diff --git a/biology/vsearch/Makefile b/biology/vsearch/Makefile
index cd8ded144f80..89285b62f813 100644
--- a/biology/vsearch/Makefile
+++ b/biology/vsearch/Makefile
@@ -1,32 +1,32 @@
 # $FreeBSD$
 
 PORTNAME=		vsearch
 DISTVERSIONPREFIX=	v
-DISTVERSION=		2.15.2
+DISTVERSION=		2.16.0
 CATEGORIES=		biology
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Versatile open-source tool for metagenomics
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 # Note: For PPC need power8 or later, little endian
 ONLY_FOR_ARCHS=		aarch64 amd64
 ONLY_FOR_ARCHS_REASON=	Explicitly enumerated by upstream developers
 
 LIB_DEPENDS=	libsysinfo.so:devel/libsysinfo
 
 USES=		autoreconf ghostscript:build gmake localbase
 USE_GITHUB=	yes
 
 GH_ACCOUNT=	torognes
 GNU_CONFIGURE=	yes
 
 PLIST_FILES=	bin/vsearch man/man1/vsearch.1.gz
 PORTDOCS=	*
 
 OPTIONS_DEFINE=	DOCS
 OPTIONS_SUB=	yes
 
 .include <bsd.port.mk>
diff --git a/biology/vsearch/distinfo b/biology/vsearch/distinfo
index 200d62123ac3..2858c232496e 100644
--- a/biology/vsearch/distinfo
+++ b/biology/vsearch/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1612019512
-SHA256 (torognes-vsearch-v2.15.2_GH0.tar.gz) = ce821f5f870c00938ddc0938ba5a13f17e697a9ddd1d53cfbebd276ae4c640c8
-SIZE (torognes-vsearch-v2.15.2_GH0.tar.gz) = 242701
+TIMESTAMP = 1616532721
+SHA256 (torognes-vsearch-v2.16.0_GH0.tar.gz) = b90247f8d522b995406d45b256c9d0254ab05420726e238414632a2ec9444e4f
+SIZE (torognes-vsearch-v2.16.0_GH0.tar.gz) = 245798