diff --git a/science/py-chempy/Makefile b/science/py-chempy/Makefile
index f8038dcc66d8..c305778ba14d 100644
--- a/science/py-chempy/Makefile
+++ b/science/py-chempy/Makefile
@@ -1,53 +1,53 @@
 PORTNAME=	chempy
-DISTVERSION=	0.9.0
-PORTREVISION=	3
+DISTVERSION=	0.10.1
 CATEGORIES=	science python # chemistry
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Package useful for solving problems in chemistry
 WWW=		https://github.com/bjodah/chempy
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 PY_DEPENDS=	${PYTHON_PKGNAMEPREFIX}dot2tex>=2.11.3:print/dot2tex@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}matplotlib>=2.2.3:math/py-matplotlib@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}PuLP>=1.6.8:math/py-PuLP@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}pyneqsys>=0.5.5:math/py-pyneqsys@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}pyneqsys>=0.5.7:math/py-pyneqsys@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pyodesys>=0.14.1:math/py-pyodesys@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pyparsing>=2.0.3:devel/py-pyparsing@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}quantities>=0.12.1:science/py-quantities@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=1.0.1:science/py-scipy@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}sym>=0.3.4:math/py-sym@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}sympy>=1.1.1:math/py-sympy@${PY_FLAVOR}
+		${PYTHON_PKGNAMEPREFIX}sym>=0.3.7:math/py-sym@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}sympy>=1.1.1:math/py-sympy@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}tabulate>0:devel/py-tabulate@${PY_FLAVOR}
 BUILD_DEPENDS=	${PY_DEPENDS}
 RUN_DEPENDS=	${PY_DEPENDS}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}black>0:devel/py-black@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-cov>0:devel/py-pytest-cov@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-flakes>0:devel/py-pytest-flakes@${PY_FLAVOR} \
 		gsl>0:math/gsl
 
 USES=		localbase:ldflags python # localbase and math/gsl are only for tests
 USE_PYTHON=	distutils autoplist pytest # 5 tests fail, see https://github.com/bjodah/chempy/issues/222
 
 NO_ARCH=	yes
 
 CONFLICTS_INSTALL=	${PYTHON_PKGNAMEPREFIX}pymol # https://github.com/schrodinger/pymol-open-source/issues/100
 
 OPTIONS_DEFINE=		EXTRAS
 OPTIONS_DEFAULT=	EXTRAS
 
-EXTRAS_DESC=		Install optional dependencies for additional functionality
+EXTRAS_DESC=		Install optional dependencies for additional functionality # this seems to be a copy of what extras pyodesys requires, see https://github.com/bjodah/chempy/issues/241
 EXTRAS_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}appdirs>0:devel/py-appdirs@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}bokeh>=0.13.0:www/py-bokeh@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}ipywidgets>0:devel/py-ipywidgets@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}pycodeexport>=0.1.3:devel/py-pycodeexport@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}pycompilation>=0.4.12:devel/py-pycompilation@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}pygslodeiv2>=0.9.4:math/py-pygslodeiv2@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}pyodeint>=0.10.4:math/py-pyodeint@${PY_FLAVOR}
 			# TODO pycvodes>=0.14.0, pykinsol>=0.1.6
 
 .include <bsd.port.mk>
diff --git a/science/py-chempy/distinfo b/science/py-chempy/distinfo
index 1ac919ccffb9..0cd0f9b75f33 100644
--- a/science/py-chempy/distinfo
+++ b/science/py-chempy/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1714020842
-SHA256 (chempy-0.9.0.tar.gz) = 3ba07d597fef672f3dea4c3ce81e64683f90afd263a7962a6d0db2ab8d9a0204
-SIZE (chempy-0.9.0.tar.gz) = 184714
+TIMESTAMP = 1761714393
+SHA256 (chempy-0.10.1.tar.gz) = 7112a2fe6cfe49730870de19e6061ff7f174a7d626a64244ab0505afa591cba0
+SIZE (chempy-0.10.1.tar.gz) = 428230