSB_ERROR_NO_MEM);
 	}
 
+	/*
+	 * Place an advisory lock on the device.
+	 * If this fails, some other process did so first.
+	 * Closing the device clears the lock.
+	 */
+	fd = libusb20_dev_get_fd(pdev);
+	err = flock(fd, LOCK_EX|LOCK_NB);
+	if (err) {
+		libusb20_dev_close(pdev);
+		libusb_unref_device(dev);
+		return (LIBUSB_ERROR_ACCESS);
+	}
+
 	/*
 	 * Clear the device gone flag, in case the device was opened
 	 * after a re-attach, to allow new transaction:
@@ -650,7 +663,7 @@
 	dev->device_is_gone = 0;
 	CTX_UNLOCK(ctx);
 
-	libusb10_add_pollfd(ctx, &dev->dev_poll, pdev, libusb20_dev_get_fd(pdev), POLLIN |
+	libusb10_add_pollfd(ctx, &dev->dev_poll, pdev, fd, POLLIN |
 	    POLLOUT | POLLRDNORM | POLLWRNORM);
 
 	/* make sure our event loop detects the new device */
@@ -670,6 +683,7 @@
 	struct LIBUSB20_DEVICE_DESC_DECODED *pdesc;
 	int i;
 	int j;
+	int ok;
 
 	ctx = GET_CONTEXT(ctx);
 	if (ctx == NULL)
@@ -693,8 +707,12 @@
 		 */
 		if (pdesc->idVendor == vendor_id &&
 		    pdesc->idProduct == product_id) {
-			libusb_open(devs[j], &pdev);
-			break;
+			ok = libusb_open(devs[j], &pdev);
+			/*
+			 *if this fails, try the next one.
+			 */
+			if (ok == 0)
+				break;
 		}
 	}