diff --git a/misc/snakemake/Makefile b/misc/snakemake/Makefile
index 60eeeba3ac5e..ca82d5373558 100644
--- a/misc/snakemake/Makefile
+++ b/misc/snakemake/Makefile
@@ -1,36 +1,36 @@
 PORTNAME=	snakemake
-DISTVERSION=	6.5.2
+DISTVERSION=	6.6.1
 CATEGORIES=	misc python
 MASTER_SITES=	CHEESESHOP
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Workflow management system
 
 LICENSE=	MIT
 
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}appdirs>0:devel/py-appdirs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}connection_pool>=0.0.3>0:devel/py-connection_pool@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}configargparse>0:devel/py-configargparse@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}datrie>0:devel/py-datrie@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}docutils>0:textproc/py-docutils@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}filelock>0:sysutils/py-filelock@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}gitpython>0:devel/py-gitpython@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}jsonschema>0:devel/py-jsonschema@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}nbformat>0:devel/py-nbformat@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}PuLP>=2.0:math/py-PuLP@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}psutil>0:sysutils/py-psutil@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}ratelimiter>0:devel/py-ratelimiter@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>0:www/py-requests@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}smart-open>0:net/py-smart-open@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}smart-open>=3.0:net/py-smart-open@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}stopit>0:devel/py-stopit@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tabulate>0:devel/py-tabulate@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}toposort>0:devel/py-toposort@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wrapt>0:devel/py-wrapt@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}yaml>0:devel/py-yaml@${PY_FLAVOR}
 
 USES=		python:3.5+
 USE_PYTHON=	distutils noflavors autoplist
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/misc/snakemake/distinfo b/misc/snakemake/distinfo
index 7de9fc8eca07..36221e5618a1 100644
--- a/misc/snakemake/distinfo
+++ b/misc/snakemake/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1625419109
-SHA256 (snakemake-6.5.2.tar.gz) = deee1888c02404f5cd5c78ff360867972831124a1fb3f5af8db1f3f39fbfd7fd
-SIZE (snakemake-6.5.2.tar.gz) = 270023
+TIMESTAMP = 1628045488
+SHA256 (snakemake-6.6.1.tar.gz) = 91637a801342f3bc349c033b284fef7c0201b4e5e29d5650cb6c7f69096d4184
+SIZE (snakemake-6.6.1.tar.gz) = 270410