diff --git a/biology/vsearch/Makefile b/biology/vsearch/Makefile
index 54f34f6f2c93..967a7e75d93d 100644
--- a/biology/vsearch/Makefile
+++ b/biology/vsearch/Makefile
@@ -1,29 +1,29 @@
 PORTNAME=		vsearch
 DISTVERSIONPREFIX=	v
-DISTVERSION=		2.30.2
+DISTVERSION=		2.30.3
 CATEGORIES=		biology
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Versatile open-source tool for metagenomics
 WWW=		https://github.com/torognes/vsearch
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 ONLY_FOR_ARCHS=		aarch64 amd64 powerpc64le
 ONLY_FOR_ARCHS_REASON=	Explicitly enumerated by upstream developers
 
 USES=		autoreconf ghostscript:build gmake localbase
 USE_GITHUB=	yes
 
 GH_ACCOUNT=	torognes
 GNU_CONFIGURE=	yes
 GNU_CONFIGURE_MANPREFIX=	${PREFIX}/share
 
 PLIST_FILES=	bin/vsearch share/man/man1/vsearch.1.gz
 PORTDOCS=	*
 
 OPTIONS_DEFINE=	DOCS
 OPTIONS_SUB=	yes
 
 .include <bsd.port.mk>
diff --git a/biology/vsearch/distinfo b/biology/vsearch/distinfo
index fa8f653b59b7..42c13250edd5 100644
--- a/biology/vsearch/distinfo
+++ b/biology/vsearch/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1766069466
-SHA256 (torognes-vsearch-v2.30.2_GH0.tar.gz) = f4c244d2b48637e9a42325901b832ca5b6522cec8e2006b0da2aa9b9a0b5e699
-SIZE (torognes-vsearch-v2.30.2_GH0.tar.gz) = 334780
+TIMESTAMP = 1768310816
+SHA256 (torognes-vsearch-v2.30.3_GH0.tar.gz) = 6ea0873fee8360b47bcad860ea1565cbfec4ed239a66f159610371d2836d5679
+SIZE (torognes-vsearch-v2.30.3_GH0.tar.gz) = 335610
diff --git a/biology/vsearch/files/patch-src_arch.cc b/biology/vsearch/files/patch-src_arch.cc
deleted file mode 100644
index bf8d2e77dda7..000000000000
--- a/biology/vsearch/files/patch-src_arch.cc
+++ /dev/null
@@ -1,32 +0,0 @@
---- src/arch.cc.orig	2025-12-20 13:37:07 UTC
-+++ src/arch.cc
-@@ -67,7 +67,7 @@
- #include <cstdlib>  // std::realloc, std::free
- 
- 
--constexpr auto memalignment = 16;
-+constexpr auto vsearch_memalignment = 16;
- 
- 
- auto arch_get_memused() -> uint64_t
-@@ -223,9 +223,9 @@ auto xmalloc(std::size_t size) -> void *
-   size = std::max(size, minimal_allocation);
-   void * ptr = nullptr;
- #ifdef _WIN32
--  ptr = _aligned_malloc(size, memalignment);
-+  ptr = _aligned_malloc(size, vsearch_memalignment);
- #else
--  if (posix_memalign(&ptr, memalignment, size) != 0)
-+  if (posix_memalign(&ptr, vsearch_memalignment, size) != 0)
-     {
-       ptr = nullptr;
-     }
-@@ -243,7 +243,7 @@ auto xrealloc(void * ptr, std::size_t size) -> void *
-   static constexpr auto minimal_allocation = std::size_t{1};
-   size = std::max(size, minimal_allocation);
- #ifdef _WIN32
--  void * new_ptr = _aligned_realloc(ptr, size, memalignment);
-+  void * new_ptr = _aligned_realloc(ptr, size, vsearch_memalignment);
- #else
-   void * new_ptr = realloc(ptr, size);
- #endif