diff --git a/biology/py-pysam/Makefile b/biology/py-pysam/Makefile
index 112e7ab168be..debed1535b41 100644
--- a/biology/py-pysam/Makefile
+++ b/biology/py-pysam/Makefile
@@ -1,20 +1,24 @@
 PORTNAME=	pysam
 DISTVERSION=	0.19.1
+PORTREVISION=	1
 CATEGORIES=	biology python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
+PATCH_SITES=	https://github.com/pysam-developers/pysam/commit/
+PATCHFILES=	064c8024395a15024fd590bd90f55f918e15545f.patch:-p1 # backport of symbols failure fix for arm and risc
+
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python module for reading, manipulating and writing genomic data sets
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/COPYING
 
 # see https://github.com/pysam-developers/pysam/issues/1121 for below failures
 BROKEN_aarch64=	conflicting symbol (libchtslib libcsamtools ...) : $d.6
 BROKEN_riscv6=	conflicting symbol (libchtslib libcsamtools ...): .Lline_table_start0
 
 USES=		gmake python:3.6-3.9
 USE_PYTHON=	autoplist distutils cython cython_run
 
 .include <bsd.port.mk>
diff --git a/biology/py-pysam/distinfo b/biology/py-pysam/distinfo
index b0745a6421bb..e92952ac8d70 100644
--- a/biology/py-pysam/distinfo
+++ b/biology/py-pysam/distinfo
@@ -1,3 +1,5 @@
-TIMESTAMP = 1653951817
+TIMESTAMP = 1658245018
 SHA256 (pysam-0.19.1.tar.gz) = dee403cbdf232170c1e11cc24c76e7dd748fc672ad38eb0414f3b9d569b1448f
 SIZE (pysam-0.19.1.tar.gz) = 3857553
+SHA256 (064c8024395a15024fd590bd90f55f918e15545f.patch) = e4655d70d0debe00f7937b9b3f18318acbcb8ae832165542c1531233320c6df7
+SIZE (064c8024395a15024fd590bd90f55f918e15545f.patch) = 1237