diff --git a/biology/mothur/Makefile b/biology/mothur/Makefile
index 20ffc948ef5b..f26f63bd48fe 100644
--- a/biology/mothur/Makefile
+++ b/biology/mothur/Makefile
@@ -1,28 +1,28 @@
 PORTNAME=	mothur
 DISTVERSIONPREFIX=	v
-DISTVERSION=	1.46.0
+DISTVERSION=	1.46.1
 CATEGORIES=	biology
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Software for bioinformatics of the microbial ecology community
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE.md
 
 BUILD_DEPENDS=	bash:shells/bash
 
 USES=		compiler:c++11-lang gmake localbase readline
 USE_GITHUB=	yes
 
 MAKE_ARGS=	INSTALL_DIR=${STAGEDIR}${PREFIX}/bin
 
 ALL_TARGET=	${PORTNAME}
 
 BINARY_ALIAS=	g++=${CXX}
 
 PLIST_FILES=	bin/${PORTNAME}
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PREFIX}/bin/${PORTNAME}
 
 .include <bsd.port.mk>
diff --git a/biology/mothur/distinfo b/biology/mothur/distinfo
index 45c1d1a93280..66ac666fa9a1 100644
--- a/biology/mothur/distinfo
+++ b/biology/mothur/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1629994194
-SHA256 (mothur-mothur-v1.46.0_GH0.tar.gz) = 0bb833b82c8841dca8cecfa58c93d537ec55f4a66d0def40916668a18baf6424
-SIZE (mothur-mothur-v1.46.0_GH0.tar.gz) = 1637691
+TIMESTAMP = 1630572964
+SHA256 (mothur-mothur-v1.46.1_GH0.tar.gz) = 29b500b3c92d726cde34922f697f2e47f0b7127d76d9a6fb167cc2b8ba3d00fd
+SIZE (mothur-mothur-v1.46.1_GH0.tar.gz) = 1637738