diff --git a/astro/gpsd/Makefile b/astro/gpsd/Makefile
index c027fb09ac9b..60129a7ba9c2 100644
--- a/astro/gpsd/Makefile
+++ b/astro/gpsd/Makefile
@@ -1,172 +1,174 @@
 PORTNAME=	gpsd
 PORTVERSION=	3.25
 PORTREVISION=	3
 CATEGORIES=	astro geography
 MASTER_SITES=	SAVANNAH
 
 MAINTAINER=	z7dr6ut7gs@snkmail.com
 COMMENT=	Daemon that monitors one or more GPSes attached to a host computer
 WWW=		https://gpsd.gitlab.io/gpsd/index.html
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/COPYING
 
 FLAVORS=	default nox11
 FLAVOR?=	${FLAVORS:[1]}
 nox11_PKGNAMESUFFIX=	-nox11
 
+BUILD_DEPENDS=	${PY_SETUPTOOLS}
+
 USES=		cpe pathfix pkgconfig python scons
 CPE_VENDOR=	gpsd_project
 USE_LDCONFIG=	yes
 USE_RC_SUBR=	gpsd
 
 PIE_UNSAFE=	yes
 
 MAKE_ARGS=	manbuild=no \
 		mandir="share/man" \
 		pkgconfig="libdata/pkgconfig" \
 		prefix="${PREFIX}" \
 		qt=no \
 		target_python="${PYTHON_CMD}"
 MAKE_ENV=	DESTDIR="${STAGEDIR}"
 PLIST_SUB=	PYTHON_EGGINFO=gps-${PORTVERSION}.egg-info
 
 OPTIONS_DEFINE=		AIVDM ASHTECH CPPBIND DBUS EARTHMATE EVERMORE FURY FV18 \
 			GARMIN GARMINTXT GEOSTAR GPSCLOCK IPV6 ITRAX MTK NAVCOM \
 			NCURSES NETFEED NMEA0183 NTP NTPSHM NTRIP OCEANSERVER \
 			ONCORE PASSTHROUGH PPS PROFILING PYSERIAL RECONFIGURE \
 			RTCM104V2 RTCM104V3 SHMEXPORT SIRF SOCKEXPORT \
 			SUPERSTARII TIMING TNT TRIPMATE TSIP UBLOX USB X11
 
 .if ${FLAVOR} == nox11
 COMMENT+=	(without GUI)
 OPTIONS_EXCLUDE=	X11
 .endif
 
 OPTIONS_DEFAULT=	AIVDM ASHTECH CPPBIND EARTHMATE EVERMORE FURY FV18 \
 			GARMIN GARMINTXT GEOSTAR GPSCLOCK ITRAX NAVCOM NCURSES \
 			NETFEED NMEA0183 NTP NTPSHM NTRIP OCEANSERVER ONCORE \
 			PASSTHROUGH PYSERIAL RECONFIGURE RTCM104V2 RTCM104V3 \
 			SHMEXPORT SIRF SOCKEXPORT SUPERSTARII TIMING TNT \
 			TRIPMATE TSIP UBLOX USB X11
 OPTIONS_SUB=		yes
 
 AIVDM_DESC=		Aivdm support
 ASHTECH_DESC=		Ashtech support
 CPPBIND_DESC=		Build C++ bindings
 EARTHMATE_DESC=		DeLorme EarthMate Zodiac support
 EVERMORE_DESC=		Evermore binary support
 FURY_DESC=		Jackson Labs Fury and Firefly support
 FV18_DESC=		San Jose Navigation FV-18 support
 GARMIN_DESC=		Garmin kernel driver support
 GARMINTXT_DESC=		Garmin Simple Text support
 GEOSTAR_DESC=		Geostar Protocol support
 GPSCLOCK_DESC=		GPSclock support
 ITRAX_DESC=		iTrax support
 MTK_DESC=		MTK-3301 support
 NAVCOM_DESC=		Navcom support
 NCURSES_DESC=		Build with ncurses
 NETFEED_DESC=		Build support for handling TCP/IP data sources
 NMEA0183_DESC=		NMEA0183 support
 NTP_DESC=		NTP time hinting support
 NTPSHM_DESC=		NTP time hinting support via shared memory
 NTRIP_DESC=		NTRIP support
 OCEANSERVER_DESC=	Oceanserver support
 ONCORE_DESC=		Motorola OnCore chipset support
 PASSTHROUGH_DESC=	Build support for passing through JSON
 PPS_DESC=		PPS time syncing support
 PROFILING_DESC=		Profiling support
 PYSERIAL_DESC=		Python serial port support
 RECONFIGURE_DESC=	Allow gpsd to change device settings
 RTCM104V2_DESC=		rtcm104v2 support
 RTCM104V3_DESC=		rtcm104v3 support
 SHMEXPORT_DESC=		Enable export via shared memory
 SIRF_DESC=		SiRF chipset support
 SOCKEXPORT_DESC=	Enable export over sockets
 SUPERSTARII_DESC=	SuperStarII support
 TIMING_DESC=		Build latency timing support
 TNT_DESC=		True North Technologies support
 TRIPMATE_DESC=		DeLorme TripMate support
 TSIP_DESC=		Trimble TSIP support
 UBLOX_DESC=		u-blox protocol support
 USB_DESC=		libusb support for USB devices
 
 # Options related to GPS protocols
 NMEA0183_MAKE_ARGS_OFF=		nmea0183=no
 ASHTECH_MAKE_ARGS_OFF=		ashtech=no
 EARTHMATE_MAKE_ARGS_OFF=	earthmate=no
 EVERMORE_MAKE_ARGS_OFF=		evermore=no
 FURY_MAKE_ARGS_OFF=		fury=no
 FV18_MAKE_ARGS_OFF=		fv18=no
 GARMIN_MAKE_ARGS_OFF=		garmin=no
 GARMINTXT_MAKE_ARGS_OFF=	garmintxt=no
 GEOSTAR_MAKE_ARGS_OFF=		geostar=no
 ITRAX_MAKE_ARGS_OFF=		itrax=no
 MTK_MAKE_ARGS_OFF=		mtk3301=no
 NAVCOM_MAKE_ARGS_OFF=		navcom=no
 ONCORE_MAKE_ARGS_OFF=		oncore=no
 SIRF_MAKE_ARGS_OFF=		sirf=no
 SUPERSTARII_MAKE_ARGS_OFF=	superstar2=no
 TNT_MAKE_ARGS_OFF=		tnt=no
 TRIPMATE_MAKE_ARGS_OFF=		tripmate=no
 TSIP_MAKE_ARGS_OFF=		tsip=no
 UBLOX_MAKE_ARGS_OFF=		ublox=no
 
 # Options related to Non-GPS protocols
 AIVDM_MAKE_ARGS_OFF=		aivdm=no
 GPSCLOCK_MAKE_ARGS_OFF=		gpsclock=no
 NTRIP_MAKE_ARGS_OFF=		ntrip=no
 OCEANSERVER_MAKE_ARGS_OFF=	oceanserver=no
 RTCM104V2_MAKE_ARGS_OFF=	rtcm104v2=no
 RTCM104V3_MAKE_ARGS_OFF=	rtcm104v3=no
 
 # Time service
 NTP_MAKE_ARGS_OFF=	ntp=no
 NTPSHM_MAKE_ARGS_OFF=	ntpshm=no
 PPS_MAKE_ARGS_OFF=	pps=no
 PPS_IMPLIES=		NTPSHM
 
 # Export methods
 SOCKEXPORT_MAKE_ARGS_OFF=	socket_export=no
 DBUS_LIB_DEPENDS=		libdbus-1.so:devel/dbus
 DBUS_MAKE_ARGS=			dbus_export=yes
 DBUS_MAKE_ARGS_OFF=		dbus_export=no
 SHMEXPORT_MAKE_ARGS_OFF=	shm_export=no
 
 # Communication
 USB_MAKE_ARGS_OFF=		usb=no
 IPV6_MAKE_ARGS_OFF=		ipv6=no
 NETFEED_MAKE_ARGS_OFF=		netfeed=no
 PASSTHROUGH_MAKE_ARGS_OFF=	passthrough=no
 
 # Other daemon options
 TIMING_MAKE_ARGS_OFF=	timing=no
 
 # Client-side options
 NCURSES_MAKE_ARGS_OFF=		ncurses=no
 NCURSES_USES=			ncurses
 RECONFIGURE_MAKE_ARGS_OFF=	reconfigure=no
 CPPBIND_MAKE_ARGS_OFF=		libgpsmm=no
 PYSERIAL_BUILD_DEPENDS=		${PYTHON_PKGNAMEPREFIX}pyserial>=0:comms/py-pyserial@${PY_FLAVOR}
 PYSERIAL_RUN_DEPENDS=		${PYTHON_PKGNAMEPREFIX}pyserial>=0:comms/py-pyserial@${PY_FLAVOR}
 X11_BUILD_DEPENDS=		${PYTHON_PKGNAMEPREFIX}pycairo>=0:graphics/py-pycairo@${PY_FLAVOR}
 X11_RUN_DEPENDS=		${PYTHON_PKGNAMEPREFIX}pycairo>=0:graphics/py-pycairo@${PY_FLAVOR}
 X11_USES=			gnome
 X11_USE=			gnome=gtk30 pygobject3
 X11_MAKE_ARGS_OFF=		xgps=no
 
 # Build control
 PROFILING_MAKE_ARGS=	profiling=yes
 
 # generates .py[co] files for installed modules
 # if that's not done, ${PYTHON_SITELIBDIR}/gps will be polluted
 # with these files when module is imported from root user
 post-install:
 	(cd ${STAGEDIR}${PREFIX} && \
 	${PYTHON_CMD} ${PYTHON_LIBDIR}/compileall.py \
 		-d ${PYTHONPREFIX_SITELIBDIR} -f ${PYTHONPREFIX_SITELIBDIR:S;${PREFIX}/;;} && \
 	${PYTHON_CMD} -O ${PYTHON_LIBDIR}/compileall.py \
 		-d ${PYTHONPREFIX_SITELIBDIR} -f ${PYTHONPREFIX_SITELIBDIR:S;${PREFIX}/;;})
 	${RM} -r ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/gps/__pycache__
 
 .include <bsd.port.mk>
diff --git a/audio/py-essentia/Makefile b/audio/py-essentia/Makefile
index 272d1dffafbd..c4c82bb84b01 100644
--- a/audio/py-essentia/Makefile
+++ b/audio/py-essentia/Makefile
@@ -1,48 +1,49 @@
 PORTNAME=	essentia
 DISTVERSIONPREFIX=	v
 DISTVERSION=	2.1_beta5-859
 DISTVERSIONSUFFIX=	-gb247091f
 PORTREVISION=	5
 CATEGORIES=	audio
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python bindings for essentia, C++ library for audio and music analysis
 WWW=		https://essentia.upf.edu/
 
 LICENSE=	AGPLv3
 LICENSE_FILE=	${WRKSRC}/COPYING.txt
 
 BUILD_DEPENDS=	${PYNUMPY} \
+		${PY_SETUPTOOLS} \
 		${PYTHON_PKGNAMEPREFIX}six>0:devel/py-six@${PY_FLAVOR}
 LIB_DEPENDS=	libessentia.so:audio/essentia
 RUN_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}six>0:devel/py-six@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pyyaml>=0:devel/py-pyyaml@${PY_FLAVOR}
 
 MASTER_SITES=	https://raw.githubusercontent.com/MTG/essentia/d02b6c752046802a711530e2bcd5feafca42247d/
 DISTFILES=	waf
 EXTRACT_ONLY=	${GH_ACCOUNT}-${PORTNAME}*.gz
 
 USES=		eigen:3 pkgconfig python
 USE_PYTHON=	pytest
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	MTG
 
 post-extract:
 	@${CP} ${DISTDIR}/waf ${WRKSRC}/
 
 do-configure:
 	@cd ${BUILD_WRKSRC} && ${SETENV} ${BUILD_ENV} ${PYTHON_CMD} waf configure --only-python
 
 do-build:
 	@cd ${BUILD_WRKSRC} && ${SETENV} ${BUILD_ENV} ${PYTHON_CMD} waf build --only-python
 
 do-install:
 	# install
 	cd ${BUILD_WRKSRC} && ${SETENV} ${BUILD_ENV} ${PYTHON_CMD} waf install --only-python --prefix ${PREFIX} --destdir ${STAGEDIR}
 	# strip
 	${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/essentia/_essentia${PYTHON_TAG}.so
 
 .include <bsd.port.mk>
diff --git a/biology/libneurosim/Makefile b/biology/libneurosim/Makefile
index 0fd9116f8552..7df8f8d05a61 100644
--- a/biology/libneurosim/Makefile
+++ b/biology/libneurosim/Makefile
@@ -1,33 +1,34 @@
 PORTNAME=	libneurosim
 DISTVERSIONPREFIX=	v
 DISTVERSION=	1.2.0
 PORTREVISION=	1
 CATEGORIES=	biology
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Common interfaces for neuronal simulators
 WWW=		https://github.com/INCF/libneurosim
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/COPYING
 
 LIB_DEPENDS=	libltdl.so:devel/libltdl
 
 USES=		autoreconf libtool localbase
 USE_LDCONFIG=	yes
 
 GNU_CONFIGURE=	yes
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	INCF
 
 INSTALL_TARGET=	install-strip
 
 OPTIONS_DEFINE=		PYTHON
 OPTIONS_DEFAULT=	PYTHON
 OPTIONS_SUB=		yes
 
+PYTHON_BUILD_DEPENDS=	${PY_SETUPTOOLS}
 PYTHON_CONFIGURE_ON=	--with-python=${PYTHON_VER:R}
 PYTHON_USES=	python
 
 .include <bsd.port.mk>
diff --git a/devel/libarea/Makefile b/devel/libarea/Makefile
index 47ea28798343..20e931313d41 100644
--- a/devel/libarea/Makefile
+++ b/devel/libarea/Makefile
@@ -1,29 +1,30 @@
 PORTNAME=	libarea
 PORTVERSION=	20191031
 PORTREVISION=	1
 CATEGORIES=	devel cad
 
 MAINTAINER=	ports@FreeBSD.org
 COMMENT=	CAM-related software for profile and pocketing operations
 WWW=		https://github.com/heeks/libarea
 
 LICENSE=	BSD3CLAUSE
 
 LIB_DEPENDS=	${PY_BOOST}
+BUILD_DEPENDS=	${PY_SETUPTOOLS}
 
 USES=		cmake python
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	Heeks
 GH_TAGNAME=	2752cd9
 
 USE_LDCONFIG=	yes
 
 CXXFLAGS+=	"-DBOOST_TIMER_ENABLE_DEPRECATED=yes"
 
 post-patch:
 	@${REINPLACE_CMD} 's,COMMAND python ,COMMAND ${PYTHON_CMD} , ; \
 		s,COMMAND python-config ,COMMAND ${PYTHON_CMD}-config ,' \
 		${WRKSRC}/CMakeLists.txt
 
 .include <bsd.port.mk>
diff --git a/devel/py-ice/Makefile b/devel/py-ice/Makefile
index eabadaa8d507..79494ad777db 100644
--- a/devel/py-ice/Makefile
+++ b/devel/py-ice/Makefile
@@ -1,39 +1,40 @@
 CATEGORIES=	devel python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	grembo@FreeBSD.org
 COMMENT=	Ice (Internet Communications Engine) language mapping for Python
 
 LICENSE=	GPLv2
 
-BUILD_DEPENDS=	mcpp:devel/mcpp
+BUILD_DEPENDS=	mcpp:devel/mcpp \
+		${PY_SETUPTOOLS}
 LIB_DEPENDS=	libIce.so.${LIB_VRS}:devel/ice
 
 USES=		compiler:c++11-lang python shebangfix
 USE_CXXSTD=	c++14
 USE_PYTHON=	py3kplist
 SLAVE_PORT=	yes
 MASTERDIR=	${.CURDIR}/../ice
 PLIST=		${.CURDIR}/pkg-plist
 
 BUILD_WRKSRC=	${WRKSRC}/python
 INSTALL_WRKSRC=	${WRKSRC}/python
 
 SHEBANG_FILES=	${BUILD_WRKSRC}/config/s2py.py
 
 MAKE_ENV+=	PYTHON_VERSION=${PYTHON_VERSION}
 
 LIB_VRS=	${PORTVERSION:S|.||g:C|[0-9]$||}
 PLIST_SUB=	LIB_VERSION="${PORTVERSION}" LIB_VRS="${LIB_VRS}"
 
 OPTIONS_DEFINE=	DEBUG TEST
 
 post-install:
 	${STRIP_CMD} ${STAGEDIR}${PYSITEDIR}/Ice/*.so.*
 	${ECHO} "Ice" > ${STAGEDIR}${PYSITEDIR}/Ice.pth
 	@${FIND} ${STAGEDIR}${PYSITEDIR}/Ice \( -name "*.pyc" -or -name "*.pyo" \) \
 		-exec ${CHMOD} u+w {} \;
 	@${PYTHON_CMD} -m compileall -d ${PYSITEDIR}/Ice ${STAGEDIR}${PYSITEDIR}/Ice
 	@${PYTHON_CMD} -O -m compileall -d ${PYSITEDIR}/Ice ${STAGEDIR}${PYSITEDIR}/Ice
 
 .include "${MASTERDIR}/Makefile"
diff --git a/math/gau2grid/Makefile b/math/gau2grid/Makefile
index acdee4aac187..830f77cad108 100644
--- a/math/gau2grid/Makefile
+++ b/math/gau2grid/Makefile
@@ -1,26 +1,27 @@
 PORTNAME=	gau2grid
 DISTVERSIONPREFIX=	v
 DISTVERSION=	2.0.7
 PORTREVISION=	1
 CATEGORIES=	math python
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Fast computation of a gaussian and its derivative on a grid
 WWW=		https://github.com/dgasmith/gau2grid
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 ONLY_FOR_ARCHS=	amd64 i386 powerpc64 powerpc64le
 ONLY_FOR_ARCHS_REASON=	BUG: ValueError: descr is not a valid dtype descriptor: '<f16' (see https://github.com/dgasmith/gau2grid/issues/25)
 
-BUILD_DEPENDS=	${PYNUMPY}
+BUILD_DEPENDS=	${PYNUMPY} \
+		${PY_SETUPTOOLS}
 
 USES=		cmake compiler:c11 python:build # C code build depends on python to generate some headers
 USE_GITHUB=	yes
 GH_ACCOUNT=	dgasmith
 USE_LDCONFIG=	yes
 
 CMAKE_OFF=	ENABLE_XHOST
 
 .include <bsd.port.mk>
diff --git a/math/py-pyaudi/Makefile b/math/py-pyaudi/Makefile
index f3c2cc619eb0..d80f9c712ce1 100644
--- a/math/py-pyaudi/Makefile
+++ b/math/py-pyaudi/Makefile
@@ -1,49 +1,50 @@
 PORTNAME=	pyaudi
 DISTVERSIONPREFIX=	v
 DISTVERSION=	1.9.2-1
 DISTVERSIONSUFFIX=	-g899eb78
 PORTREVISION=	19
 CATEGORIES=	math
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Library implementing the algebra of Taylor polynomials
 WWW=		http://darioizzo.github.io/audi/ \
 		https://github.com/darioizzo/audi
 
 LICENSE=	GPLv2
 LICENSE_FILE=	${WRKSRC}/../LICENSE
 
 BROKEN_armv7=	compilation fails: constraints not satisfied for class template 'd_packed_monomial' [with T = unsigned long long, PSize = 8]
 BROKEN_i386=	not for 32-bit systems, see https://github.com/darioizzo/audi/issues/62
 
 BUILD_DEPENDS=	audi>0:math/audi \
-		pybind11>0:devel/pybind11
+		pybind11>0:devel/pybind11 \
+		${PY_SETUPTOOLS}
 LIB_DEPENDS=	libabsl_base.so:devel/abseil \
 		libboost_serialization.so:devel/boost-libs \
 		libfmt.so:devel/libfmt \
 		libgmp.so:math/gmp \
 		libmp++.so:math/mppp \
 		libmpc.so:math/mpc \
 		libmpfr.so:math/mpfr \
 		libobake.so:math/obake \
 		libtbb.so:devel/onetbb
 
 USES=		cmake:testing compiler:c++20-lang python
 USE_PYTHON=	flavors
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	darioizzo
 GH_PROJECT=	audi
 
 WRKSRC_SUBDIR=	pyaudi
 
 CMAKE_OFF=	AUDI_BUILD_TESTS
 CMAKE_ARGS=	-DPYTHON_VERSION_MAJOR=3
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 do-test:
 	@${SETENV} ${TEST_ENV} ${PYTHON_CMD} ${FILESDIR}/test.py
 
 .include <bsd.port.mk>
diff --git a/misc/py-molequeue/Makefile b/misc/py-molequeue/Makefile
index 9906f97f8ac4..e084cd68478a 100644
--- a/misc/py-molequeue/Makefile
+++ b/misc/py-molequeue/Makefile
@@ -1,23 +1,24 @@
 PORTNAME=	molequeue
 DISTVERSION=	0.9.0
 PORTREVISION=	4
 CATEGORIES=	misc
 MASTER_SITES=	https://github.com/openchemistry/molequeue/releases/download/${DISTVERSION}/
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python binding for MolEqueue, task management framework
 WWW=		https://www.openchemistry.org/projects/molequeue
 
 LICENSE=	GPLv2
 LICENSE_FILE=	${WRKSRC}/../LICENSE
 
+BUILD_DEPENDS=	${PY_SETUPTOOLS}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pyzmq>0:net/py-pyzmq@${PY_FLAVOR}
 
 USES=		cmake compiler:c++11-lang python
 USE_PYTHON=	flavors
 
 NO_ARCH=	yes
 WRKSRC_SUBDIR=	python
 
 .include <bsd.port.mk>
diff --git a/net-p2p/c-lightning/Makefile b/net-p2p/c-lightning/Makefile
index d1d689c536e3..d5d2c281a417 100644
--- a/net-p2p/c-lightning/Makefile
+++ b/net-p2p/c-lightning/Makefile
@@ -1,141 +1,142 @@
 PORTNAME=	c-lightning
 # To build from an arbitrary git commit comment PORTVERSION and PORTREVISION (if present)
 PORTVERSION=	25.12.1
 DISTVERSIONPREFIX=	v
 PORTREVISION=	1
 # and uncomment the following two lines (use for example -git-HEAD or -git-f8d8348c)
 #PORTVERSION=	0
 #PKGNAMESUFFIX=	-git-f8d8348c
 CATEGORIES=	net-p2p finance
 
 MAINTAINER=	vd@FreeBSD.org
 COMMENT=	Lightning Network implementation in C
 WWW=		https://github.com/ElementsProject/lightning
 
 LICENSE=	MIT
 
 BUILD_DEPENDS=	bash:shells/bash \
 		gsed:textproc/gsed \
 		lowdown:textproc/lowdown \
 		jq:textproc/jq \
+		${PY_SETUPTOOLS} \
 		${PYTHON_PKGNAMEPREFIX}mako>=1.0.14:textproc/py-mako@${PY_FLAVOR}
 LIB_DEPENDS=	libsodium.so:security/libsodium
 RUN_DEPENDS=	bitcoin-cli:net-p2p/bitcoin-utils
 
 USES=		autoreconf:build \
 		compiler:c11 \
 		cpe \
 		gettext-tools:build \
 		gmake \
 		libtool \
 		python:build \
 		shebangfix
 CPE_VENDOR=	elementsproject
 BINARY_ALIAS=	python3=${PYTHON_CMD} sed=${LOCALBASE}/bin/gsed
 ALL_TARGET=	default
 SHEBANG_FILES=	tools/reckless
 
 OPTIONS_DEFINE=		COMPATIBILITY DEBUG RUST
 OPTIONS_MULTI=		STORAGE
 OPTIONS_MULTI_STORAGE=	POSTGRESQL SQLITE
 OPTIONS_RADIO=		TESTING
 OPTIONS_RADIO_TESTING=	ASAN VALGRIND
 OPTIONS_SUB=		yes
 
 COMPATIBILITY_CONFIGURE_ENABLE=	compat
 COMPATIBILITY_DESC=		Compatibility mode, good to disable to see if your software breaks
 DEBUG_CONFIGURE_ENABLE=		debugbuild
 DEBUG_DESC=			Extra debug checks in the build, good for testing
 POSTGRESQL_DESC=		Use PostgreSQL for storage
 POSTGRESQL_USES=		pgsql
 WANT_PGSQL=			client
 RUST_CONFIGURE_ENABLE=		rust
 RUST_DESC=			Install cln-grpc and clnrest plugins (Rust dependent)
 RUST_USES=			cargo
 RUST_BUILD_DEPENDS=		protobuf>=29:devel/protobuf
 CARGO_INSTALL=			no
 SQLITE_DESC=			Use SQLite for storage
 SQLITE_USES=			sqlite:3
 ASAN_CONFIGURE_ENABLE=		address-sanitizer
 ASAN_DESC=			Compile with address-sanitizer
 VALGRIND_CONFIGURE_ENABLE=	valgrind
 VALGRIND_DESC=			Run tests with Valgrind
 
 OPTIONS_DEFAULT=COMPATIBILITY RUST SQLITE
 
 .include <bsd.port.options.mk>
 
 HAS_CONFIGURE=	yes
 
 # Print the compilation commands (verbose).
 MAKE_ARGS=	V=1 mandir=${PREFIX}/share/man
 
 USE_GITHUB=	yes
 .if defined(PKGNAMESUFFIX)
 GIT_COMMIT=	${PKGNAMESUFFIX:C/-git-//}
 .else
 GIT_COMMIT=	${DISTVERSIONPREFIX}${PORTVERSION}
 .endif
 GH_TUPLE=	ElementsProject:lightning:${GIT_COMMIT} \
 		ElementsProject:libwally-core:12f5ac4ccf0e2:ext1/external/libwally-core \
 		BlockstreamResearch:secp256k1-zkp:615262261:ext2/external/libwally-core/src/secp256k1 \
 		ianlancetaylor:libbacktrace:793921876c981ce:ext3/external/libbacktrace \
 		zserge:jsmn:18e9fe42cbfe21d65076f5c77ae2be3:ext4/external/jsmn \
 		valyala:gheap:67fc83bc953324f4759e52951921d:ext5/external/gheap
 
 USERS=		c-lightning
 GROUPS=		c-lightning
 
 USE_RC_SUBR=	lightningd
 
 SUB_FILES=	lightningd-bitcoin.conf.sample pkg-message
 SUB_LIST=	U="${USERS}" G="${GROUPS}" LIGHTNINGD_BASE_DIR="${DESTDIR}/var/db/c-lightning"
 PLIST_SUB+=	U="${USERS}" G="${GROUPS}"
 
 .include <bsd.port.pre.mk>
 
 post-install:
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/bin/lightning-cli
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/bin/lightning-hsmtool
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/bin/lightningd
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/lightning_channeld
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/lightning_closingd
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/lightning_connectd
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/lightning_dualopend
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/lightning_gossipd
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/lightning_hsmd
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/lightning_onchaind
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/lightning_openingd
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/lightning_websocketd
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/autoclean
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/bcli
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/bookkeeper
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/chanbackup
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/cln-askrene
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/cln-renepay
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/cln-xpay
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/commando
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/exposesecret
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/funder
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/keysend
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/offers
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/pay
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/recklessrpc
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/recover
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/spenderp
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/sql
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/topology
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/txprepare
 .if ${PORT_OPTIONS:MRUST}
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/cln-bip353
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/cln-grpc
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/cln-lsps-client
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/cln-lsps-service
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/clnrest
 	${STRIP_CMD} ${STAGEDIR}${PREFIX}/libexec/c-lightning/plugins/wss-proxy
 .endif
 	${INSTALL_DATA} \
 		${WRKDIR}/lightningd-bitcoin.conf.sample \
 		${STAGEDIR}${PREFIX}/etc/lightningd-bitcoin.conf.sample
 
 .include <bsd.port.post.mk>
diff --git a/science/lammps/Makefile b/science/lammps/Makefile
index 9391e14c3780..d9d2ba2d95f0 100644
--- a/science/lammps/Makefile
+++ b/science/lammps/Makefile
@@ -1,155 +1,156 @@
 PORTNAME=	lammps
 PORTVERSION=	${GH_TAGNAME:C/(stable|patch)_([0-9]{1,2})([A-Z][a-z][a-z])([0-9]{4})/\4.\3.\2/S/Jan/01/S/Feb/02/S/Mar/03/S/Apr/04/S/May/05/S/Jun/06/S/Jul/07/S/Aug/08/S/Sep/09/S/Oct/10/S/Nov/11/S/Dec/12/S/_update/./:C/\.([1-9])$/.0\1/:S/.//g}
 PORTREVISION=	3
 CATEGORIES=	science
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Classical molecular dynamics code with a focus on materials modeling
 WWW=		https://lammps.sandia.gov/ \
 		https://github.com/lammps/lammps
 
 LICENSE=	GPLv2
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BROKEN_i386=	undefined reference to `__atomic_load'
 
 LIB_DEPENDS=	libevent.so:devel/libevent \
 		libfftw3.so:math/fftw3 \
 		libhwloc.so:devel/hwloc2 \
 		libnghttp2.so:www/libnghttp2 \
 		libpciaccess.so:devel/libpciaccess \
 		libssh2.so:security/libssh2 \
 		libzstd.so:archivers/zstd
+BUILD_DEPENDS=	${PY_SETUPTOOLS}
 
 .if !exists(/usr/include/omp.h)
 BROKEN=		requires OpenMP support that is missing on this architecture
 .endif
 
 USES=		blaslapack:openblas cmake:noninja,testing compiler:c++17-lang eigen:3 fortran gnome localbase:ldflags python shebangfix
 USE_GNOME=	libxml2
 USE_LDCONFIG=	yes
 USE_PYTHON=	cython
 
 USE_GITHUB=	yes
 GH_TAGNAME=	patch_19Nov2024
 
 SHEBANG_GLOB=	*.sh *.bash
 SHEBANG_FILES=	lib/kokkos/bin/nvcc_wrapper
 
 CMAKE_ON=	BUILD_SHARED_LIBS
 CMAKE_SOURCE_PATH=	${WRKSRC}/cmake
 CMAKE_ARGS=	-DBLA_VENDOR:STRING="OpenBLAS" ${CMAKE_ARGS_${CHOSEN_COMPILER_TYPE}} \
 		-DPython_EXECUTABLE=${PYTHON_CMD}
 CMAKE_ARGS_gcc=	-DBUILD_OMP:BOOL=false
 CMAKE_TESTING_ON=	ENABLE_TESTING # 3 tests fail, see https://github.com/lammps/lammps/issues/3875
 
 # enable packages (for a complete list see STANDARD_PACKAGES in cmake/CMakeLists.txt)
 CMAKE_ON+=	${LAMMPS_STANDARD_PACKAGES:S/^/PKG_/} # LAMMPS_STANDARD_PACKAGES is defined in Makefile.packages
 # Packages requiring extra downloades or dependencies: PKG_MSCG PKG_ADIOS PKG_MDI PKG_MESONT PKG_ML-PACE PKG_NETCDF PKG_ML-QUIP PKG_SCAFACOS PKG_VTK
 # PKG_ML-HDNNP downloads https://github.com/CompPhysVienna/n2p2/archive/v2.1.4.tar.gz
 
 OPTIONS_DEFINE=		EXCEPTIONS JPEG PNG GZIP FFMPEG
 OPTIONS_GROUP=		PARALLEL PACKAGES
 OPTIONS_DEFAULT=	EXCEPTIONS MPI OPENMP JPEG PNG GZIP FFMPEG H5MD KIM KOKKOS LATTE NETCDF PLUMED VORONOI ${OPTIONS_DEFAULT_${CHOSEN_COMPILER_TYPE}}
 OPTIONS_SUB=		yes
 PARALLEL_DESC=		Enable parallelizations:
 PACKAGES_DESC=		Enable packages:
 OPTIONS_GROUP_PARALLEL=	MPI OPENMP ${OPTIONS_DEFINE_${CHOSEN_COMPILER_TYPE}}
 OPTIONS_GROUP_PACKAGES=	H5MD KIM KOKKOS LATTE NETCDF PLUMED VORONOI VTK
 
 EXCEPTIONS_DESC=	Enable the use of C++ exceptions
 EXCEPTIONS_CMAKE_BOOL=	LAMMPS_EXCEPTIONS
 
 MPI_CMAKE_BOOL=		BUILD_MPI PKG_MPIIO
 MPI_LIB_DEPENDS=	libmpi_cxx.so:net/openmpi4
 MPI_USES=		compiler:c11
 
 FFMPEG_CMAKE_BOOL=	WITH_FFMPEG
 FFMPEG_BUILD_DEPENDS=	ffmpeg:multimedia/ffmpeg
 FFMPEG_RUN_DEPENDS=	ffmpeg:multimedia/ffmpeg
 
 JPEG_CMAKE_BOOL=	WITH_JPEG
 JPEG_USES=		jpeg
 
 PNG_CMAKE_BOOL=		WITH_PNG
 PNG_LIB_DEPENDS=	libpng.so:graphics/png
 
 GZIP_DESC=		Enable GZIP support
 GZIP_CMAKE_BOOL=	WITH_GZIP
 
 H5MD_DESC=		H5MD package based on the libhdf5 library
 H5MD_CMAKE_BOOL=	PKG_H5MD
 H5MD_LIB_DEPENDS=	libhdf5.so:science/hdf5
 
 KIM_DESC=		KIM package based on the OpenKim library/repository
 KIM_USES=		pkgconfig
 KIM_CMAKE_BOOL=		PKG_KIM
 KIM_CMAKE_ON=		-DDOWNLOAD_KIM:BOOL=OFF
 KIM_LIB_DEPENDS=	libkim-api.so:science/kim-api \
 			libcurl.so:ftp/curl
 KIM_RUN_DEPENDS=	openkim-models>0:science/openkim-models
 
 KOKKOS_DESC=		Kokkos package based on the libkokkos library
 KOKKOS_CMAKE_BOOL=	PKG_KOKKOS EXTERNAL_KOKKOS
 KOKKOS_LIB_DEPENDS=	libkokkoscore.so:devel/kokkos
 
 LATTE_DESC=		Latte package based on the liblatte library
 LATTE_CMAKE_BOOL=	PKG_LATTE
 LATTE_LIB_DEPENDS=	liblatte.so:science/latte
 
 NETCDF_DESC=		NetCDF package based on the NetCDF library
 NETCDF_CMAKE_BOOL=	PKG_NETCDF
 NETCDF_LIB_DEPENDS=	libnetcdf.so:science/netcdf
 
 PLUMED_DESC=		Plumed package based on the plumed library
 PLUMED_USES=		pkgconfig
 PLUMED_CMAKE_BOOL=	PKG_PLUMED
 PLUMED_CMAKE_ON=	-DPLUMED_MODE=shared
 PLUMED_LIB_DEPENDS=	libplumed.so:science/plumed
 
 VORONOI_DESC=		Voro++, Voronoi tessellation package
 VORONOI_CMAKE_BOOL=	PKG_VORONOI
 VORONOI_LIB_DEPENDS=	libvoro++.so:science/voro++
 
 VTK_DESC=		VTK package based on the external VTK-${VTK_VER:R} library
 VTK_CMAKE_BOOL=		PKG_VTK
 VTK_CMAKE_ON=		-DVTK_DIR:PATH=${LOCALBASE}/lib/cmake/vtk-${VTK_VER}
 VTK_USES=		gl qt:5 xorg
 VTK_USE=		GL=opengl qt=core,declarative,gui,network,opengl,sql,widgets xorg=ice,sm,x11,xext,xt
 VTK_LIB_DEPENDS=	libvtkCommonCore-${VTK_VER}.so:math/vtk${VTK_VER:R} \
 			libexpat.so:textproc/expat2 \
 			libfreetype.so:print/freetype2 \
 			libtiff.so:graphics/tiff
 
 PORTSCOUT=	ignore:1 # due to a special version tagging scheme that this project uses portscout fails to find new versions, watching their GitHub release page instead
 
 .include <bsd.port.options.mk>
 
 .if ${PORT_OPTIONS:MOPENMP}
 CMAKE_ARGS+=	-DBUILD_OMP:BOOL=true
 .endif
 
 xpost-patch:
 	# adjust SHELL in Makefile
 	@${REINPLACE_CMD} 's|SHELL = /bin/bash|SHELL = ${LOCALBASE}/bin/bash|' ${WRKSRC}/src/Makefile
 	# fix python version, also see https://github.com/lammps/lammps/issues/3098, https://github.com/lammps/lammps/issues/3099
 	@${FIND} ${WRKSRC} -name "CMakeLists.txt" -o -name "*.cmake" | ${XARGS} ${REINPLACE_CMD} -e ' \
 		s|find_package(Python3 REQUIRED |find_package(Python $${FREEBSD_PYTHON_VER} EXACT REQUIRED |; \
 		s|find_package(Python 3.5 COMPONENTS |find_package(Python $${FREEBSD_PYTHON_VER} EXACT COMPONENTS |; \
 		s|find_package(Python 3.6 COMPONENTS |find_package(Python $${FREEBSD_PYTHON_VER} EXACT COMPONENTS |; \
 		s|find_package(Python3 REQUIRED |find_package(Python $${FREEBSD_PYTHON_VER} EXACT REQUIRED |; \
 		s|find_package(Python COMPONENTS |find_package(Python3 $${FREEBSD_PYTHON_VER} EXACT COMPONENTS |; \
 		s|find_package(Python3 COMPONENTS |find_package(Python3 $${FREEBSD_PYTHON_VER} EXACT COMPONENTS |; \
 		s|find_package(Python QUIET COMPONENTS |find_package(Python3 $${FREEBSD_PYTHON_VER} EXACT QUIET COMPONENTS |; \
 		s|find_package(Python REQUIRED COMPONENTS |find_package(Python3 $${FREEBSD_PYTHON_VER} EXACT REQUIRED COMPONENTS | \
 		'
 
 post-patch-FFMPEG-off:
 	@${REINPLACE_CMD} 's|find_program(FFMPEG_EXECUTABLE|#&|' ${WRKSRC}/cmake/CMakeLists.txt
 
 post-install:
 	@${RM} -r ${STAGEDIR}${PREFIX}/lib/python*
 
 .include "Makefile.packages"
 .include <../../math/vtk9/Makefile.version>
 .include <bsd.port.mk>
diff --git a/science/tweedledum/Makefile b/science/tweedledum/Makefile
index 7abd175216fc..7ad907c5fb0a 100644
--- a/science/tweedledum/Makefile
+++ b/science/tweedledum/Makefile
@@ -1,28 +1,30 @@
 PORTNAME=	tweedledum
 DISTVERSIONPREFIX=	v
 DISTVERSION=	1.1.1
 CATEGORIES=	science python # quantum-computing
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Library for analysis, compilation, synthesis of quantum circuits
 WWW=		https://github.com/boschmitt/tweedledum
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-USES=		cmake:testing compiler:c++17-lang
+BUILD_DEPENDS=	${PY_SETUPTOOLS}
+
+USES=		cmake:testing compiler:c++17-lang python:env
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	boschmitt
 
 CMAKE_OFF=	TWEEDLEDUM_PYBINDS # doesn't affect the build result, see https://github.com/boschmitt/tweedledum/issues/175
 CMAKE_ON=	BUILD_SHARED_LIBS
 CMAKE_TESTING_ON=	TWEEDLEDUM_TESTS
 CMAKE_TESTING_TARGET=	${ALL_TARGET} # hack to disable the target
 
 TEST_WRKSRC=	${BUILD_WRKSRC}/tests
 
 post-test: # run tests, all tests pass with 3313 assertions in 73 test cases, see https://github.com/boschmitt/tweedledum/issues/177
 	@cd ${TEST_WRKSRC} && ./run_tests
 
 .include <bsd.port.mk>
diff --git a/textproc/redland-bindings/Makefile b/textproc/redland-bindings/Makefile
index 8e658c83fe01..e8932f1d628b 100644
--- a/textproc/redland-bindings/Makefile
+++ b/textproc/redland-bindings/Makefile
@@ -1,34 +1,35 @@
 PORTNAME=	redland-bindings
 PORTVERSION=	1.0.17.1
 PORTREVISION=	4
 CATEGORIES=	textproc
 MASTER_SITES=	http://download.librdf.org/source/
 
 MAINTAINER=	office@FreeBSD.org
 COMMENT=	Language bindings for the Redland package
 WWW=		https://librdf.org/bindings/
 
 # Even though GPLv3 is not explicitly mentioned in the port's LICENSE.html, one
 # of its licenses is "GPLv2 or newer", which includes GPLv3.
 LICENSE=	APACHE20 GPLv2 GPLv3 LGPL21
 LICENSE_COMB=	dual
 
 LIB_DEPENDS=	librdf.so:textproc/redland \
 		libraptor2.so:textproc/raptor2 \
 		librasqal.so:textproc/rasqal
 
 GNU_CONFIGURE=	yes
 USES=		pkgconfig
 
 OPTIONS_DEFINE=	PHP PYTHON RUBY
 OPTIONS_DEFAULT=PYTHON
 OPTIONS_SUB=	yes
 
 PHP_CONFIGURE_WITH=	php
 PHP_USES=		php:build
+PYTHON_BUILD_DEPENDS=	${PY_SETUPTOOLS}
 PYTHON_CONFIGURE_WITH=	python python-libext=${PYTHON_TAG}.so
 PYTHON_USES=		python
 RUBY_CONFIGURE_WITH=	ruby
 RUBY_USES=		ruby
 
 .include <bsd.port.mk>