diff --git a/biology/libsedml/Makefile b/biology/libsedml/Makefile
index c979cd8bc72f..cb2c3d8df493 100644
--- a/biology/libsedml/Makefile
+++ b/biology/libsedml/Makefile
@@ -1,34 +1,39 @@
 PORTNAME=	libsedml
 DISTVERSIONPREFIX=	v
-DISTVERSION=	2.0.32
+DISTVERSION=	2.0.33
 CATEGORIES=	biology devel
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	C++ SED-ML library
 WWW=		https://github.com/fbergmann/libSEDML
 
 LICENSE=	BSD2CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 BUILD_DEPENDS=	libsbml>0:biology/libsbml \
 		libnuml>0:biology/libnuml # statically linked, even into a shared library, see https://github.com/fbergmann/libSEDML/issues/155
 RUN_DEPENDS=	libsbml>0:biology/libsbml \
 		libnuml>0:biology/libnuml # when static lib libnuml.a is fixed these should be run-time dependency
 
-USES=		cmake compiler:c++11-lang gnome
+USES=		cmake:testing compiler:c++11-lang gnome
 USE_GNOME=	libxml2
 USE_LDCONFIG=	yes
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	fbergmann
 GH_PROJECT=	libSEDML
 
+CMAKE_OFF=		BUILD_TESTS
+CMAKE_TESTING_ON=	BUILD_TESTS
+
 post-install:
 	# no need to install LICENSE, README, VERSION
 	@${RM} -r ${STAGEDIR}${DATADIR}
 	# workaround for https://github.com/fbergmann/libSEDML/issues/163
 	${RM} -r ${STAGEDIR}${PREFIX}/share/cmake
 
 # the project builds static libs with -fPIC, see https://github.com/fbergmann/libSEDML/issues/155
 
+# tests as of 2.0.33: All tests passed (351 assertions in 33 test cases)
+
 .include <bsd.port.mk>
diff --git a/biology/libsedml/distinfo b/biology/libsedml/distinfo
index 7f650a78b96f..2740d95dfdbb 100644
--- a/biology/libsedml/distinfo
+++ b/biology/libsedml/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1654751397
-SHA256 (fbergmann-libSEDML-v2.0.32_GH0.tar.gz) = 95f0781c19e73bb86618cce1678f4238f3cc11abe070b49f2a25e869071b8069
-SIZE (fbergmann-libSEDML-v2.0.32_GH0.tar.gz) = 966584
+TIMESTAMP = 1745471328
+SHA256 (fbergmann-libSEDML-v2.0.33_GH0.tar.gz) = a3f69ecb5dc1084343d4de5dc0990bdd9def2f7eb819986015d33ca9735dbe76
+SIZE (fbergmann-libSEDML-v2.0.33_GH0.tar.gz) = 1006915
diff --git a/biology/libsedml/pkg-plist b/biology/libsedml/pkg-plist
index eca7bc710ba9..ab1d1ee629f9 100644
--- a/biology/libsedml/pkg-plist
+++ b/biology/libsedml/pkg-plist
@@ -1,119 +1,119 @@
 include/sedml/SedAbstractCurve.h
 include/sedml/SedAbstractTask.h
 include/sedml/SedAddXML.h
 include/sedml/SedAdjustableParameter.h
 include/sedml/SedAlgorithm.h
 include/sedml/SedAlgorithmParameter.h
 include/sedml/SedAnalysis.h
 include/sedml/SedAppliedDimension.h
 include/sedml/SedAxis.h
 include/sedml/SedBase.h
 include/sedml/SedBounds.h
 include/sedml/SedChange.h
 include/sedml/SedChangeAttribute.h
 include/sedml/SedChangeXML.h
 include/sedml/SedComputeChange.h
 include/sedml/SedConstructorException.h
 include/sedml/SedCurve.h
 include/sedml/SedDataDescription.h
 include/sedml/SedDataGenerator.h
 include/sedml/SedDataRange.h
 include/sedml/SedDataSet.h
 include/sedml/SedDataSource.h
 include/sedml/SedDocument.h
 include/sedml/SedElementFilter.h
 include/sedml/SedError.h
 include/sedml/SedErrorLog.h
 include/sedml/SedErrorTable.h
 include/sedml/SedExperimentReference.h
 include/sedml/SedFigure.h
 include/sedml/SedFill.h
 include/sedml/SedFitExperiment.h
 include/sedml/SedFitMapping.h
 include/sedml/SedFunctionalRange.h
 include/sedml/SedLeastSquareObjectiveFunction.h
 include/sedml/SedLine.h
 include/sedml/SedListOf.h
 include/sedml/SedListOfAdjustableParameters.h
 include/sedml/SedListOfAlgorithmParameters.h
 include/sedml/SedListOfAppliedDimensions.h
 include/sedml/SedListOfChanges.h
 include/sedml/SedListOfCurves.h
 include/sedml/SedListOfDataDescriptions.h
 include/sedml/SedListOfDataGenerators.h
 include/sedml/SedListOfDataSets.h
 include/sedml/SedListOfDataSources.h
 include/sedml/SedListOfExperimentReferences.h
 include/sedml/SedListOfFitExperiments.h
 include/sedml/SedListOfFitMappings.h
 include/sedml/SedListOfModels.h
 include/sedml/SedListOfOutputs.h
 include/sedml/SedListOfParameters.h
 include/sedml/SedListOfRanges.h
 include/sedml/SedListOfSetValues.h
 include/sedml/SedListOfSimulations.h
 include/sedml/SedListOfSlices.h
 include/sedml/SedListOfStyles.h
 include/sedml/SedListOfSubPlots.h
 include/sedml/SedListOfSubTasks.h
 include/sedml/SedListOfSurfaces.h
 include/sedml/SedListOfTasks.h
 include/sedml/SedListOfVariables.h
 include/sedml/SedMarker.h
 include/sedml/SedModel.h
 include/sedml/SedNamespaces.h
 include/sedml/SedObjective.h
 include/sedml/SedOneStep.h
 include/sedml/SedOutput.h
 include/sedml/SedParameter.h
 include/sedml/SedParameterEstimationReport.h
 include/sedml/SedParameterEstimationResultPlot.h
 include/sedml/SedParameterEstimationTask.h
 include/sedml/SedPlot.h
 include/sedml/SedPlot2D.h
 include/sedml/SedPlot3D.h
 include/sedml/SedRange.h
 include/sedml/SedReader.h
 include/sedml/SedRemoveXML.h
 include/sedml/SedRepeatedTask.h
 include/sedml/SedReport.h
 include/sedml/SedSetValue.h
 include/sedml/SedShadedArea.h
 include/sedml/SedSimulation.h
 include/sedml/SedSlice.h
 include/sedml/SedSteadyState.h
 include/sedml/SedStyle.h
 include/sedml/SedSubPlot.h
 include/sedml/SedSubTask.h
 include/sedml/SedSurface.h
 include/sedml/SedTask.h
 include/sedml/SedTypeCodes.h
 include/sedml/SedTypes.h
 include/sedml/SedUniformRange.h
 include/sedml/SedUniformTimeCourse.h
 include/sedml/SedVariable.h
 include/sedml/SedVectorRange.h
 include/sedml/SedVisitor.h
 include/sedml/SedWaterfallPlot.h
 include/sedml/SedWriter.h
 include/sedml/common/SedOperationReturnValues.h
 include/sedml/common/SedmlEnumerations.h
 include/sedml/common/common.h
 include/sedml/common/extern.h
 include/sedml/common/libsedml-config-common.h
 include/sedml/common/libsedml-config.h
 include/sedml/common/libsedml-namespace.h
 include/sedml/common/libsedml-version.h
 include/sedml/common/sedmlfwd.h
 lib/cmake/sedml-config-version.cmake
 lib/cmake/sedml-config.cmake
 lib/cmake/sedml-static-config-version.cmake
 lib/cmake/sedml-static-config.cmake
 lib/cmake/sedml-static-targets-%%CMAKE_BUILD_TYPE%%.cmake
 lib/cmake/sedml-static-targets.cmake
 lib/cmake/sedml-targets-%%CMAKE_BUILD_TYPE%%.cmake
 lib/cmake/sedml-targets.cmake
 lib/libsedml-static.a
 lib/libsedml.so
 lib/libsedml.so.2
-lib/libsedml.so.2.0.32
+lib/libsedml.so.2.0.33
diff --git a/biology/py-libsedml/Makefile b/biology/py-libsedml/Makefile
index 6b8e59cf0a3e..8e56763ea40b 100644
--- a/biology/py-libsedml/Makefile
+++ b/biology/py-libsedml/Makefile
@@ -1,35 +1,35 @@
 PORTNAME=	libsedml
 DISTVERSIONPREFIX=	v
-DISTVERSION=	2.0.32
+DISTVERSION=	2.0.33
 CATEGORIES=	biology devel
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	SED-ML library for Python
 WWW=		https://github.com/fbergmann/libSEDML
 
 LICENSE=	BSD2CLAUSE
 LICENSE_FILE=	${WRKSRC}/../../../LICENSE.txt
 
 BUILD_DEPENDS=	swig:devel/swig
 LIB_DEPENDS=	libsedml.so:biology/libsedml \
 		libsbml.so:biology/libsbml \
 		libnuml.so:biology/libnuml
 
 USES=		cmake localbase:ldflags python
 USE_PYTHON=	flavors
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	fbergmann
 GH_PROJECT=	libSEDML
 
 CMAKE_ARGS=	-DCMAKE_INSTALL_LIBDIR=lib
 
 LDFLAGS+=	-lsedml -lsbml -lnuml # otherwise it builds a broken shared object, see https://github.com/NuML/NuML/issues/21
 
 WRKSRC_SUBDIR=	src/bindings/python
 
 do-test: install
 	@${PYTHON_CMD} ${FILESDIR}/quick-test.py
 
 .include <bsd.port.mk>
diff --git a/biology/py-libsedml/distinfo b/biology/py-libsedml/distinfo
index 7bc4e026e156..529392d3d0ac 100644
--- a/biology/py-libsedml/distinfo
+++ b/biology/py-libsedml/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1654751643
-SHA256 (fbergmann-libSEDML-v2.0.32_GH0.tar.gz) = 95f0781c19e73bb86618cce1678f4238f3cc11abe070b49f2a25e869071b8069
-SIZE (fbergmann-libSEDML-v2.0.32_GH0.tar.gz) = 966584
+TIMESTAMP = 1745471845
+SHA256 (fbergmann-libSEDML-v2.0.33_GH0.tar.gz) = a3f69ecb5dc1084343d4de5dc0990bdd9def2f7eb819986015d33ca9735dbe76
+SIZE (fbergmann-libSEDML-v2.0.33_GH0.tar.gz) = 1006915
diff --git a/biology/py-libsedml/files/patch-CMakeLists.txt b/biology/py-libsedml/files/patch-CMakeLists.txt
index 1ad8d3a30828..576ed26d7b4c 100644
--- a/biology/py-libsedml/files/patch-CMakeLists.txt
+++ b/biology/py-libsedml/files/patch-CMakeLists.txt
@@ -1,33 +1,22 @@
---- CMakeLists.txt.orig	2022-06-07 11:34:09 UTC
+--- CMakeLists.txt.orig	2025-04-24 05:19:57 UTC
 +++ CMakeLists.txt
-@@ -37,8 +37,8 @@ endif(LIBSEDML_REMOVE_WRAPPERS)
- 
- 
- set(SWIG_EXTRA_FLAGS -DSWIGEXPORT 
--   -DLIBSBML_CPP_NAMESPACE_BEGIN -DLIBSBML_CPP_NAMESPACE_END -DLIBSBML_CPP_NAMESPACE_QUALIFIER -DLIBSBML_CPP_NAMESPACE_USE
--   -DLIBNUML_CPP_NAMESPACE_BEGIN -DLIBNUML_CPP_NAMESPACE_END -DLIBNUML_CPP_NAMESPACE_QUALIFIER -DLIBNUML_CPP_NAMESPACE_USE
-+   -DLIBSBML_CPP_NAMESPACE_BEGIN= -DLIBSBML_CPP_NAMESPACE_END= -DLIBSBML_CPP_NAMESPACE_QUALIFIER= -DLIBSBML_CPP_NAMESPACE_USE=
-+   -DLIBNUML_CPP_NAMESPACE_BEGIN= -DLIBNUML_CPP_NAMESPACE_END= -DLIBNUML_CPP_NAMESPACE_QUALIFIER= -DLIBNUML_CPP_NAMESPACE_USE=
-    )
- if(NOT UNIX)
-   set(SWIG_EXTRA_FLAGS ${SWIG_EXTRA_FLAGS} -DSWIGWIN -DSWIG_CSHARP_NO_WSTRING_HELPER )
 @@ -49,6 +49,7 @@ ADD_CUSTOM_COMMAND(  
      OUTPUT ${CMAKE_CURRENT_BINARY_DIR}/libsedml_wrap.cpp
      COMMAND "${SWIG_EXECUTABLE}"
      ARGS  -I${CMAKE_CURRENT_SOURCE_DIR}/../swig/
 +      -I${CMAKE_INSTALL_PREFIX}/include
        -I${CMAKE_CURRENT_SOURCE_DIR}/../../
        -I${CMAKE_CURRENT_BINARY_DIR}/../../
        -I${CMAKE_CURRENT_SOURCE_DIR}/../../sedml
 @@ -125,9 +126,9 @@ if (PYTHON_USE_DYNAMIC_LOOKUP)
    if (APPLE)
      set_target_properties (binding_python_lib PROPERTIES LINK_FLAGS "-undefined dynamic_lookup")
    endif()
 -  target_link_libraries(binding_python_lib ${LIBSEDML_LIBRARY}-static)
 +  target_link_libraries(binding_python_lib ${LIBSEDML_LIBRARY})
  else()
 -  target_link_libraries(binding_python_lib ${LIBSEDML_LIBRARY}-static ${PYTHON_LIBRARIES})
 +  target_link_libraries(binding_python_lib ${LIBSEDML_LIBRARY} ${PYTHON_LIBRARIES})
  endif()
  
  #