diff --git a/devel/py-llvmlite/Makefile b/devel/py-llvmlite/Makefile
index db32cce8172c..14bc4cf3525a 100644
--- a/devel/py-llvmlite/Makefile
+++ b/devel/py-llvmlite/Makefile
@@ -1,26 +1,33 @@
 PORTNAME=	llvmlite
-DISTVERSION=	0.44.0
-PORTREVISION=	1
+DISTVERSION=	0.46.0
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	makc@FreeBSD.org
 COMMENT=	Lightweight LLVM python binding for writing JIT compilers
 WWW=		https://github.com/numba/llvmlite
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
+BUILD_DEPENDS=	gmake:devel/gmake
+
 # llvm compatibility table https://github.com/numba/llvmlite#compatibility
-USES=		compiler:c++11-lib fortran llvm:15,build,run python
+USES=		cmake:indirect fortran llvm:20,lib python
 USE_PYTHON=	distutils autoplist pytest # many tests fail, see https://github.com/numba/llvmlite/issues/1015
 
-MAKE_ENV=	LLVM_CONFIG=${LLVM_CONFIG}
+MAKE_ENV=	LLVM_CONFIG=${LLVM_CONFIG} \
+		LLVMLITE_SHARED=ON \
+		CMAKE_ARGS=-DCMAKE_VERBOSE_MAKEFILE:BOOL=ON
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
+post-patch:
+# Use required LLVM if multiple variants are present.
+	${REINPLACE_CMD} "s,%%LLVM_PREFIX%%,${LLVM_PREFIX}," ${WRKSRC}/ffi/CMakeLists.txt
+
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/llvmlite/binding/libllvmlite*.so
 
 .include <bsd.port.mk>
diff --git a/devel/py-llvmlite/distinfo b/devel/py-llvmlite/distinfo
index 685f05b07909..a327e74eb6d3 100644
--- a/devel/py-llvmlite/distinfo
+++ b/devel/py-llvmlite/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1738000508
-SHA256 (llvmlite-0.44.0.tar.gz) = 07667d66a5d150abed9157ab6c0b9393c9356f229784a4385c02f99e94fc94d4
-SIZE (llvmlite-0.44.0.tar.gz) = 171880
+TIMESTAMP = 1768596780
+SHA256 (llvmlite-0.46.0.tar.gz) = 227c9fd6d09dce2783c18b754b7cd9d9b3b3515210c46acc2d3c5badd9870ceb
+SIZE (llvmlite-0.46.0.tar.gz) = 193456
diff --git a/devel/py-llvmlite/files/patch-ffi_CMakeLists.txt b/devel/py-llvmlite/files/patch-ffi_CMakeLists.txt
new file mode 100644
index 000000000000..c3d7c41dc685
--- /dev/null
+++ b/devel/py-llvmlite/files/patch-ffi_CMakeLists.txt
@@ -0,0 +1,11 @@
+--- ffi/CMakeLists.txt.orig	2025-12-08 17:44:54 UTC
++++ ffi/CMakeLists.txt
+@@ -18,7 +18,7 @@ set(CMAKE_C_VISIBILITY_PRESET "hidden")
+ set(CMAKE_CXX_VISIBILITY_PRESET "hidden")
+ set(CMAKE_C_VISIBILITY_PRESET "hidden")
+ 
+-find_package(LLVM REQUIRED CONFIG)
++find_package(LLVM REQUIRED CONFIG HINTS %%LLVM_PREFIX%%)
+ 
+ message(STATUS "Found LLVM ${LLVM_PACKAGE_VERSION}")
+ message(STATUS "Using LLVMConfig.cmake in: ${LLVM_DIR}")