diff --git a/biology/py-htseq/Makefile b/biology/py-htseq/Makefile
index 311252464790..1b7e1d2a138b 100644
--- a/biology/py-htseq/Makefile
+++ b/biology/py-htseq/Makefile
@@ -1,32 +1,30 @@
 PORTNAME=	HTSeq
-DISTVERSION=	2.0.9
-PORTREVISION=	2
+DISTVERSION=	2.1.2
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	${PORTNAME:tl}-${DISTVERSION}
 
 MAINTAINER=	alven@FreeBSD.org
 COMMENT=	Python library to facilitate programmatic analysis of sequence data
 WWW=		https://github.com/htseq/htseq/
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}pysam>0:biology/py-pysam@${PY_FLAVOR}
-RUN_DEPENDS=	${PYNUMPY} \
-		${PYTHON_PKGNAMEPREFIX}pysam>0:biology/py-pysam@${PY_FLAVOR} \
-		${PKGNAMEPREFIX}matplotlib>=1.4.3:math/py-matplotlib@${PY_FLAVOR}
-TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}scipy>1.5.0:science/py-scipy@${PY_FLAVOR} \
+RUN_DEPENDS=	${PKGNAMEPREFIX}matplotlib>=1.4.3:math/py-matplotlib@${PY_FLAVOR} \
+		${PYNUMPY} \
+		${PYTHON_PKGNAMEPREFIX}pysam>0:biology/py-pysam@${PY_FLAVOR}
+TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}matplotlib>=1.4:math/py-matplotlib@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pandas>=1.1.0:math/py-pandas@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}matplotlib>=1.4:math/py-matplotlib@${PY_FLAVOR}
+		${PYTHON_PKGNAMEPREFIX}scipy>1.5.0:science/py-scipy@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	autoplist cython distutils pytest
 
 post-stage:
-	${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/HTSeq/_StepVector.cpython-${PYTHON_SUFFIX}.so
-	${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/HTSeq/_HTSeq.cpython-${PYTHON_SUFFIX}.so
+	${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/${PORTNAME}/*.so
 
 .include <bsd.port.mk>
diff --git a/biology/py-htseq/distinfo b/biology/py-htseq/distinfo
index 3afeb0581588..0356d066b903 100644
--- a/biology/py-htseq/distinfo
+++ b/biology/py-htseq/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1732713260
-SHA256 (htseq-2.0.9.tar.gz) = 3bbec23f033d35f40ab33a40c2b5c43f75e382c424b804c099dea635b52c2b12
-SIZE (htseq-2.0.9.tar.gz) = 468908
+TIMESTAMP = 1770360620
+SHA256 (htseq-2.1.2.tar.gz) = 69d5a6b9a832ea85edf8a32fbac591a8af2e32bb961d1f3843c48c9d03a77a82
+SIZE (htseq-2.1.2.tar.gz) = 506243