diff --git a/biology/py-PySCeS/Makefile b/biology/py-PySCeS/Makefile
index b6824a2d904c..7212074a9b2e 100644
--- a/biology/py-PySCeS/Makefile
+++ b/biology/py-PySCeS/Makefile
@@ -1,41 +1,41 @@
 PORTNAME=	pysces
-DISTVERSION=	1.2.2
-PORTREVISION=	3
+DISTVERSION=	1.2.3
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
-DISTNAME=	${PORTNAME:tl}-${DISTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python Simulator for Cellular Systems
 WWW=		https://pysces.github.io/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}meson-python>0:devel/meson-python@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}numpy>=1.16:math/py-numpy@${PY_FLAVOR}
-PY_EXTRA=	${PYTHON_PKGNAMEPREFIX}python-libsbml>0:biology/py-python-libsbml@${PY_FLAVOR}
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=1.16:math/py-numpy@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}numpy>=2.0.0,1:math/py-numpy@${PY_FLAVOR}
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=1.23.5,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}matplotlib>0:math/py-matplotlib@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>0:science/py-scipy@${PY_FLAVOR} \
-		${PY_EXTRA}
+		${PYTHON_PKGNAMEPREFIX}numdifftools>0:math/py-numdifftools@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}python-libsbml>0:biology/py-python-libsbml@${PY_FLAVOR}
 
 USES=		fortran localbase:ldflags python
 USE_PYTHON=	pep517 autoplist pytest
 
 LDFLAGS+=	-lpython${PYTHON_VER}
 
 BINARY_ALIAS=	python3=${PYTHON_CMD}
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/pysces/pitcon/pitcon.cpython-${PYTHON_SUFFIX}.so \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/pysces/nleq2/nleq2.cpython-${PYTHON_SUFFIX}.so
 
 do-test: # from section 2.1 Loading PySCeS in http://pysces.sourceforge.net/pdf/userguide.pdf
 	@${SETENV} ${TEST_ENV} ${PYTHON_CMD} -c "import pysces; pysces.test();"
 
+# tests as of 1.2.3: 30 tests passed
+
 .include <bsd.port.mk>
diff --git a/biology/py-PySCeS/distinfo b/biology/py-PySCeS/distinfo
index 88232acfde21..2a5e72be7cad 100644
--- a/biology/py-PySCeS/distinfo
+++ b/biology/py-PySCeS/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1722664974
-SHA256 (pysces-1.2.2.tar.gz) = 8d71e330594d63281ed88de9925776497f57c0952092d2a87df0c031cb6c8101
-SIZE (pysces-1.2.2.tar.gz) = 2754765
+TIMESTAMP = 1781153152
+SHA256 (pysces-1.2.3.tar.gz) = 437487624c3127f0bc5adc28b639a3ee4cbe614f2554857b3ab4c1f3813ffe42
+SIZE (pysces-1.2.3.tar.gz) = 2775077