diff --git a/Mk/Uses/python.mk b/Mk/Uses/python.mk
index b8378ce3e845..6e0efd8bccfb 100644
--- a/Mk/Uses/python.mk
+++ b/Mk/Uses/python.mk
@@ -1,1002 +1,1024 @@
 # Provide support for Python related ports. This includes detecting Python
 # interpreters, ports providing package and modules for python as well as
 # consumer ports requiring Python at build or run time.
 #
 # Feature:	python
 # Usage:	USES=python[:version-spec][,arg,...]
 # Valid ARGS:	<version-spec>, patch, build, run, test, env
 #
 # version-spec 	Declarative specification for the Python version(s) the
 #		port supports. Subsets and ranges can be specified:
 #
 #			* <version>
 #			* <minimum-version>-<maximum-version>
 #			* <minimum-version>+
 #			* -<maximum-version>
 #
 #		Examples:
 #
 #			USES=python:2.7		# Supports Python 2.7 Only
 #			USES=python:3.9+	# Supports Python 3.9 or later
 #			USES=python:3.9-3.10	# Supports Python 3.9 to 3.10
 #			USES=python:-3.9	# Supports Python up to 3.9
 #			USES=python		# Supports 3.9+
 #
 # NOTE:	<version-spec> should be as specific as possible, matching the versions
 #	upstream declares support for, without being incorrect. In particular,
 #	USES=python *without* a <version-spec> means 3.9+,
 #	including unreleased versions, which is probably incorrect.
 #
 #	Not specifying a <version-spec> should only be used when a more specific
 #	<version-spec> cannot be specified due to syntax limitations, for
 #	example: 2.7,3.9-3.10, but even in this case, X.Y+ (2.7+), or -X.Y (-3.9)
 #	is preferred and likely more correct.
 #
 # patch		Python is needed at patch time. Adds dependency to PATCH_DEPENDS.
 # build		Python is needed at build time. Adds dependency to BUILD_DEPENDS.
 # run		Python is needed at run time. Adds dependency to RUN_DEPENDS.
 # test		Python is needed at test time. Adds dependency to TEST_DEPENDS.
 # env		Does not depend on Python but needs the environment set up. This
 #		is mainly used when depending on flavored python ports, or when a
 #		correct PYTHON_CMD is required.  It has the same effect as setting
 #		PYTHON_NO_DEPENDS.
 #
 # If build, run and test are omitted, Python will be added as BUILD_DEPENDS,
 # RUN_DEPENDS and TEST_DEPENDS.
 # patch is independant, it does not prevent the default build/run/test
 # dependency.
 # env or PYTHON_NO_DEPENDS can be set to not add any dependencies.
 #
 # Exported variables:
 #
 # PYTHON_VERSION	- The chosen Python interpreter including the version,
 #			  e.g. python2.7, python3.9, etc.
 #
 # Variables, which can be set by the port:
 #
 # USE_PYTHON		- A list of additional features and functionality to
 #			  enable. Supported features are:
 #
 #	concurrent 	- Indicates that the port can be installed for
 #			  different python versions at the same time. The port
 #			  is supposed to use a unique prefix for certain
 #			  directories using USES=uniquefiles:dirs (see the
 #			  uniquefiles.mk Uses for details about the
 #			  directories), if set to yes. Binaries receive an
 #			  additional suffix, based on ${PYTHON_VER}.
 #
 #			  The values for the uniquefiles USES are set as
 #			  follows:
 #
 #				UNIQUE_PREFIX=  ${PYTHON_PKGNAMEPREFIX}
 #				UNIQUE_SUFFIX=  -${PYTHON_VER}
 #
 #			  If the port is installed for the current default
 #			  python version, scripts and binaries in
 #
 #				${PREFIX}/bin
 #				${PREFIX}/sbin
 #				${PREFIX}/libexec
 #
 #			  are linked from the prefixed version to the
 #			  prefix-less original name, e.g.
 #			  bin/foo-2.7 --> bin/foo.
 #
 #	cryptography_build
 #			- Depend on security/cryptography at build-time.
 #
 #	cryptography	- Depend on security/cryptography at run-time.
 #
 #	cryptography_test
 #			- Depend on security/cryptography at test-time.
 #
 #	cython		- Depend on lang/cython at build-time.
 #
 #	cython_run	- Depend on lang/cython at run-time.
 #
 #	cython_test	- Depend on lang/cython for tests.
 #
+#	cython3		- Depend on lang/cython3 at build-time.
+#
+#	cython3_run	- Depend on lang/cython3 at run-time.
+#
+#	cython3_test	- Depend on lang/cython3 for tests.
+#
 #	flavors		- Force creation of flavors for Python 2 and 3 default
 #			  versions, where applicable.
 #
 #	noflavors	- Disable automatic creation of flavors if they would
 #			  otherwise be created and they are not wanted.
 #
 #	allflavors 	- Generate flavors for all possible versions and not
 #			  simply the default ones.  Only to be used for py-*
 #			  ports that are part of the Python distribution, but
 #			  kept as separate ports.
 #
 #	optsuffix	- Set PKGNAMESUFFIX to PYTHON_PKGNAMESUFFIX if not the
 #			  default python version.
 #
 #	distutils	- Use distutils as do-configure, do-build and
 #			  do-install targets. implies flavors.
 #
 #	pep517		- Follow the PEP-517 standard to build and install wheels
 #			  as do-build and do-install targets. implies flavors.
 #
 #	autoplist	- Automatically generates the packaging list for a
 #			  port that uses distutils when defined.
 #			  requires: distutils
 #
 #	py3kplist	- Automatically generates Python 3.x compatible
 #			  __pycache__ entries from a Python 2.x packaging list
 #			  when defined. Use this for ports that do *not* use
 #			  standard Python packaging mechanisms such as
 #			  distutils, and support *both* Python 2.x and 3.x.
 #			  Not needed, if USE_PYTHON=autoplist is set.
 #
 #	pythonprefix	- Says that the port installs in ${PYTHONBASE} instead
 #			  of ${PREFIX}.
 #
 #	noegginfo	- Skip an egg-info entry from plist, if defined.
 #
 #	nose		- Run tests with nose (devel/py-nose)
 #
 #	nose2		- Run tests with nose2 (devel/py-nose2)
 #
 #	pytest		- Run tests with latest pytest (devel/py-pytest)
 #
 #	pytest4		- Run tests with pytest 4.x (devel/py-pytest4)
 #
 #	unittest	- Run tests with unittest
 #
 #	unittest2	- Run tests with unittest2 (devel/py-unittest2)
 #
 # PYTHON_CMD		- Python's command line file name, including the
 #			  version number (used for dependencies).
 #			  default: ${PYTHONBASE}/bin/${PYTHON_VERSION}
 #
 # PEP517_BUILD_CMD	- Command sequence for a PEP-517 build frontend that builds a wheel.
 #			  default: ${PYTHON_CMD} -m build --no-isolation --wheel ${PEP517_BUILD_CONFIG_SETTING}
 #
 # PEP517_BUILD_DEPEND	- Port needed to execute ${PEP517_BUILD_CMD}.
 #			  default: ${PYTHON_PKGNAMEPREFIX}build>=0:devel/py-build@${PY_FLAVOR}
 #
 # PEP517_BUILD_CONFIG_SETTING
 #			- Options for the build backend. Must include -C or --config-setting per option.
 #			  default: <empty>
 #
 # PEP517_INSTALL_CMD	- Command sequence for a PEP-517 install frontend that installs a wheel.
 #			  default: ${PYTHON_CMD} -m installer --destdir ${STAGEDIR} --prefix ${PREFIX} ${BUILD_WRKSRC}/dist/${PORTNAME:C|[-_]+|_|g}-${DISTVERSION}*.whl
 #
 # PEP517_INSTALL_DEPEND	- Port needed to execute ${PEP517_INSTALL_CMD}.
 #			  default: ${PYTHON_PKGNAMEPREFIX}installer>=0:devel/py-installer@${PY_FLAVOR}
 #
 # PYSETUP		- Name of the setup script used by the distutils
 #			  package.
 #			  default: setup.py
 #
 # PYDISTUTILS_PKGNAME
 #			- Internal name in the distutils for egg-info.
 #			  default: ${PORTNAME}
 #
 # PYDISTUTILS_PKGVERSION
 #			- Internal version in the distutils for egg-info.
 #			  default: ${PORTVERSION}
 #
 # PYDISTUTILS_CONFIGURE_TARGET
 #			- Pass this command to distutils on configure stage.
 #			  default: config
 #
 # PYDISTUTILS_BUILD_TARGET
 #			- Pass this command to distutils on build stage.
 #			  default: build
 #
 # PYDISTUTILS_INSTALL_TARGET
 #			- Pass this command to distutils on install stage.
 #			  default: install
 #
 # PYDISTUTILS_CONFIGUREARGS
 #			- Arguments to config with distutils.
 #			  default: <empty>
 #
 # PYDISTUTILS_BUILDARGS
 #			- Arguments to build with distutils.
 #			  default: <empty>
 #
 # PYDISTUTILS_INSTALLARGS
 #			- Arguments to install with distutils.
 #			  default: -c -O1 --prefix=${PREFIX} --single-version-externally-managed --root=${STAGEDIR}
 #
 # PYDISTUTILS_EGGINFO
 #			- Canonical name for egg-info.
 #			  default: ${PYDISTUTILS_PKGNAME:C/[^A-Za-z0-9.]+/_/g}-${PYDISTUTILS_PKGVERSION:C/[^A-Za-z0-9.]+/_/g}-py${PYTHON_VER}.egg-info
 #
 # PYTEST_BROKEN_TESTS	- Lists of 'pytest -k' patterns to skip tests which
 #			  require fixing.
 #			  default: <empty>
 #
 # PYTEST_IGNORED_TESTS	- Lists of 'pytest -k' patterns to skip tests which are
 #			  not expected to pass, e.g. requiring a database access.
 #			  default: <empty>
 #
 # The following variables can be read by ports and must not be modified:
 #
 # PYTHONBASE		- The installation prefix of the chosen Python
 #			  interpreter, e.g. /usr/local
 #
 # PYTHON_DISTVERSION
 #			- Version number suitable for ${DISTVERSION}.
 #
 # PYTHON_PORTSDIR	- The port directory of the chosen Python interpreter
 #
 # PYTHON_REL		- The release number of the chosen Python interpreter
 #			  without dots, e.g. 20706, 30901, ...
 #
 # PYTHON_SUFFIX		- The major-minor release number of the chosen Python
 #			  interpreter without dots, e.g. 27, 38, ...
 #			  Used for prefixes and suffixes.
 #
 # PYTHON_MAJOR_VER	- The major release version of the chosen Python
 #			  interpreter, e.g. 2, 3, ...
 #
 # PYTHON_VER		- The major-minor release version of the chosen Python
 #			  interpreter, e.g. 2.7, 3.9, ...
 #
 # PYTHON_ABIVER		- Additional ABI flags set by the chosen Python
 #			  interpreter, e.g. md
 #
 # PYTHON_INCLUDEDIR	- Location of the Python include files.
 #			  default: ${PYTHONBASE}/include/${PYTHON_VERSION}
 #
 # PYTHON_LIBDIR		- Base of the python library tree
 #			  default: ${PYTHONBASE}/lib/${PYTHON_VERSION}
 #
 # PYTHON_SITELIBDIR	- Location of the site-packages tree. Don't change,
 #			  unless you know what you do.
 #			  default: ${PYTHON_LIBDIR}/site-packages
 #
 # There are PREFIX-clean variants of the PYTHON_*DIR variables above.
 # They are meant to be used by ports instead of the above variables, so the
 # ports respect ${PREFIX} (unless USE_PYTHON=pythonprefix is specified).
 #
 # PYTHONPREFIX_INCLUDEDIR	default: ${PREFIX}/include/${PYTHON_VERSION}
 # PYTHONPREFIX_LIBDIR		default: ${PREFIX}/lib/${PYTHON_VERSION}
 # PYTHONPREFIX_SITELIBDIR	default: ${PYTHONPREFIX_LIBDIR}/site-packages
 #
 # PYTHON_PLATFORM	- Python's idea of the OS release.
 #			  This is faked with ${OPSYS} and ${OSREL} until we
 #			  find out how to delay defining a variable until
 #			  after a certain target has been built.
 #
 # PYTHON_PKGNAMEPREFIX
 #			- Use this as a ${PKGNAMEPREFIX} to distinguish
 #			  packages for different Python versions.
 #			  default: py${PYTHON_SUFFIX}-
 #
 # PYTHON_PKGNAMESUFFIX
 #			- Use this as a ${PKGNAMESUFFIX} to distinguish
 #			  packages for different Python versions.
 #			  default: -py${PYTHON_SUFFIX}
 #
 # Using USES=python also will add some useful entries to SUB_LIST and PLIST_SUB:
 #
 #	PYTHON_INCLUDEDIR=${PYTHONPREFIX_INCLUDEDIR}
 #	PYTHON_LIBDIR=${PYTHONPREFIX_LIBDIR}
 #	PYTHON_PLATFORM=${PYTHON_PLATFORM}
 #	PYTHON_SITELIBDIR=${PYTHONPREFIX_SITELIBDIR}
 #	PYTHON_SUFFIX=${PYTHON_SUFFIX}
 #	PYTHON_VER=${PYTHON_VER}
 #	PYTHON_VERSION=${PYTHON_VERSION}
 #
 # where PYTHON_INCLUDEDIR, PYTHON_LIBDIR and PYTHON_SITELIBDIR have their PREFIX
 # stripped for PLIST_SUB.
 #
 # PYTHON2 and PYTHON3 will also be set according to the Python version:
 #
 #	PYTHON2="" PYTHON3="@comment " for Python 2.x
 #	PYTHON2="@comment " PYTHON3="" for Python 3.x
 #
 # PYDISTUTILS_INSTALLNOSINGLE
 #			- Deprecated without replacement
 #
 # Dependency lines of selected Python modules:
 #
 # PY_SETUPTOOLS			- setuptools port based on USE_PYTHON=distutils
 # PYGAME			- pygame port
 # PYNUMPY			- NumPy port
 # PY_MERCURIAL			- mercurial port, PKGNAME varies based on default
 #				  Python version
 # PY_BOOST			- Boost Python libraries port
 #
 # The following variables may be set by the user:
 #
 # PYTEST_ENABLE_ALL_TESTS	- Enable tests skipped by PYTEST_BROKEN_TESTS
 #				  and PYTEST_IGNORED_TESTS.
 # PYTEST_ENABLE_BROKEN_TESTS	- Enable tests skipped by PYTEST_BROKEN_TESTS.
 # PYTEST_ENABLE_IGNORED_TESTS	- Enable tests skipped by PYTEST_IGNORED_TESTS.
 #
 # MAINTAINER: python@FreeBSD.org
 
 .if !defined(_INCLUDE_USES_PYTHON_MK)
 _INCLUDE_USES_PYTHON_MK=	yes
 
 # What Python version and what Python interpreters are currently supported?
 # When adding a version, please keep the comment in
 # Mk/bsd.default-versions.mk in sync.
 _PYTHON_VERSIONS=		3.11 3.12 3.10 3.9 2.7 # preferred first
 _PYTHON_PORTBRANCH=		3.11		# ${_PYTHON_VERSIONS:[1]}
 _PYTHON_BASECMD=		${LOCALBASE}/bin/python
 _PYTHON_RELPORTDIR=		lang/python
 
 # List all valid USE_PYTHON features here
 _VALID_PYTHON_FEATURES=	allflavors \
 			autoplist \
 			concurrent \
 			cryptography_build \
 			cryptography \
 			cryptography_test \
 			cython \
 			cython_run \
 			cython_test \
+			cython3 \
+			cython3_run \
+			cython3_test \
 			distutils \
 			flavors \
 			noegginfo \
 			noflavors \
 			nose \
 			nose2 \
 			optsuffix \
 			pep517 \
 			py3kplist \
 			pytest \
 			pytest4 \
 			pythonprefix \
 			unittest \
 			unittest2
 _INVALID_PYTHON_FEATURES=
 .  for var in ${USE_PYTHON}
 .    if empty(_VALID_PYTHON_FEATURES:M${var})
 _INVALID_PYTHON_FEATURES+=	${var}
 .    endif
 .  endfor
 .  if !empty(_INVALID_PYTHON_FEATURES)
 IGNORE=	uses unknown USE_PYTHON features: ${_INVALID_PYTHON_FEATURES}
 .  endif
 
 # Make each individual feature available as _PYTHON_FEATURE_<FEATURENAME>
 .  for var in ${USE_PYTHON}
 _PYTHON_FEATURE_${var:C/=.*$//:tu}=	${var:C/.*=//:S/,/ /g}
 .  endfor
 .  if defined(_PYTHON_FEATURE_PYTEST) && defined(_PYTHON_FEATURE_PYTEST4)
 IGNORE=		uses either USE_PYTHON=pytest or USE_PYTHON=pytest4, not both of them
 .  endif
 
 # distutils automatically generates flavors depending on the supported
 # versions.
 .  if defined(_PYTHON_FEATURE_DISTUTILS)
 _PYTHON_FEATURE_FLAVORS=	yes
 .  endif
 
 # pep517 automatically generates flavors depending on the supported
 # versions.
 .  if defined(_PYTHON_FEATURE_PEP517)
 _PYTHON_FEATURE_FLAVORS=	yes
 .  endif
 
 .  if defined(_PYTHON_FEATURE_NOFLAVORS)
 .undef _PYTHON_FEATURE_FLAVORS
 .  endif
 
 # Make sure that no dependency or some other environment variable
 # pollutes the build/run dependency detection
 .undef _PYTHON_BUILD_DEP
 .undef _PYTHON_RUN_DEP
 .undef _PYTHON_TEST_DEP
 _PYTHON_ARGS=		${python_ARGS:S/,/ /g}
 .  if ${_PYTHON_ARGS:Mpatch}
 _PYTHON_PATCH_DEP=	yes
 _PYTHON_ARGS:=		${_PYTHON_ARGS:Npatch}
 .  endif
 .  if ${_PYTHON_ARGS:Mbuild}
 _PYTHON_BUILD_DEP=	yes
 _PYTHON_ARGS:=		${_PYTHON_ARGS:Nbuild}
 .  endif
 .  if ${_PYTHON_ARGS:Mrun}
 _PYTHON_RUN_DEP=	yes
 _PYTHON_ARGS:=		${_PYTHON_ARGS:Nrun}
 .  endif
 .  if ${_PYTHON_ARGS:Mtest}
 _PYTHON_TEST_DEP=	yes
 _PYTHON_ARGS:=		${_PYTHON_ARGS:Ntest}
 .  endif
 .  if ${_PYTHON_ARGS:Menv}
 PYTHON_NO_DEPENDS=	yes
 _PYTHON_ARGS:=		${_PYTHON_ARGS:Nenv}
 .  endif
 
 # The port does not specify a build, run or test dependency, assume all are
 # required.
 .  if !defined(_PYTHON_BUILD_DEP) && !defined(_PYTHON_RUN_DEP) && \
     !defined(_PYTHON_TEST_DEP) && !defined(PYTHON_NO_DEPENDS)
 _PYTHON_BUILD_DEP=	yes
 _PYTHON_RUN_DEP=	yes
 _PYTHON_TEST_DEP=	yes
 .  endif
 
 .  if ${_PYTHON_ARGS} == 2.7
 DEV_WARNING+=		"lang/python27 reached End of Life and will be removed somewhere in the future, please convert to a modern version of python"
 .  elif ${_PYTHON_ARGS} == 2
 DEV_ERROR+=		"USES=python:2 is no longer supported, use USES=python:2.7"
 .  elif ${_PYTHON_ARGS} == 3
 DEV_ERROR+=		"USES=python:3 is no longer supported, use USES=python:3.9+ or an appropriate version range"
 .  endif  # ${_PYTHON_ARGS} == 2.7
 
 _PYTHON_VERSION:=	${PYTHON_DEFAULT}
 
 .  if empty(_PYTHON_ARGS)
 _PYTHON_ARGS=	3.9+
 .  endif
 
 # Validate Python version whether it meets the version restriction.
 _PYTHON_VERSION_CHECK:=		${_PYTHON_ARGS:C/^([1-9]\.[1-9]?[0-9])$/\1-\1/}
 _PYTHON_VERSION_MINIMUM_TMP:=	${_PYTHON_VERSION_CHECK:C/([1-9]\.[1-9]?[0-9])[-+].*/\1/}
 _PYTHON_VERSION_MINIMUM:=	${_PYTHON_VERSION_MINIMUM_TMP:M[1-9].[0-9]}${_PYTHON_VERSION_MINIMUM_TMP:M[1-9].[1-9][0-9]}
 _PYTHON_VERSION_MAXIMUM_TMP:=	${_PYTHON_VERSION_CHECK:C/.*-([1-9]\.[1-9]?[0-9])/\1/}
 _PYTHON_VERSION_MAXIMUM:=	${_PYTHON_VERSION_MAXIMUM_TMP:M[1-9].[0-9]}${_PYTHON_VERSION_MAXIMUM_TMP:M[1-9].[1-9][0-9]}
 
 # At this point we should have no argument left in ${_PYTHON_ARGS}
 # except a version spec
 _V1=		[1-9].[0-9]
 _V2=		[1-9].[1-9][0-9]
 _PYTHON_ARGS:=	${_PYTHON_ARGS:N${_V1}-${_V1}:N${_V1}-${_V2}:N${_V2}-${_V2}:N${_V1}:N${_V2}:N${_V1}+:N${_V2}+:N-${_V1}:N-${_V2}}
 .  if !empty(_PYTHON_ARGS)
 IGNORE=	uses unknown USES=python arguments: ${_PYTHON_ARGS}
 .  endif
 
 # Pattern to convert python versions (X.Y or X.YY) to comparable format X.YY
 _VC=		C/^([1-9]\.)([0-9])$$/\10\2/
 
 .undef _PYTHON_VERSION_NONSUPPORTED
 .  if !empty(_PYTHON_VERSION_MINIMUM) && (${_PYTHON_VERSION:${_VC}} < ${_PYTHON_VERSION_MINIMUM:${_VC}})
 _PYTHON_VERSION_NONSUPPORTED=	${_PYTHON_VERSION_MINIMUM} at least
 .  elif !empty(_PYTHON_VERSION_MAXIMUM) && (${_PYTHON_VERSION:${_VC}} > ${_PYTHON_VERSION_MAXIMUM:${_VC}})
 _PYTHON_VERSION_NONSUPPORTED=	${_PYTHON_VERSION_MAXIMUM} at most
 .  endif
 
 # If we have an unsupported version of Python, try another.
 .  if defined(_PYTHON_VERSION_NONSUPPORTED)
 .undef _PYTHON_VERSION
 .    for ver in ${PYTHON_DEFAULT} ${PYTHON2_DEFAULT} ${_PYTHON_VERSIONS}
 __VER=		${ver}
 .      if !defined(_PYTHON_VERSION) && \
 	!(!empty(_PYTHON_VERSION_MINIMUM) && ( \
 		${__VER:${_VC}} < ${_PYTHON_VERSION_MINIMUM:${_VC}})) && \
 	!(!empty(_PYTHON_VERSION_MAXIMUM) && ( \
 		${__VER:${_VC}} > ${_PYTHON_VERSION_MAXIMUM:${_VC}}))
 _PYTHON_VERSION=	${ver}
 .      endif
 .    endfor
 .    if !defined(_PYTHON_VERSION)
 IGNORE=		needs an unsupported version of Python
 .    endif
 .  endif	# defined(_PYTHON_VERSION_NONSUPPORTED)
 
 # Automatically generates FLAVORS if empty
 .  if empty(FLAVORS) && defined(_PYTHON_FEATURE_FLAVORS)
 .  undef _VALID_PYTHON_VERSIONS
 .    for ver in ${PYTHON_DEFAULT} ${PYTHON2_DEFAULT} ${_PYTHON_VERSIONS}
 __VER=		${ver}
 .      if !(!empty(_PYTHON_VERSION_MINIMUM) && ( \
 		${__VER:${_VC}} < ${_PYTHON_VERSION_MINIMUM:${_VC}})) && \
 	!(!empty(_PYTHON_VERSION_MAXIMUM) && ( \
 		${__VER:${_VC}} > ${_PYTHON_VERSION_MAXIMUM:${_VC}}))
 .        if empty(_VALID_PYTHON_VERSIONS:M${ver})
 _VALID_PYTHON_VERSIONS+=	${ver}
 .        endif
 .      endif
 .    endfor
 # Get all possible flavors depending on version requirements
 .    if defined(_VALID_PYTHON_VERSIONS)
 _ALL_PYTHON_FLAVORS=	${_VALID_PYTHON_VERSIONS:S/.//:S/^/py/}
 .    else
 _ALL_PYTHON_FLAVORS=	${_PYTHON_VERSIONS:S/.//:S/^/py/}
 .    endif
 # Decide how many flavors we want.  By default, only generate the default
 # versions.
 .    if defined(BUILD_ALL_PYTHON_FLAVORS) || defined(_PYTHON_FEATURE_ALLFLAVORS)
 FLAVORS=	${_ALL_PYTHON_FLAVORS}
 .    else
 .      for _v in ${PYTHON_DEFAULT} ${PYTHON2_DEFAULT}
 _f=	py${_v:S/.//}
 .        if ${_ALL_PYTHON_FLAVORS:M${_f}} && !${FLAVORS:M${_f}}
 .          if !empty(FLAVORS)
 FLAVORS:=	${FLAVORS} ${_f}
 .          else
 FLAVORS:=	${_f}
 .          endif
 .        endif
 .      endfor
 .    endif
 .    if !empty(FLAVORS) && empty(FLAVOR)
 FLAVOR=	${FLAVORS:[1]}
 .    endif
 .  endif
 
 .  if ${FLAVOR:Mpy[23][0-9]}${FLAVOR:Mpy[23][1-9][0-9]}
 _PYTHON_VERSION=	${FLAVOR:S/py//:C/(.)/\1./}
 .  endif
 
 .  if !empty(FLAVOR) && ${_PYTHON_VERSION} != ${PYTHON_DEFAULT}
 .    if defined(_PYTHON_FEATURE_OPTSUFFIX)
 DEV_WARNING+=	"USE_PYTHON=optsuffix is deprecated, consider migrating to using unconditional PKGNAMESUFFIX or PKGNAMEPREFIX"
 PKGNAMESUFFIX=	${PYTHON_PKGNAMESUFFIX}
 .    endif
 .  endif
 
 # To avoid having dependencies with @ and empty flavor:
 # _PYTHON_VERSION is either set by (first that matches):
 # - If using Python flavors, from the current Python flavor
 # - If using a version restriction (USES=python:3.9+), from the first
 #   acceptable default Python version.
 # - From PYTHON_DEFAULT
 PY_FLAVOR=	py${_PYTHON_VERSION:S/.//}
 
 PYTHON_VERSION=	python${_PYTHON_VERSION}
 
 # Got the correct python version, set some publicly accessible variables
 PYTHON_VER=		${_PYTHON_VERSION}
 PYTHON_SUFFIX=		${_PYTHON_VERSION:S/.//g}
 PYTHON_MAJOR_VER=	${PYTHON_VER:R}
 PYTHON_REL=		# empty
 PYTHON_ABIVER=		# empty
 PYTHON_PORTSDIR=	${_PYTHON_RELPORTDIR}${PYTHON_SUFFIX}
 
 # Protect partial checkouts from Mk/Scripts/functions.sh:export_ports_env().
 .  if !defined(_PORTS_ENV_CHECK) || exists(${PORTSDIR}/${PYTHON_PORTSDIR})
 .include "${PORTSDIR}/${PYTHON_PORTSDIR}/Makefile.version"
 .  endif
 # Create a 5 integer version string, prefixing 0 to the minor and patch
 # tokens if it's a single character. Only use the first 3 tokens of
 # PORTVERSION to support pre-release versions (rc3, alpha4, etc) of
 # any Python port (lang/pythonXY)
 PYTHON_REL=	${PYTHON_DISTVERSION:C/^([0-9]+\.[0-9]+\.[0-9]+).*/\1/:C/\.([0-9])$/.0\1/:C/\.([0-9]\.[0-9]+)/.0\1/:S/.//g}
 
 # Might be overridden by calling ports
 PYTHON_CMD?=		${_PYTHON_BASECMD}${_PYTHON_VERSION}
 .  if ${PYTHON_MAJOR_VER} > 2
 .    if exists(${PYTHON_CMD}-config)
 PYTHON_ABIVER!=		${PYTHON_CMD}-config --abiflags
 .    endif
 .  endif
 
 .  if ${PYTHON_REL} >= 30807
 PYTHON_EXT_SUFFIX=	.cpython-${PYTHON_SUFFIX}
 .  else
 PYTHON_EXT_SUFFIX=	# empty
 .  endif
 
 .  if ${PYTHON_MAJOR_VER} < 3
 DEPRECATED?=	Uses Python 2.7 which is EOLed upstream
 .  endif
 
 .  if !defined(PYTHONBASE)
 PYTHONBASE!=	(${PYTHON_CMD} -c 'import sys; print(sys.prefix)' \
 			2> /dev/null || ${ECHO_CMD} ${LOCALBASE}) | ${TAIL} -1
 .  endif
 _EXPORTED_VARS+=	PYTHONBASE
 
 PYTHON_INCLUDEDIR=	${PYTHONBASE}/include/python${_PYTHON_VERSION}${PYTHON_ABIVER}
 PYTHON_LIBDIR=		${PYTHONBASE}/lib/python${_PYTHON_VERSION}
 PYTHON_PLATFORM=	${OPSYS:tl}${OSREL:C/\.[0-9.]*//}
 PYTHON_SITELIBDIR=	${PYTHON_LIBDIR}/site-packages
 PYTHON_PKGNAMEPREFIX=	py${PYTHON_SUFFIX}-
 PYTHON_PKGNAMESUFFIX=	-py${PYTHON_SUFFIX}
 
 PYTHONPREFIX_INCLUDEDIR=	${PYTHON_INCLUDEDIR:S;${PYTHONBASE};${PREFIX};}
 PYTHONPREFIX_LIBDIR=		${PYTHON_LIBDIR:S;${PYTHONBASE};${PREFIX};}
 PYTHONPREFIX_SITELIBDIR=	${PYTHON_SITELIBDIR:S;${PYTHONBASE};${PREFIX};}
 
 # Used for recording the installed files.
 _PYTHONPKGLIST=	${WRKDIR}/.PLIST.pymodtmp
 
 # Ports bound to a certain python version SHOULD
 # - use the PYTHON_PKGNAMEPREFIX
 # - use directories using the PYTHON_PKGNAMEPREFIX
 # - install binaries using the required PYTHON_VER, with
 #   the default python version creating a symlink to the original binary
 #   name (for staging-aware ports).
 #
 # What makes a port 'bound' to a certain python version?
 # - it installs data into PYTHON_SITELIBDIR, PYTHON_INCLUDEDIR, ...
 # - it links against libpython*.so
 # - it uses USE_PYTHON=distutils
 #
 
 # cryptography* support
 .  if ${PYCRYPTOGRAPHY_DEFAULT} == rust
 CRYPTOGRAPHY_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cryptography>=42.0.8,1:security/py-cryptography@${PY_FLAVOR}
 .  else
 CRYPTOGRAPHY_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cryptography-legacy>=3.4.8_1,1:security/py-cryptography-legacy@${PY_FLAVOR}
 .  endif
 
 .  if defined(_PYTHON_FEATURE_CRYPTOGRAPHY_BUILD)
 BUILD_DEPENDS+=	${CRYPTOGRAPHY_DEPENDS}
 .  endif
 
 .  if defined(_PYTHON_FEATURE_CRYPTOGRAPHY)
 RUN_DEPENDS+=	${CRYPTOGRAPHY_DEPENDS}
 .  endif
 
 .  if defined(_PYTHON_FEATURE_CRYPTOGRAPHY_TEST)
 TEST_DEPENDS+=	${CRYPTOGRAPHY_DEPENDS}
 .  endif
 
 # cython* support
+
 .  if defined(_PYTHON_FEATURE_CYTHON)
-BUILD_DEPENDS+=	cython-${PYTHON_VER}:lang/cython@${PY_FLAVOR}
+BUILD_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}cython>=0.29.37<3:lang/cython@${PY_FLAVOR}
 .  endif
 
 .  if defined(_PYTHON_FEATURE_CYTHON_RUN)
-RUN_DEPENDS+=	cython-${PYTHON_VER}:lang/cython@${PY_FLAVOR}
+RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}cython>=0.29.37<3:lang/cython@${PY_FLAVOR}
 .  endif
 
 .  if defined(_PYTHON_FEATURE_CYTHON_TEST)
-TEST_DEPENDS+=	cython-${PYTHON_VER}:lang/cython@${PY_FLAVOR}
+TEST_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}cython>=0.29.37<3:lang/cython@${PY_FLAVOR}
+.  endif
+
+.  if defined(_PYTHON_FEATURE_CYTHON3)
+BUILD_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}cython3>=3.0.12<3.1:lang/cython3@${PY_FLAVOR}
+.  endif
+
+.  if defined(_PYTHON_FEATURE_CYTHON3_RUN)
+RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}cython3>=3.0.12<3.1:lang/cython3@${PY_FLAVOR}
+.  endif
+
+.  if defined(_PYTHON_FEATURE_CYTHON3_TEST)
+TEST_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}cython3>=3.0.12<3.1:lang/cython3@${PY_FLAVOR}
 .  endif
 
 .  if defined(_PYTHON_FEATURE_CONCURRENT)
 .    if !defined(_PYTHON_FEATURE_FLAVORS) && (${_PYTHON_VERSION_MINIMUM:M3*} || ${_PYTHON_VERSION_MAXIMUM:M2*})
 DEV_WARNING+=	"USE_PYTHON=concurrent when only one of Python 2 or 3 is supported AND not using flavors does not make any sense"
 .    endif
 _USES_POST+=		uniquefiles:dirs
 .    if defined(_PYTHON_FEATURE_FLAVORS) && ${FLAVOR} == ${FLAVORS:[1]}
 UNIQUE_DEFAULT_LINKS=	yes
 .    elif !defined(_PYTHON_FEATURE_FLAVORS) && ${_PYTHON_VERSION} == ${PYTHON_DEFAULT}
 UNIQUE_DEFAULT_LINKS=	yes
 .    else
 UNIQUE_DEFAULT_LINKS=	no
 .    endif
 UNIQUE_PREFIX=		${PYTHON_PKGNAMEPREFIX}
 UNIQUE_SUFFIX=		-${PYTHON_VER}
 UNIQUE_SUFFIX_TYPES+=	SUFFIX_MAN
 UNIQUE_SUFFIX_MAN_WITH_EXT=	.[1-9ln]
 UNIQUE_SUFFIX_MAN_EXTRA_EXT=	.gz
 
 .    if defined(_PYTHON_FEATURE_AUTOPLIST)
 _UNIQUE_FIND_SUFFIX_FILES=	${SED} -e 's|^${PREFIX}/||' ${_PYTHONPKGLIST} ${TMPPLIST}
 .    else
 _UNIQUE_FIND_SUFFIX_FILES=	${SED} -e 's|^${PREFIX}/||' ${TMPPLIST} 2>/dev/null
 .    endif
 UNIQUE_FIND_SUFFIX_FILES+=	${_UNIQUE_FIND_SUFFIX_FILES} | \
 				${EGREP} -he '^bin/.*$$|^sbin/.*$$|^libexec/.*$$'
 UNIQUE_FIND_SUFFIX_MAN_FILES+=	${_UNIQUE_FIND_SUFFIX_FILES} | \
 				${EGREP} -he '^man/man[1-9ln]/.*$$|^share/man/man[1-9ln]/.*$$'
 .  endif # defined(_PYTHON_FEATURE_CONCURRENT)
 
 _CURRENTPORT:=	${PKGNAMEPREFIX}${PORTNAME}${PKGNAMESUFFIX}
 .  if defined(_PYTHON_FEATURE_DISTUTILS) && \
 	${_CURRENTPORT} != ${PYTHON_PKGNAMEPREFIX}setuptools && \
 	${_CURRENTPORT} != ${PYTHON_PKGNAMEPREFIX}setuptools58 && \
 	${_CURRENTPORT} != ${PYTHON_PKGNAMEPREFIX}setuptools44
 .    if ${PYTHON_VER} == 2.7
 BUILD_DEPENDS+=		${PYTHON_PKGNAMEPREFIX}setuptools44>0:devel/py-setuptools44@${PY_FLAVOR}
 RUN_DEPENDS+=		${PYTHON_PKGNAMEPREFIX}setuptools44>0:devel/py-setuptools44@${PY_FLAVOR}
 .    else
 BUILD_DEPENDS+=		${PYTHON_PKGNAMEPREFIX}setuptools>=63.1.0:devel/py-setuptools@${PY_FLAVOR}
 .    endif
 .  endif
 
 .  if defined(_PYTHON_FEATURE_PEP517)
 .    if ${PYTHON_MAJOR_VER} < 3
 DEV_ERROR+=		"USES=python:2.7 is incompatible with USE_PYTHON=pep517"
 .    endif
 .    if defined(_PYTHON_FEATURE_DISTUTILS)
 DEV_ERROR+=		"USE_PYTHON=distutils is incompatible with USE_PYTHON=pep517"
 .    endif
 .    if defined(_PYTHON_FEATURE_PY3KPLIST)
 DEV_ERROR+=		"USE_PYTHON=py3kplist is incompatible with USE_PYTHON=pep517"
 .    endif
 .    if defined(_PYTHON_FEATURE_NOEGGINFO)
 DEV_ERROR+=		"USE_PYTHON=noegginfo is incompatible with USE_PYTHON=pep517"
 .    endif
 .  endif
 
 # distutils support
 PYSETUP?=		setup.py
 PYDISTUTILS_SETUP?=	-c \
 	"import sys; import setuptools; \
 	__file__='${PYSETUP}'; sys.argv[0]='${PYSETUP}'; \
 	exec(compile(open(__file__, 'rb').read().replace(b'\\r\\n', b'\\n'), __file__, 'exec'))"
 PYDISTUTILS_CONFIGUREARGS?=	# empty
 PYDISTUTILS_BUILDARGS?=		# empty
 PYDISTUTILS_INSTALLARGS?=	-c -O1 --prefix=${PREFIX}
 .  if defined(_PYTHON_FEATURE_DISTUTILS)
 .    if !defined(PYDISTUTILS_INSTALLNOSINGLE)
 PYDISTUTILS_INSTALLARGS+=	--single-version-externally-managed
 .    endif
 PYDISTUTILS_INSTALLARGS+=	--root=${STAGEDIR}
 .  endif
 PYDISTUTILS_INSTALLARGS:=	--record ${_PYTHONPKGLIST} \
 		${PYDISTUTILS_INSTALLARGS}
 
 PYDISTUTILS_PKGNAME?=	${PORTNAME}
 PYDISTUTILS_PKGVERSION?=${PORTVERSION}
 PYDISTUTILS_EGGINFO?=	${PYDISTUTILS_PKGNAME:C/[^A-Za-z0-9.]+/_/g}-${PYDISTUTILS_PKGVERSION:C/[^A-Za-z0-9.]+/_/g}-py${PYTHON_VER}.egg-info
 PYDISTUTILS_EGGINFODIR?=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 # PEP-517 support
 PEP517_BUILD_CMD?=	${PYTHON_CMD} -m build --no-isolation --wheel ${PEP517_BUILD_CONFIG_SETTING}
 PEP517_BUILD_DEPEND?=	${PYTHON_PKGNAMEPREFIX}build>=0:devel/py-build@${PY_FLAVOR}
 PEP517_INSTALL_CMD?=	${PYTHON_CMD} -m installer --destdir ${STAGEDIR} --prefix ${PREFIX} ${BUILD_WRKSRC}/dist/${PORTNAME:C|[-_]+|_|g}-${DISTVERSION}*.whl
 PEP517_INSTALL_DEPEND?=	${PYTHON_PKGNAMEPREFIX}installer>=0:devel/py-installer@${PY_FLAVOR}
 
 # nose support
 .  if defined(_PYTHON_FEATURE_NOSE)
 TEST_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}nose>=0:devel/py-nose@${PY_FLAVOR}
 .  endif
 
 # nose2 support
 .  if defined(_PYTHON_FEATURE_NOSE2)
 TEST_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}nose2>=0:devel/py-nose2@${PY_FLAVOR}
 .  endif
 
 # pytest support
 .  if defined(_PYTHON_FEATURE_PYTEST)
 TEST_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}pytest>=7,1:devel/py-pytest@${PY_FLAVOR}
 .  elif defined(_PYTHON_FEATURE_PYTEST4)
 TEST_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}pytest4>=4.6,1:devel/py-pytest4@${PY_FLAVOR}
 .  endif
 .  if defined(_PYTHON_FEATURE_PYTEST) || defined(_PYTHON_FEATURE_PYTEST4)
 PYTEST_BROKEN_TESTS?=	# empty
 PYTEST_IGNORED_TESTS?=	# empty
 _PYTEST_SKIPPED_TESTS?=	# empty
 .    if !defined(PYTEST_ENABLE_ALL_TESTS)
 .      if !defined(PYTEST_ENABLE_BROKEN_TESTS)
 _PYTEST_SKIPPED_TESTS+=	${PYTEST_BROKEN_TESTS}
 .      endif
 .      if !defined(PYTEST_ENABLE_IGNORED_TESTS)
 _PYTEST_SKIPPED_TESTS+=	${PYTEST_IGNORED_TESTS}
 .      endif
 .    endif # !defined(PYTEST_ENABLE_ALL_TESTS)
 _PYTEST_FILTER_EXPRESSION=	${_PYTEST_SKIPPED_TESTS:C/^(.)/and not \1/:tW:C/^and //}
 .  endif # defined(_PYTHON_FEATURE_PYTEST) || defined(_PYTHON_FEATURE_PYTEST4)
 
 # unittest2 support
 .  if defined(_PYTHON_FEATURE_UNITTEST2)
 TEST_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}unittest2>=0:devel/py-unittest2@${PY_FLAVOR}
 .  endif
 
 .  if !defined(_PYTHON_FEATURE_NOEGGINFO) && \
 	!defined(_PYTHON_FEATURE_AUTOPLIST) && \
 	defined(_PYTHON_FEATURE_DISTUTILS) && \
 	defined(PYTHON_REL)
 _USES_stage+=	933:add-plist-egginfo
 add-plist-egginfo:
 .    for egginfo in ${PYDISTUTILS_EGGINFO}
 	if [ -d "${PYDISTUTILS_EGGINFODIR}/${egginfo}" ]; then \
 		${LS} ${PYDISTUTILS_EGGINFODIR}/${egginfo} | while read f; do \
 			${ECHO_CMD} ${PYDISTUTILS_EGGINFODIR:S;^${STAGEDIR}${PREFIX}/;;}/${egginfo}/$${f} >> ${TMPPLIST}; \
 		done; \
 	fi;
 .    endfor
 .  endif
 
 .  if defined(_PYTHON_FEATURE_AUTOPLIST) && (defined(_PYTHON_FEATURE_DISTUTILS) || defined(_PYTHON_FEATURE_PEP517))
 _RELSITELIBDIR=	${PYTHONPREFIX_SITELIBDIR:S;${PREFIX}/;;}
 _RELLIBDIR=		${PYTHONPREFIX_LIBDIR:S;${PREFIX}/;;}
 
 _USES_stage+=	934:add-plist-pymod
 add-plist-pymod:
 	@${SED} -e 's|^"\(.*\)"$$|\1|' \
 		-e 's|^${STAGEDIR}${PREFIX}/||' \
 		-e 's|^${PREFIX}/||' \
 		-e 's|^\(man/.*man[0-9]\)/\(.*\.[0-9]\)$$|\1/\2.gz|' \
 		-e 's|^\(share/man/.*man[0-9]\)/\(.*\.[0-9]\)$$|\1/\2.gz|' \
 		-e 's|[[:alnum:]|[:space:]]*/\.\./*||g; s|/\./|/|g' \
 		${_PYTHONPKGLIST} | ${SORT} >> ${TMPPLIST}
 
 .  else
 .    if ${PYTHON_REL} >= 30200 && defined(_PYTHON_FEATURE_PY3KPLIST)
 # When Python version is 3.2+ we rewrite all the filenames
 # of TMPPLIST that end with .py[co], so that they conform
 # to PEP 3147 (see https://www.python.org/dev/peps/pep-3147/)
 PYMAGICTAG=		${PYTHON_CMD} -c 'import sys; print(sys.implementation.cache_tag)'
 _USES_stage+=	935:add-plist-python
 add-plist-python:
 	@${AWK} '\
 		/\.py[co]$$/ && !($$0 ~ "/" pc "/") {id = match($$0, /\/[^\/]+\.py[co]$$/); if (id != 0) {d = substr($$0, 1, RSTART - 1); dirs[d] = 1}; sub(/\.pyc$$/,  "." mt "&"); sub(/\.pyo$$/, "." mt "." pyo); sub(/[^\/]+\.py[co]$$/, pc "/&"); print; next} \
 		/^@dirrm / {d = substr($$0, 8); if (d in dirs) {print $$0 "/" pc}; print $$0; next} \
 		/^@dirrmtry / {d = substr($$0, 11); if (d in dirs) {print $$0 "/" pc}; print $$0; next} \
 		{print} \
 		' \
 		pc="__pycache__" mt="$$(${PYMAGICTAG})" pyo="opt-1.pyc" \
 		${TMPPLIST} > ${TMPPLIST}.pyc_tmp
 	@${MV} ${TMPPLIST}.pyc_tmp ${TMPPLIST}
 .    endif # ${PYTHON_REL} >= 30200 && defined(_PYTHON_FEATURE_PY3KPLIST)
 .  endif # defined(_PYTHON_FEATURE_AUTOPLIST) && (defined(_PYTHON_FEATURE_DISTUTILS) || defined(_PYTHON_FEATURE_PEP517))
 
 # Fix for programs that build python from a GNU auto* environment
 CONFIGURE_ENV+=	PYTHON="${PYTHON_CMD}"
 
 # By default CMake picks up the highest available version of Python package.
 # Enforce the version required by the port or the default.
 CMAKE_ARGS+=	-DPython_ADDITIONAL_VERSIONS=${PYTHON_VER}
 CMAKE_ARGS+=	-DPython_EXECUTABLE:FILEPATH="${PYTHON_CMD}"
 CMAKE_ARGS+=	-DPython${PYTHON_MAJOR_VER}_EXECUTABLE:FILEPATH="${PYTHON_CMD}"
 
 # Python 3rd-party modules
 PYGAME=		${PYTHON_PKGNAMEPREFIX}game>0:devel/py-game@${PY_FLAVOR}
 PYNUMPY=	${PYTHON_PKGNAMEPREFIX}numpy>=1.16,1<1.27,1:math/py-numpy@${PY_FLAVOR}
 
 .  if defined(_PYTHON_FEATURE_DISTUTILS)
 .    if ${PYTHON_MAJOR_VER} < 3
 PY_SETUPTOOLS=	${PYTHON_PKGNAMEPREFIX}setuptools44>0:devel/py-setuptools44@${PY_FLAVOR}
 .    else
 #PY_SETUPTOOLS=	${PYTHON_PKGNAMEPREFIX}setuptools58>0:devel/py-setuptools58@${PY_FLAVOR}
 PY_SETUPTOOLS=	${PYTHON_PKGNAMEPREFIX}setuptools>0:devel/py-setuptools@${PY_FLAVOR}
 .    endif
 .  else
 PY_SETUPTOOLS=	${PYTHON_PKGNAMEPREFIX}setuptools>0:devel/py-setuptools@${PY_FLAVOR}
 .  endif
 
 # Common Python modules that can be needed but only for some versions of Python.
 .  if ${PYTHON_REL} < 31100
 PY_EXCEPTIONGROUP=	${PYTHON_PKGNAMEPREFIX}exceptiongroup>=1.1.1:devel/py-exceptiongroup@${PY_FLAVOR}
 PY_TOMLI=	${PYTHON_PKGNAMEPREFIX}tomli>=2.0.2<3:textproc/py-tomli@${PY_FLAVOR}
 .  endif
 
 .  if ${PYTHON_REL} >= 30000
 PY_PILLOW=	${PYTHON_PKGNAMEPREFIX}pillow>=7.0.0:graphics/py-pillow@${PY_FLAVOR}
 .  endif
 
 .  if ${PYTHON_VER} != ${PYTHON_DEFAULT}
 PY_MERCURIAL=	${PYTHON_PKGNAMEPREFIX}mercurial>=5.9:devel/mercurial@${PY_FLAVOR}
 .  else
 PY_MERCURIAL=	mercurial>=5.9:devel/mercurial@${PY_FLAVOR}
 .  endif
 
 CMAKE_ARGS+=	-DBOOST_PYTHON_SUFFIX:STRING=${PYTHON_SUFFIX}
 PY_BOOST_LIB=	boost_python${PYTHON_SUFFIX}
 PY_BOOST=	lib${PY_BOOST_LIB}.so:devel/boost-python-libs@${PY_FLAVOR}
 
 # dependencies
 .  for _stage in PATCH BUILD RUN TEST
 .    if defined(_PYTHON_${_stage}_DEP)
 ${_stage}_DEPENDS+=	${PYTHON_CMD}:${PYTHON_PORTSDIR}
 .    endif
 .  endfor
 
 # set $PREFIX as Python's one
 .  if defined(_PYTHON_FEATURE_PYTHONPREFIX)
 PREFIX=		${PYTHONBASE}
 .  endif
 
 # Substitutions for SUB_FILES
 SUB_LIST+=	PYTHON_INCLUDEDIR=${PYTHONPREFIX_INCLUDEDIR} \
 		PYTHON_LIBDIR=${PYTHONPREFIX_LIBDIR} \
 		PYTHON_PLATFORM=${PYTHON_PLATFORM} \
 		PYTHON_SITELIBDIR=${PYTHONPREFIX_SITELIBDIR} \
 		PYTHON_SUFFIX=${PYTHON_SUFFIX} \
 		PYTHON_EXT_SUFFIX=${PYTHON_EXT_SUFFIX} \
 		PYTHON_VER=${PYTHON_VER} \
 		PYTHON_VERSION=${PYTHON_VERSION}
 
 # Substitutions for pkg-plist
 # Use a short form of the PYTHONPREFIX_*DIR variables; we don't need the
 # base directory in the plist file.
 PLIST_SUB+=	PYTHON_INCLUDEDIR=${PYTHONPREFIX_INCLUDEDIR:S;${PREFIX}/;;} \
 		PYTHON_LIBDIR=${PYTHONPREFIX_LIBDIR:S;${PREFIX}/;;} \
 		PYTHON_PLATFORM=${PYTHON_PLATFORM} \
 		PYTHON_SITELIBDIR=${PYTHONPREFIX_SITELIBDIR:S;${PREFIX}/;;} \
 		PYTHON_SUFFIX=${PYTHON_SUFFIX} \
 		PYTHON_EXT_SUFFIX=${PYTHON_EXT_SUFFIX} \
 		PYTHON_VER=${PYTHON_VER} \
 		PYTHON_VERSION=${PYTHON_VERSION}
 .  if ${PYTHON_MAJOR_VER} < 3
 SUB_LIST+=	PYTHON2="" PYTHON3="@comment "
 PLIST_SUB+=	PYTHON2="" PYTHON3="@comment "
 .  else
 SUB_LIST+=	PYTHON2="@comment " PYTHON3=""
 PLIST_SUB+=	PYTHON2="@comment " PYTHON3=""
 .  endif
 
 _USES_POST+=	python
 .endif # _INCLUDE_USES_PYTHON_MK
 
 .if defined(_POSTMKINCLUDED) && !defined(_INCLUDE_USES_PYTHON_POST_MK)
 _INCLUDE_USES_PYTHON_POST_MK=	yes
 
 # py-distutils support
 PYDISTUTILS_CONFIGURE_TARGET?=	config
 PYDISTUTILS_BUILD_TARGET?=	build
 PYDISTUTILS_INSTALL_TARGET?=	install
 
 .  if defined(_PYTHON_FEATURE_DISTUTILS)
 LDSHARED?=	${CC} -shared
 MAKE_ENV+=	LDSHARED="${LDSHARED}" PYTHONDONTWRITEBYTECODE= PYTHONOPTIMIZE=
 
 .    if !target(do-configure) && !defined(HAS_CONFIGURE) && !defined(GNU_CONFIGURE)
 do-configure:
 	@(cd ${BUILD_WRKSRC}; ${SETENVI} ${WRK_ENV} ${MAKE_ENV} ${PYTHON_CMD} ${PYDISTUTILS_SETUP} ${PYDISTUTILS_CONFIGURE_TARGET} ${PYDISTUTILS_CONFIGUREARGS})
 .    endif
 
 .    if !target(do-build)
 do-build:
 	@(cd ${BUILD_WRKSRC}; ${SETENVI} ${WRK_ENV} ${MAKE_ENV} ${PYTHON_CMD} ${PYDISTUTILS_SETUP} ${PYDISTUTILS_BUILD_TARGET} ${PYDISTUTILS_BUILDARGS})
 .    endif
 
 .    if !target(do-install)
 do-install:
 	@(cd ${INSTALL_WRKSRC}; ${SETENVI} ${WRK_ENV} ${MAKE_ENV} ${PYTHON_CMD} ${PYDISTUTILS_SETUP} ${PYDISTUTILS_INSTALL_TARGET} ${PYDISTUTILS_INSTALLARGS})
 .    endif
 .  endif # defined(_PYTHON_FEATURE_DISTUTILS)
 
 .  if defined(_PYTHON_FEATURE_PEP517)
 .    if !empty(PEP517_BUILD_DEPEND)
 BUILD_DEPENDS+=	${PEP517_BUILD_DEPEND}
 .    endif
 .    if !empty(PEP517_INSTALL_DEPEND)
 BUILD_DEPENDS+=	${PEP517_INSTALL_DEPEND}
 .    endif
 
 .    if !target(do-configure) && !defined(HAS_CONFIGURE) && !defined(GNU_CONFIGURE)
 do-configure:
 	@${DO_NADA}
 .    endif
 
 .    if !target(do-build)
 do-build:
 	@cd ${BUILD_WRKSRC} && ${SETENVI} ${WRK_ENV} ${MAKE_ENV} ${PEP517_BUILD_CMD}
 .    endif
 
 .    if !target(do-install)
 do-install:
 	@${MKDIR} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 	@cd ${INSTALL_WRKSRC} && ${SETENVI} ${WRK_ENV} ${MAKE_ENV} ${PEP517_INSTALL_CMD}
 	@${PYTHON_CMD} -B ${PORTSDIR}/Mk/Scripts/strip_RECORD.py \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/${PORTNAME:C|[-_]+|_|g}-${DISTVERSION}*.dist-info/RECORD >> ${_PYTHONPKGLIST}
 	@${REINPLACE_CMD} \
 		-e '/\.pyc$$/d' \
 		-e 's|^|${PYTHONPREFIX_SITELIBDIR}/|' \
 		-e 's|^${PYTHONPREFIX_SITELIBDIR}/../../../etc/|etc/|' \
 		-e 's|^${PYTHONPREFIX_SITELIBDIR}/../../../bin/|bin/|' \
 		-e 's|^${PYTHONPREFIX_SITELIBDIR}/../../../include/|include/|' \
 		-e 's|^${PYTHONPREFIX_SITELIBDIR}/../../../lib/|lib/|' \
 		-e 's|^${PYTHONPREFIX_SITELIBDIR}/../../../libdata/|libdata/|' \
 		-e 's|^${PYTHONPREFIX_SITELIBDIR}/../../../libexec/|libexec/|' \
 		-e 's|^${PYTHONPREFIX_SITELIBDIR}/../../../man/|man/|' \
 		-e 's|^${PYTHONPREFIX_SITELIBDIR}/../../../sbin/|sbin/|' \
 		-e 's|^${PYTHONPREFIX_SITELIBDIR}/../../../share/|share/|' \
 			${_PYTHONPKGLIST}
 	@cd ${STAGEDIR}${PREFIX} && ${FIND} lib -name '*.pyc' >> ${_PYTHONPKGLIST}
 .    endif
 .  endif # defined(_PYTHON_FEATURE_PEP517)
 
 .  if defined(_PYTHON_FEATURE_NOSE)
 .    if !target(do-test)
 do-test:
 	cd ${TEST_WRKSRC} && ${SETENVI} ${WRK_ENV} ${TEST_ENV} ${PYTHON_CMD} -m nose ${TEST_ARGS:NDESTDIR=*} -v
 .    endif
 .  endif # defined(_PYTHON_FEATURE_NOSE)
 
 .  if defined(_PYTHON_FEATURE_NOSE2)
 .    if !target(do-test)
 do-test:
 	cd ${TEST_WRKSRC} && ${SETENVI} ${WRK_ENV} ${TEST_ENV} ${PYTHON_CMD} -m nose2 ${TEST_ARGS:NDESTDIR=*} -v
 .    endif
 .  endif # defined(_PYTHON_FEATURE_NOSE2)
 
 .  if defined(_PYTHON_FEATURE_PYTEST) || defined(_PYTHON_FEATURE_PYTEST4)
 .    if !target(do-test)
 do-test:
 	cd ${TEST_WRKSRC} && ${SETENVI} ${WRK_ENV} ${TEST_ENV} ${PYTHON_CMD} -m pytest -k '${_PYTEST_FILTER_EXPRESSION}' -rs -v -o addopts= ${TEST_ARGS:NDESTDIR=*}
 .    endif
 .  endif # defined(_PYTHON_FEATURE_PYTEST) || defined(_PYTHON_FEATURE_PYTEST4)
 
 .  if defined(_PYTHON_FEATURE_UNITTEST)
 .    if !target(do-test)
 do-test:
 	cd ${TEST_WRKSRC} && ${SETENVI} ${WRK_ENV} ${TEST_ENV} ${PYTHON_CMD} -m unittest ${TEST_ARGS:NDESTDIR=*} -v
 .    endif
 .  endif # defined(_PYTHON_FEATURE_UNITTEST)
 
 .  if defined(_PYTHON_FEATURE_UNITTEST2)
 .    if !target(do-test)
 do-test:
 	cd ${TEST_WRKSRC} && ${SETENVI} ${WRK_ENV} ${TEST_ENV} ${PYTHON_CMD} -m unittest2 ${TEST_ARGS:NDESTDIR=*} -v
 .    endif
 .  endif # defined(_PYTHON_FEATURE_UNITTEST2)
 
 .endif # defined(_POSTMKINCLUDED) && !defined(_INCLUDE_USES_PYTHON_POST_MK)
diff --git a/astro/py-astropy/Makefile b/astro/py-astropy/Makefile
index 8f4f05db21cd..ebcf0705b801 100644
--- a/astro/py-astropy/Makefile
+++ b/astro/py-astropy/Makefile
@@ -1,28 +1,27 @@
 PORTNAME=	astropy
 DISTVERSION=	7.0.1
 PORTREVISION=	1
 PORTEPOCH=	2
 CATEGORIES=	astro
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	wen@FreeBSD.org
 COMMENT=	Community-developed python astronomy tools
 WWW=		https://www.astropy.org/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.rst
 
 BUILD_DEPENDS=	${PYNUMPY} \
-		${PYTHON_PKGNAMEPREFIX}cython3>=3.0:lang/cython3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}extension-helpers>=0:astro/py-extension-helpers@${PY_FLAVOR}
 RUN_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}pyerfa>=0:astro/py-pyerfa@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}astropy-iers-data>=0:astro/py-astropy-iers-data@${PY_FLAVOR}
 
 USES=		compiler:c11 python
-USE_PYTHON=	autoplist distutils
+USE_PYTHON=	autoplist cython3 distutils
 
 CONFLICTS_INSTALL=	p5-Data-ShowTable # bin/showtable
 
 .include <bsd.port.mk>
diff --git a/biology/py-bx-python/Makefile b/biology/py-bx-python/Makefile
index 2529daec6f1c..6b66a17d1250 100644
--- a/biology/py-bx-python/Makefile
+++ b/biology/py-bx-python/Makefile
@@ -1,27 +1,26 @@
 PORTNAME=	bx-python
 DISTVERSION=	0.13.0
 PORTREVISION=	1
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	${PORTNAME:S/-/_/}-${DISTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python module for reading, manipulating and writing genomic data sets
 WWW=		https://github.com/bxlab/bx-python
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 PY_DEPENDS=	${PYNUMPY}
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
-		${PY_DEPENDS}
+BUILD_DEPENDS=	${PY_DEPENDS}
 RUN_DEPENDS=	${PY_DEPENDS}
 
 USES=		compiler python
-USE_PYTHON=	distutils autoplist
+USE_PYTHON=	autoplist cython3 distutils
 
 post-install:
 	@${FIND} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/bx -name "*.so" | ${XARGS} ${STRIP_CMD}
 
 .include <bsd.port.mk>
diff --git a/biology/py-dnaio/Makefile b/biology/py-dnaio/Makefile
index 3baff38a1558..9bcb46dd389e 100644
--- a/biology/py-dnaio/Makefile
+++ b/biology/py-dnaio/Makefile
@@ -1,22 +1,21 @@
 PORTNAME=	dnaio
 DISTVERSION=	1.2.3
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	wen@FreeBSD.org
 COMMENT=	Read and write FASTQ and FASTA
 WWW=		https://github.com/marcelm/dnaio/
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PY_SETUPTOOLS} \
 		${PYTHON_PKGNAMEPREFIX}setuptools-scm>0:devel/py-setuptools-scm@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR}
+		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	autoplist pep517
+USE_PYTHON=	autoplist cython3 pep517
 
 .include <bsd.port.mk>
diff --git a/biology/py-macs3/Makefile b/biology/py-macs3/Makefile
index 6387fafd3346..bcb58abd2808 100644
--- a/biology/py-macs3/Makefile
+++ b/biology/py-macs3/Makefile
@@ -1,48 +1,47 @@
 PORTNAME=		MACS3
 DISTVERSIONPREFIX=	v
 DISTVERSION=		3.0.3
 CATEGORIES=		biology python
 PKGNAMEPREFIX=		${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Peak caller aimed at transcription factor binding sites
 WWW=		https://github.com/taoliu/MACS
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 NOT_FOR_ARCHS=	i386
 NOT_FOR_ARCHS_REASON_i386=Requires _Float16
 
 COMMON_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}scipy>1.11.1:science/py-scipy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}cykhash>=2.0,<3.0:devel/py-cykhash@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scikit-learn>=1.3:science/py-scikit-learn@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}hmmlearn>=0.3.2:math/py-hmmlearn@${PY_FLAVOR}
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR} \
 		simde>0:devel/simde \
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3 \
 		${COMMON_DEPENDS}
 RUN_DEPENDS=	${COMMON_DEPENDS}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest>0:devel/py-pytest@${PY_FLAVOR} \
 		bash:shells/bash
 
 USES=		localbase perl5 python shebangfix
 USE_GITHUB=	yes
 USE_PERL5=	test
-USE_PYTHON=	autoplist concurrent distutils
+USE_PYTHON=	autoplist concurrent cython3 distutils
 
 GH_ACCOUNT=	macs3-project
 GH_PROJECT=	MACS
 SHEBANG_FILES=	test/cmdlinetest* test/prockreport test/*.py test/pyprofile*
 
 post-stage:
 	${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/MACS3/*/*.so
 
 # FIXME: Some tests fail due to a py-threadpoolctl issue
 # https://github.com/joblib/threadpoolctl/pull/148
 do-test: deinstall reinstall
 	@${RM} -rf ${WRKSRC}/temp
 	@cd ${WRKSRC}/test && ./cmdlinetest tag
 
 .include <bsd.port.mk>
diff --git a/biology/py-pyrodigal/Makefile b/biology/py-pyrodigal/Makefile
index 69fe87cb7ad2..d4dfc118e33b 100644
--- a/biology/py-pyrodigal/Makefile
+++ b/biology/py-pyrodigal/Makefile
@@ -1,33 +1,32 @@
 PORTNAME=	pyrodigal
 DISTVERSION=	3.6.3
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python binding for Prodigal, an ORF finder for genomes and metagenomes
 WWW=		https://pyrodigal.readthedocs.io/en/stable/ \
 		https://github.com/althonos/pyrodigal
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/COPYING
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}scikit-build-core>0:devel/py-scikit-build-core@${PY_FLAVOR}
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}scikit-build-core>0:devel/py-scikit-build-core@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}archspec>0:devel/py-archspec@${PY_FLAVOR}
 
 USES=		cmake:indirect python
-USE_PYTHON=	pep517 concurrent autoplist pytest # cython: cython3 isn't yet supported by python.mk
+USE_PYTHON=	autoplist concurrent cython3 pep517 pytest
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 xpost-build:
 	@cd ${BUILD_WRKSRC} && ${SETENV} ${MAKE_ENV} ${PYTHON_CMD} setup.py build_ext --inplace
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/pyrodigal/lib${PYTHON_EXT_SUFFIX}.so
 
 do-test: # as of 3.6.3 this doesn't work: https://github.com/althonos/pyrodigal/issues/63
 	@cd ${TEST_WRKSRC} && ${SETENV} ${TEST_ENV} ${PYTHON_CMD} -m unittest discover -vv
 
 .include <bsd.port.mk>
diff --git a/comms/py-libimobiledevice/Makefile b/comms/py-libimobiledevice/Makefile
index f44618dab70e..35fc77e525c1 100644
--- a/comms/py-libimobiledevice/Makefile
+++ b/comms/py-libimobiledevice/Makefile
@@ -1,46 +1,45 @@
 PORTREVISION=	0
 CATEGORIES=	comms python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	jhale@FreeBSD.org
 COMMENT=	Python bindings for libimobiledevice
 
 LIB_DEPENDS=	libimobiledevice-1.0.so:${MASTER_PORT} \
 		libplist-2.0.so:devel/libplist
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}libplist>=2.2.0:devel/py-libplist@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}cython3>=3.0.0:lang/cython3@${PY_FLAVOR}
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}libplist>=2.2.0:devel/py-libplist@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}libplist>=2.2.0:devel/py-libplist@${PY_FLAVOR}
 
 USES+=		python
-USE_PYTHON=	flavors
+USE_PYTHON=	cython3 flavors
 
 CONFIGURE_ENV=	PYTHON_LDFLAGS="`pkg-config --libs python-${PYTHON_VER}`"
 
 BINARY_ALIAS=	cython=cython-${PYTHON_VER}
 MASTERDIR=	${.CURDIR:H:H}/comms/libimobiledevice
 PORTSCOUT=	ignore:1
 
 BUILD_WRKSRC=	${WRKSRC}/cython
 INSTALL_WRKSRC=	${BUILD_WRKSRC}
 
 PLIST=		${.CURDIR}/pkg-plist
 PLIST_FILES=	include/imobiledevice/cython/imobiledevice.pxd \
 		${PYTHONPREFIX_SITELIBDIR:S|^${PREFIX}/||}/imobiledevice.a \
 		${PYTHONPREFIX_SITELIBDIR:S|^${PREFIX}/||}/imobiledevice.so
 
 _USES_configure+=	471:post-autoreconf
 
 SLAVE_PORT=	yes
 
 post-autoreconf:
 	@${REINPLACE_CMD} \
 		-e 's|$$(top_builddir)/src/libimobiledevice-1.0.la|-limobiledevice-1.0|' \
 		-e 's|$$(imobiledevice_la_DEPENDENCIES)||' \
 		${BUILD_WRKSRC}/Makefile.in
 
 post-install:
 	@${MKDIR} ${STAGEDIR}${PREFIX}/include/imobiledevice/cython
 	${INSTALL_DATA} ${INSTALL_WRKSRC}/imobiledevice.pxd \
 		${STAGEDIR}${PREFIX}/include/imobiledevice/cython
 
 .include "${MASTERDIR}/Makefile"
diff --git a/converters/py-rencode/Makefile b/converters/py-rencode/Makefile
index 06b157739c4f..589cec228dad 100644
--- a/converters/py-rencode/Makefile
+++ b/converters/py-rencode/Makefile
@@ -1,37 +1,36 @@
 PORTNAME=	rencode
 PORTVERSION=	1.0.6
 PORTREVISION=	2
 CATEGORIES=	converters devel python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	Web safe object pickling/unpickling
 WWW=		https://github.com/aresch/rencode
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/COPYING
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}setuptools>0:devel/py-setuptools@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 
 USES=		cpe python
 CPE_VENDOR=	${PORTNAME}_project
-USE_PYTHON=	autoplist pep517
+USE_PYTHON=	autoplist cython3 pep517
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	aresch
 GH_TAGNAME=	572ff74586d9b1daab904c6f7f7009ce0143bb75
 
 # Make setup.py test target work with setup.py:test_suite
 # See: files/patch-setup.py
 post-patch:
 	${TOUCH} ${WRKSRC}/tests/__init__.py
 
 post-install:
 	${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/rencode/_rencode*.so
 
 do-test:
 	cd ${WRKSRC} && ${PYTHON_CMD} ${PYDISTUTILS_SETUP} test
 
 .include <bsd.port.mk>
diff --git a/databases/py-snowflake-connector-python/Makefile b/databases/py-snowflake-connector-python/Makefile
index 2f4dcef617b8..d6693a8d8b05 100644
--- a/databases/py-snowflake-connector-python/Makefile
+++ b/databases/py-snowflake-connector-python/Makefile
@@ -1,41 +1,40 @@
 PORTNAME=	snowflake-connector-python
 DISTVERSION=	3.12.3
 PORTREVISION=	1
 DISTNAME=	snowflake_connector_python-${DISTVERSION}
 CATEGORIES=	databases python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	pat@patmaddox.com
 COMMENT=	Snowflake Connector for Python
 WWW=		https://github.com/snowflakedb/snowflake-connector-python
 
 LICENSE=	APACHE20
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}asn1crypto>0.24.0<2.0.0:devel/py-asn1crypto@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}cffi>=1.9<2:devel/py-cffi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}openssl>=16.2.0:security/py-openssl@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pyjwt<3.0:www/py-pyjwt@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytz>0:devel/py-pytz@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests<3.0:www/py-requests@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}packaging>0:devel/py-packaging@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}charset-normalizer>=2<4:textproc/py-charset-normalizer@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}idna>=2.5<4.0:dns/py-idna@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}certifi>=2017.4.17:security/py-certifi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}typing-extensions>=4.3<5.0:devel/py-typing-extensions@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}filelock>=3.5<4.0:sysutils/py-filelock@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}sortedcontainers>=2.4.0:devel/py-sortedcontainers@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}platformdirs>=2.6.0<5.0.0:devel/py-platformdirs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tomlkit>0:textproc/py-tomlkit@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	autoplist concurrent cryptography distutils
+USE_PYTHON=	autoplist concurrent cryptography cython3 distutils
 
 .include <bsd.port.pre.mk>
 
 .if ${PYTHON_REL} < 31000
 RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}urllib3>=1.21.1:net/py-urllib3@${PY_FLAVOR}
 .endif
 
 .include <bsd.port.post.mk>
diff --git a/devel/py-ewah-bool-utils/Makefile b/devel/py-ewah-bool-utils/Makefile
index 87bd17ad29e9..dd5e7943d647 100644
--- a/devel/py-ewah-bool-utils/Makefile
+++ b/devel/py-ewah-bool-utils/Makefile
@@ -1,33 +1,32 @@
 PORTNAME=	ewah-bool-utils
 DISTVERSION=	1.1.0
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	${PORTNAME:S/-/_/g}-${PORTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	EWAH Bool Array utils for yt
 WWW=		https://github.com/yt-project/ewah_bool_utils
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PY_SETUPTOOLS} \
-		${PYTHON_PKGNAMEPREFIX}cython3>=3.0:lang/cython3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0.37.1:devel/py-wheel@${PY_FLAVOR} \
 		${PYNUMPY}
 RUN_DEPENDS=	${PYNUMPY}
 
 USES=		python
-USE_PYTHON=	pep517 autoplist pytest
+USE_PYTHON=	autoplist cython3 pep517 pytest
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR} # tests fail to run, see https://github.com/yt-project/ewah_bool_utils/issues/41
 TEST_WRKSRC=	${WRKSRC}/tests
 
 post-install:
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/ewah_bool_utils/_testing${PYTHON_EXT_SUFFIX}.so \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/ewah_bool_utils/ewah_bool_wrap${PYTHON_EXT_SUFFIX}.so \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/ewah_bool_utils/morton_utils${PYTHON_EXT_SUFFIX}.so
 
 .include <bsd.port.mk>
diff --git a/devel/py-frozenlist/Makefile b/devel/py-frozenlist/Makefile
index 4af64e1311c0..347ba9e9727d 100644
--- a/devel/py-frozenlist/Makefile
+++ b/devel/py-frozenlist/Makefile
@@ -1,28 +1,27 @@
 PORTNAME=	frozenlist
 PORTVERSION=	1.5.0
 PORTREVISION=	1
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	List-like structure which implements collections.abc.MutableSequence
 WWW=		https://github.com/aio-libs/frozenlist
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}expandvars>=0:devel/py-expandvars@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=47:devel/py-setuptools@${PY_FLAVOR} \
 		${PY_TOMLI} \
-		${PYTHON_PKGNAMEPREFIX}cython3>=3.0.0.b.1:lang/cython3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest-cov>=0:devel/py-pytest-cov@${PY_FLAVOR}
 
 USES=		gettext-runtime python
-USE_PYTHON=	autoplist concurrent pep517 pytest
+USE_PYTHON=	autoplist concurrent cython3 pep517 pytest
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/devel/py-gevent/Makefile b/devel/py-gevent/Makefile
index dd5e428882c0..c7f86e60793d 100644
--- a/devel/py-gevent/Makefile
+++ b/devel/py-gevent/Makefile
@@ -1,53 +1,52 @@
 PORTNAME=	gevent
 PORTVERSION=	24.2.1
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python co-routine networking library based on greenlet
 WWW=		https://www.gevent.org/ \
 		https://python-gevent.readthedocs.io/ \
 		https://github.com/gevent/gevent
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	c-ares>=1.15.0:dns/c-ares \
 		libev>=4.31:devel/libev \
 		libuv>=1.34.0:devel/libuv \
 		${PYTHON_PKGNAMEPREFIX}cffi>=1.12.3:devel/py-cffi@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}cython3>=3.0.8:lang/cython3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}greenlet>=3.0.3:devel/py-greenlet@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=40.8.0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libcares.so:dns/c-ares \
 		libev.so:devel/libev \
 		libuv.so:devel/libuv
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.12.3:devel/py-cffi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}greenlet>=3.0.3:devel/py-greenlet@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}zope.event>=0:devel/py-zope.event@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}zope.interface>=0:devel/py-zope.interface@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}sqlite3>=0:databases/py-sqlite3@${PY_FLAVOR}
 
 USES=		compiler:c11 localbase python
-USE_PYTHON=	autoplist concurrent pep517
+USE_PYTHON=	autoplist concurrent cython3 pep517
 
 MAKE_ENV=	GEVENTSETUP_EMBED_CARES=0 GEVENTSETUP_EMBED_LIBEV=0 GEVENTSETUP_EMBED_LIBUV=0
 TEST_ENV=	PYTHONPATH=${STAGEDIR}${PYTHON_SITELIBDIR}
 
 # Clean up bundled libraries
 .if !defined(MAINTAINER_MODE)
 EXTRACT_AFTER_ARGS=	--exclude ${DISTNAME}/deps \
 			--no-same-owner --no-same-permissions
 .else
 	@${RM} -r ${WRKSRC}/deps/
 .endif
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 do-test:
 	cd ${WRKSRC} && ${SETENV} ${TEST_ENV} ${PYTHON_CMD} -m gevent.tests
 
 .include <bsd.port.mk>
diff --git a/devel/py-libplist/Makefile b/devel/py-libplist/Makefile
index ad3bb9b9d1c1..e4d97860fb00 100644
--- a/devel/py-libplist/Makefile
+++ b/devel/py-libplist/Makefile
@@ -1,38 +1,37 @@
 PORTREVISION=	0
 CATEGORIES=	devel python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	jhale@FreeBSD.org
 COMMENT=	Python bindings for libplist
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>=3.0.0:lang/cython3@${PY_FLAVOR}
 LIB_DEPENDS=	libplist-2.0.so:${MASTER_PORT}
 
 USES+=		localbase:ldflags python
-USE_PYTHON=	flavors
+USE_PYTHON=	cython3 flavors
 
 CONFIGURE_ENV=	PYTHON_LDFLAGS="`pkg-config --libs python-${PYTHON_VER}`"
 
 BINARY_ALIAS=	cython=cython-${PYTHON_VER}
 MASTERDIR=	${.CURDIR:H:H}/devel/libplist
 PORTSCOUT=	ignore:1
 
 BUILD_WRKSRC=	${WRKSRC}/cython
 INSTALL_WRKSRC=	${BUILD_WRKSRC}
 
 PLIST=		${.CURDIR}/pkg-plist
 PLIST_FILES=	include/plist/cython/plist.pxd \
 		${PYTHONPREFIX_SITELIBDIR:S|^${PREFIX}/||}/plist.so
 
 SLAVE_PORT=	yes
 
 pre-configure:
 	@${REINPLACE_CMD} -e 's|$$(top_builddir)/src/libplist-2.0.la|-lplist-2.0|' \
 		${BUILD_WRKSRC}/Makefile.am
 
 post-install:
 	@${MKDIR} ${STAGEDIR}${PREFIX}/include/plist/cython
 	${INSTALL_DATA} ${INSTALL_WRKSRC}/plist.pxd \
 		${STAGEDIR}${PREFIX}/include/plist/cython
 
 .include "${MASTERDIR}/Makefile"
diff --git a/devel/py-line-profiler/Makefile b/devel/py-line-profiler/Makefile
index 6c9df8b769ef..68e6a134434d 100644
--- a/devel/py-line-profiler/Makefile
+++ b/devel/py-line-profiler/Makefile
@@ -1,33 +1,32 @@
 PORTNAME=	line-profiler
 DISTVERSION=	4.1.3
 PORTREVISION=	1
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	${PORTNAME:S/-/_/}-${PORTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Line-by-line profiler for Python
 WWW=		https://github.com/pyutils/line_profiler
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}scikit-build>0:devel/py-scikit-build@${PY_FLAVOR} \
-		cmake:devel/cmake-core \
-		${PYTHON_PKGNAMEPREFIX}cython3>=0:lang/cython3@${PY_FLAVOR}
+		cmake:devel/cmake-core
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}coverage>=5.3:devel/py-coverage@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}ipython>=0.13:devel/ipython@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-cov>=3.0.0:devel/py-pytest-cov@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}ubelt>=1.3.4:devel/py-ubelt@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}xdoctest>=1.1.3:devel/py-xdoctest@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	distutils cython autoplist pytest # 7 tests fail, see https://github.com/pyutils/line_profiler/issues/266
+USE_PYTHON=	autoplist cython3 distutils pytest # 7 tests fail, see https://github.com/pyutils/line_profiler/issues/266
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/line_profiler/_line_profiler${PYTHON_EXT_SUFFIX}.so
 
 .include <bsd.port.mk>
diff --git a/devel/py-lxml5/Makefile b/devel/py-lxml5/Makefile
index 4e1f4d291c11..d910e53d2d32 100644
--- a/devel/py-lxml5/Makefile
+++ b/devel/py-lxml5/Makefile
@@ -1,30 +1,29 @@
 PORTNAME=	lxml
 PORTVERSION=	5.3.1
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI \
 		https://github.com/lxml/lxml/releases/download/lxml-${PORTVERSION}/
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 PKGNAMESUFFIX=	5
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Pythonic XML processing library combining libxml2/libxslt
 WWW=		https://lxml.de/ \
 		https://github.com/lxml/lxml
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>=3.0.11<3.1.0:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 
 USES=		cpe gnome python
 USE_GNOME=	libxml2 libxslt
-USE_PYTHON=	autoplist concurrent pep517
+USE_PYTHON=	autoplist concurrent cython3 pep517
 
 CONFLICTS_INSTALL=	${PYTHON_PKGNAMEPREFIX}lxml ${PYTHON_PKGNAMEPREFIX}lxml5
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/devel/py-propcache/Makefile b/devel/py-propcache/Makefile
index fb89cfe80b2b..fa751e94e0ee 100644
--- a/devel/py-propcache/Makefile
+++ b/devel/py-propcache/Makefile
@@ -1,27 +1,26 @@
 PORTNAME=	propcache
 PORTVERSION=	0.3.0
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Accelerated property cache
 WWW=		https://propcache.aio-libs.org/en/latest/ \
 		https://github.com/aio-libs/propcache
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>=3.0.12<3.1.0:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}expandvars>=0:devel/py-expandvars@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}expandvars>=0:devel/py-expandvars@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PY_TOMLI} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 
 USES=		python:3.9+
-USE_PYTHON=	autoplist concurrent pep517
+USE_PYTHON=	autoplist concurrent cython3 pep517
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/devel/py-pykdtree/Makefile b/devel/py-pykdtree/Makefile
index c022d197a10d..e72d7b52ed05 100644
--- a/devel/py-pykdtree/Makefile
+++ b/devel/py-pykdtree/Makefile
@@ -1,26 +1,25 @@
 PORTNAME=	pykdtree
 PORTVERSION=	1.4.1
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Fast kd-tree implementation with OpenMP-enabled queries
 WWW=		https://github.com/storpipfugl/pykdtree
 
 LICENSE=	LGPL3
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>=0:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR}
 
 USES=		python:3.9+
-USE_PYTHON=	autoplist concurrent pep517
+USE_PYTHON=	autoplist concurrent cython3 pep517
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/devel/py-qutip/Makefile b/devel/py-qutip/Makefile
index 7f8e96349fea..a2ec6c465624 100644
--- a/devel/py-qutip/Makefile
+++ b/devel/py-qutip/Makefile
@@ -1,41 +1,39 @@
 PORTNAME=	qutip
 DISTVERSION=	5.0.4
 CATEGORIES=	devel
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Quantum toolbox in python
 WWW=		https://qutip.org/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 PY_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}matplotlib>0:math/py-matplotlib@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}packaging>0:devel/py-packaging@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=1.9:science/py-scipy@${PY_FLAVOR}
 BUILD_DEPENDS=	${PY_DEPENDS} \
 		${PY_SETUPTOOLS} \
-		${PYTHON_PKGNAMEPREFIX}cython3>=3.0.0:lang/cython3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pip>0:devel/py-pip@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0.32.0:devel/py-wheel@${PY_FLAVOR}
-RUN_DEPENDS=	${PY_DEPENDS} \
-		${PYTHON_PKGNAMEPREFIX}cython3>=3.0.0:lang/cython3@${PY_FLAVOR}
+RUN_DEPENDS=	${PY_DEPENDS}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}nose>0:devel/py-nose@${PY_FLAVOR}
 # the optional graphics/py-mayavi dependency is omitted because it is python-2.7 -only
 
 USES=		python
-USE_PYTHON=	pep517 autoplist
+USE_PYTHON=	autoplist cython3 cython3_run pep517
 
 post-install:
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/qutip/*/*${PYTHON_EXT_SUFFIX}.so \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/qutip/*/*/*${PYTHON_EXT_SUFFIX}.so
 
 do-test: # 3 tests fail, see https://github.com/qutip/qutip/issues/2190
 	@${ECHO} "==> Running tests. Please note that tests require X11 display access."
 	@cd ${WRKDIR} && ${SETENV} ${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHON_SITELIBDIR} \
 		${PYTHON_CMD} -c "import qutip.testing as qt; qt.run();"
 
 .include <bsd.port.mk>
diff --git a/graphics/py-imagecodecs/Makefile b/graphics/py-imagecodecs/Makefile
index 169a33254a5f..e844ddf5387d 100644
--- a/graphics/py-imagecodecs/Makefile
+++ b/graphics/py-imagecodecs/Makefile
@@ -1,65 +1,64 @@
 PORTNAME=	imagecodecs
 PORTVERSION=	2024.12.30
 CATEGORIES=	graphics python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Image transformation, compression, and decompression codecs
 WWW=		https://github.com/cgohlke/imagecodecs
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>=3.0.11:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libaec.so:science/libaec \
 		libavif.so:graphics/libavif \
 		libblosc.so:archivers/c-blosc \
 		libblosc2.so:archivers/c-blosc2 \
 		libbrotlicommon.so:archivers/brotli \
 		libbrunslidec-c.so:graphics/brunsli \
 		libcharls.so:graphics/charls \
 		libdeflate.so:archivers/libdeflate \
 		libgif.so:graphics/giflib \
 		libheif.so:graphics/libheif \
 		libjbig.so:graphics/jbigkit\
 		libjpegxr.so:graphics/libjxr \
 		libjxl.so:graphics/libjxl \
 		liblcms2.so:graphics/lcms2 \
 		libLerc.so:graphics/lerc \
 		liblz4.so:archivers/liblz4 \
 		liblzfse.so:archivers/lzfse \
 		libopenjp2.so:graphics/openjpeg \
 		libpng16.so:graphics/png \
 		libsnappy.so:archivers/snappy \
 		libSZ3c.so:science/sz3 \
 		libtiff.so:graphics/tiff \
 		libuhdr.so:graphics/libultrahdr \
 		libwebp.so:graphics/webp \
 		libz-ng.so:archivers/zlib-ng \
 		libzfp.so:devel/zfp \
 		libzopfli.so:archivers/zopfli \
 		libzstd.so:archivers/zstd
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR}
 
 USES=		jpeg localbase python:3.9+
-USE_PYTHON=	autoplist concurrent pep517
+USE_PYTHON=	autoplist concurrent cython3 pep517
 
 CPPFLAGS+=	-I${LOCALBASE}/include/jxrlib \
 		-I${LOCALBASE}/include/openjpeg-2.5
 
 OPTIONS_DEFINE=	ALL
 ALL_DESC=	All optional dependencies
 
 # Remove graphics/py-tifffile from RUN_DEPENDS to avoid cyclic dependency
 ALL_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}matplotlib>=0:math/py-matplotlib@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}numcodecs>=0:misc/py-numcodecs@${PY_FLAVOR}
 #			${PYTHON_PKGNAMEPREFIX}tifffile>=0:graphics/py-tifffile@${PY_FLAVOR}
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/graphics/py-pandana/Makefile b/graphics/py-pandana/Makefile
index 0ae41739a1e5..5e67af375233 100644
--- a/graphics/py-pandana/Makefile
+++ b/graphics/py-pandana/Makefile
@@ -1,36 +1,35 @@
 PORTNAME=	pandana
 PORTVERSION=	0.6.1
 PORTREVISION=	4
 CATEGORIES=	graphics python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python library for network analysis
 WWW=		https://udst.github.io/pandana/ \
 		https://github.com/UDST/pandana
 
 LICENSE=	AGPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 .if !exists(/usr/include/omp.h)
 BROKEN=		requires OpenMP support that is missing on this architecture
 .endif
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>=0:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}numpy>=1.8,1:math/py-numpy@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=1.8,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=1.8,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pandas>=0.17,1:math/py-pandas@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>=2.0:www/py-requests@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scikit-learn>=0.18:science/py-scikit-learn@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tables>=3.1:devel/py-tables@${PY_FLAVOR}
 
 USES=		compiler:c++11-lang python
-USE_PYTHON=	autoplist concurrent pep517
+USE_PYTHON=	autoplist concurrent cython3 pep517
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/graphics/py-pyproj/Makefile b/graphics/py-pyproj/Makefile
index 34a61eafe44f..bca88cf33e6e 100644
--- a/graphics/py-pyproj/Makefile
+++ b/graphics/py-pyproj/Makefile
@@ -1,41 +1,40 @@
 PORTNAME=	pyproj
 PORTVERSION=	3.7.1
 CATEGORIES=	graphics geography python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Cython wrapper to provide python interfaces to PROJ.4 functions
 WWW=		https://pyproj4.github.io/pyproj/stable/ \
 		https://github.com/pyproj4/pyproj
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	proj>=9.2.0,1:graphics/proj \
-		${PYTHON_PKGNAMEPREFIX}cython3>=3:lang/cython3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=61.0.0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libproj.so:graphics/proj
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}certifi>=0:security/py-certifi@${PY_FLAVOR}
 
 USES=		python:3.10+
-USE_PYTHON=	autoplist concurrent pep517
+USE_PYTHON=	autoplist concurrent cython3 pep517
 
 MAKE_ENV=	PROJ_DIR=${LOCALBASE}
 
 OPTIONS_DEFINE=	DOCS EXAMPLES
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 post-install-DOCS-on:
 	@${MKDIR} ${STAGEDIR}${DOCSDIR}
 	${INSTALL_DATA} ${WRKSRC}/README.md ${STAGEDIR}${DOCSDIR}
 	cd ${WRKSRC}/docs/ && ${COPYTREE_SHARE} . ${STAGEDIR}${DOCSDIR}
 
 post-install-EXAMPLES-on:
 	@${MKDIR} ${STAGEDIR}${EXAMPLESDIR}
 	${INSTALL_DATA} ${WRKSRC}/test/sample.out ${WRKSRC}/test/test_*.py ${STAGEDIR}${EXAMPLESDIR}
 
 .include <bsd.port.mk>
diff --git a/graphics/py-simplejpeg/Makefile b/graphics/py-simplejpeg/Makefile
index 089d47b6b276..fcb92ac8a82b 100644
--- a/graphics/py-simplejpeg/Makefile
+++ b/graphics/py-simplejpeg/Makefile
@@ -1,33 +1,32 @@
 PORTNAME=	simplejpeg
 DISTVERSION=	1.8.0
 CATEGORIES=	graphics python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Simple package for fast JPEG encoding and decoding
 WWW=		https://gitlab.com/jfolz/simplejpeg
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PY_SETUPTOOLS} \
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 
 USES=		cmake:indirect python
-USE_PYTHON=	pep517 autoplist pytest
+USE_PYTHON=	autoplist cython3 pep517 pytest
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_WRKSRC=	${WRKSRC}/test
 
 post-extract: # force cythonization because pre-cythonized _jpeg.c fails to compile
 	@${RM} ${WRKSRC}/simplejpeg/_jpeg.c
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/simplejpeg/_jpeg${PYTHON_EXT_SUFFIX}.so
 
 # tests as of 1.8.0: 61 passed in 10.57s
 
 .include <bsd.port.mk>
diff --git a/graphics/py-vispy/Makefile b/graphics/py-vispy/Makefile
index 4b96f5d51cdc..99227b9a8052 100644
--- a/graphics/py-vispy/Makefile
+++ b/graphics/py-vispy/Makefile
@@ -1,33 +1,32 @@
 PORTNAME=	vispy
 DISTVERSION=	0.14.3
 CATEGORIES=	graphics science python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	High-performance interactive 2D/3D data visualization library
 WWW=		https://vispy.org/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>=3.0:lang/cython3@${PY_FLAVOR} \
-		${PYNUMPY} \
+BUILD_DEPENDS=	${PYNUMPY} \
 		${PY_SETUPTOOLS} \
 		${PYTHON_PKGNAMEPREFIX}setuptools-scm>=7.1:devel/py-setuptools-scm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}freetype-py>0:print/py-freetype-py@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}hsluv>0:graphics/py-hsluv@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}kiwisolver>0:math/py-kiwisolver@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}packaging>0:devel/py-packaging@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	pep517 autoplist pytest # pytest crashes on some tests, and then keeps restarting
+USE_PYTHON=	autoplist cython3 pep517 pytest # pytest crashes on some tests, and then keeps restarting
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/vispy/visuals/text/_sdf_cpu${PYTHON_EXT_SUFFIX}.so
 
 .include <bsd.port.mk>
diff --git a/japanese/py-fugashi/Makefile b/japanese/py-fugashi/Makefile
index ea88ac4e735e..4904f83c40b4 100644
--- a/japanese/py-fugashi/Makefile
+++ b/japanese/py-fugashi/Makefile
@@ -1,30 +1,29 @@
 PORTNAME=	fugashi
 DISTVERSION=	1.4.0
 CATEGORIES=	japanese python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Cython MeCab wrapper for fast, pythonic Japanese tokenization
 WWW=		https://github.com/polm/fugashi
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools-scm>0:devel/py-setuptools-scm@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libmecab.so:japanese/mecab
 RUN_DEPENDS=	ja-mecab-ipadic>0:japanese/mecab-ipadic
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}ipadic>0:japanese/py-ipadic@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	distutils autoplist pytest # many tests fail, see https://github.com/polm/fugashi/issues/102
+USE_PYTHON=	autoplist cython3 distutils pytest # many tests fail, see https://github.com/polm/fugashi/issues/102
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_WRKSRC=	${WRKSRC}/fugashi/tests
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/fugashi/fugashi${PYTHON_EXT_SUFFIX}.so
 
 .include <bsd.port.mk>
diff --git a/lang/py-lupa/Makefile b/lang/py-lupa/Makefile
index 00fb545e8557..d5a2ddccd3d2 100644
--- a/lang/py-lupa/Makefile
+++ b/lang/py-lupa/Makefile
@@ -1,37 +1,36 @@
 PORTNAME=	lupa
 PORTVERSION=	2.4
 CATEGORIES=	lang python
 MASTER_SITES=	PYPI \
 		https://github.com/scoder/lupa/releases/download/lupa-${PORTVERSION}/
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python wrapper around Lua and LuaJIT
 WWW=		https://github.com/scoder/lupa
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>=3.0.11<3.1:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 
 USES=		lua pkgconfig python
-USE_PYTHON=	autoplist concurrent pep517 unittest
+USE_PYTHON=	autoplist concurrent cython3 pep517 unittest
 
 MAKE_ARGS=	--no-bundle --with-cython --with-lua-checks
 TEST_ARGS=	lupa.tests.test
 
 # Clean up bundled libraries
 .if !defined(MAINTAINER_MODE)
 EXTRACT_AFTER_ARGS=	--exclude ${DISTNAME}/third-party \
 			--no-same-owner --no-same-permissions
 .else
 post-patch:
 	@${RM} -r ${WRKSRC}/third-party/
 .endif
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/math/py-CyLP/Makefile b/math/py-CyLP/Makefile
index 3991ffa4e668..24e953829189 100644
--- a/math/py-CyLP/Makefile
+++ b/math/py-CyLP/Makefile
@@ -1,46 +1,45 @@
 PORTNAME=	CyLP
 DISTVERSIONPREFIX=	v
 DISTVERSION=	0.92.3
 PORTREVISION=	1
 CATEGORIES=	math python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python interface to CLP, CBC, and CGL to solve LPs and MIPs
 WWW=		https://github.com/coin-or/CyLP
 
 LICENSE=	CPL10
 LICENSE_NAME=	Common Public License Version 1.0
 LICENSE_FILE=	${WRKSRC}/LICENSE
 LICENSE_PERMS=	auto-accept dist-mirror dist-sell pkg-mirror pkg-sell
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3 \
-		${PY_SETUPTOOLS} \
+BUILD_DEPENDS=	${PY_SETUPTOOLS} \
 		${PYTHON_PKGNAMEPREFIX}hypothesis>0:devel/py-hypothesis@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libblas.so:math/blas \
 		libCbc.so:math/cbc \
 		libCgl.so:math/cgl \
 		libClp.so:math/clp \
 		libCoinUtils.so:math/coinutils \
 		liblapack.so:math/lapack \
 		libOsi.so:math/osi
 RUN_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=0.10.0:science/py-scipy@${PY_FLAVOR}
 
 USES=		compiler:c++11-lang python
-USE_PYTHON=	pep517 cython autoplist pytest
+USE_PYTHON=	autoplist cython3 pep517 pytest
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	coin-or
 
 MAKE_ENV=	COIN_INSTALL_DIR=${LOCALBASE}
 
 TEST_WRKSRC=	${WRKSRC}/cylp
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/cylp/cy/Cy*.so
 
 .include <bsd.port.mk>
diff --git a/math/py-PySCIPOpt/Makefile b/math/py-PySCIPOpt/Makefile
index 4af40a48c925..0ca81978ffbe 100644
--- a/math/py-PySCIPOpt/Makefile
+++ b/math/py-PySCIPOpt/Makefile
@@ -1,33 +1,32 @@
 PORTNAME=	PySCIPOpt
 DISTVERSIONPREFIX=	v
 DISTVERSION=	5.4.1
 PORTREVISION=	1
 CATEGORIES=	math python
 #MASTER_SITES=	PYPI # no tests
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python interface and modeling environment for SCIP
 WWW=		https://github.com/SCIP-Interfaces/PySCIPOpt
 
 LICENSE=	MIT
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3
 LIB_DEPENDS=	libscip.so:math/SCIP
 RUN_DEPENDS=	${PYNUMPY}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}networkx>0:math/py-networkx@${PY_FLAVOR}
 
 USES=		localbase python
-USE_PYTHON=	distutils autoplist pytest # 1 test fails, see https://github.com/scipopt/PySCIPOpt/issues/840
+USE_PYTHON=	autoplist cython3 distutils pytest # 1 test fails, see https://github.com/scipopt/PySCIPOpt/issues/840
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	scipopt
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/pyscipopt/scip*.so
 
 # tests as of 5.3.0: 310 passed, 106 skipped, 11 xfailed, 4 warnings in 127.77s (0:02:07)
 
 .include <bsd.port.mk>
diff --git a/math/py-cypari2/Makefile b/math/py-cypari2/Makefile
index 215c1fdc9623..715f0408b805 100644
--- a/math/py-cypari2/Makefile
+++ b/math/py-cypari2/Makefile
@@ -1,38 +1,37 @@
 PORTNAME=	cypari2
 PORTVERSION=	2.2.1
 CATEGORIES=	math python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	thierry@FreeBSD.org
 COMMENT=	Python interface to the number theory library PARI/GP
 WWW=		https://github.com/sagemath/cypari2
 
 LICENSE=	GPLv2
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR}	\
-		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}	\
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}	\
 		${PYTHON_PKGNAMEPREFIX}cysignals>0:devel/py-cysignals@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR}
 LIB_DEPENDS=	libgmp.so:math/gmp	\
 		libpari.so:math/pari
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cysignals>0:devel/py-cysignals@${PY_FLAVOR}
 TEST_DEPENDS=	py.test:devel/py-pytest@${PY_FLAVOR}	\
 		${PYTHON_PKGNAMEPREFIX}flaky>=3.8.1:devel/py-flaky@${PY_FLAVOR}
 
 #USE_GITHUB=	yes
 #GH_ACCOUNT=	sagemath
 
 USES=		compiler:c11 python
-USE_PYTHON=	pep517
+USE_PYTHON=	cython3 pep517
 
 .if !defined(WITH_DEBUG)
 LDFLAGS+=	-s
 .endif
 
 PLIST_SUB+=	VER=${DISTVERSION}
 
 do-test: install
 	(cd ${WRKSRC} && py.test)
 
 .include <bsd.port.mk>
diff --git a/math/py-fpylll/Makefile b/math/py-fpylll/Makefile
index f028cd56e63a..70cec1723019 100644
--- a/math/py-fpylll/Makefile
+++ b/math/py-fpylll/Makefile
@@ -1,57 +1,56 @@
 PORTNAME=	fpylll
 PORTVERSION=	0.6.3
 PORTREVISION=	1
 CATEGORIES=	math python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	thierry@FreeBSD.org
 COMMENT=	Python interface for fplll
 WWW=		https://github.com/fplll/fpylll
 
 LICENSE=	GPLv2
 
 BUILD_DEPENDS=	${PYNUMPY}	\
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR}	\
 		${PYTHON_PKGNAMEPREFIX}black>0:devel/py-black@${PY_FLAVOR}	\
 		${PYTHON_PKGNAMEPREFIX}pythran>0:devel/py-pythran@${PY_FLAVOR}	\
 		${PYTHON_PKGNAMEPREFIX}cysignals>0:devel/py-cysignals@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR}
 LIB_DEPENDS=	libfplll.so:math/fplll	\
 		libgmp.so:math/gmp	\
 		libmpfr.so:math/mpfr	\
 		libpari.so:math/pari	\
 		libqd.so:math/qd
 RUN_DEPENDS=	${PYNUMPY}	\
 		${PYTHON_PKGNAMEPREFIX}black>0:devel/py-black@${PY_FLAVOR}	\
 		${PYTHON_PKGNAMEPREFIX}pythran>0:devel/py-pythran@${PY_FLAVOR}	\
 		${PYTHON_PKGNAMEPREFIX}cysignals>0:devel/py-cysignals@${PY_FLAVOR}
 TEST_DEPENDS=	py.test:devel/py-pytest@${PY_FLAVOR}
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	fplll
 
 USES=		compiler:c++11-lang python
-USE_PYTHON=	distutils
+USE_PYTHON=	cython3 distutils
 .if !defined(WITH_DEBUG)
 LDFLAGS+=	-s
 .endif
 
 OPTIONS_DEFINE=		TUTO
 TUTO_DESC=		Build the tutorial
 OPTIONS_SUB=		Yes
 TUTO_BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}sphinx>=1.6,1:textproc/py-sphinx@${PY_FLAVOR}
 TUTO_USES=		gmake
 
 PLIST_SUB=	VER=${PORTVERSION:R}
 
 do-build-TUTO-on:
 	(cd ${WRKSRC}/docs && ${GMAKE} html)
 
 post-build-TUTO-on:
 	${MKDIR} ${STAGEDIR}${DOCSDIR}
 	${CP} -R ${WRKSRC}/docs/_build/html/* ${STAGEDIR}${DOCSDIR}
 
 do-test: install
 	(cd ${WRKSRC} && PY_IGNORE_IMPORTMISMATCH=1 py.test)
 
 .include <bsd.port.mk>
diff --git a/math/py-linearmodels/Makefile b/math/py-linearmodels/Makefile
index abaf49b62e8d..1716a6ea6872 100644
--- a/math/py-linearmodels/Makefile
+++ b/math/py-linearmodels/Makefile
@@ -1,45 +1,44 @@
 PORTNAME=	linearmodels
 DISTVERSION=	6.1
 PORTREVISION=	1
 CATEGORIES=	math python # statistics
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Linear Panel, Instrumental Variable, Asset Pricing and other models
 WWW=		https://bashtage.github.io/linearmodels/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.md
 
 PY_DEPENDS=	${PYTHON_PKGNAMEPREFIX}formulaic>=1.0.0:math/py-formulaic@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}mypy_extensions>=0.4:devel/py-mypy_extensions@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}pandas>=1.4.0:math/py-pandas@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}property-cached>=1.6.3:devel/py-property-cached@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pyhdfe>=0.1:math/py-pyhdfe@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=1.8.0:science/py-scipy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}statsmodels>=0.13.0:math/py-statsmodels@${PY_FLAVOR}
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}setuptools-scm>0:devel/py-setuptools-scm@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools-scm>0:devel/py-setuptools-scm@${PY_FLAVOR} \
 		${PY_DEPENDS}
 RUN_DEPENDS=	${PY_DEPENDS}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}black>0:devel/py-black@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}coverage>0:devel/py-coverage@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}flake8>0:devel/py-flake8@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}isort>0:devel/py-isort@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}matplotlib>0:math/py-matplotlib@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-cov>0:devel/py-pytest-cov@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-xdist>0:devel/py-pytest-xdist@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}seaborn>0:math/py-seaborn@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}xarray>=0.13:devel/py-xarray@${PY_FLAVOR}
 
 USES=		python shebangfix
-USE_PYTHON=	distutils autoplist pytest # 14 tests fail, see https://github.com/bashtage/linearmodels/issues/550
+USE_PYTHON=	autoplist cython3 distutils pytest # 14 tests fail, see https://github.com/bashtage/linearmodels/issues/550
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/linearmodels/panel/_utility${PYTHON_EXT_SUFFIX}.so
 
 .include <bsd.port.mk>
diff --git a/math/py-pandas/Makefile b/math/py-pandas/Makefile
index 30ee348a02f0..956fd1610b28 100644
--- a/math/py-pandas/Makefile
+++ b/math/py-pandas/Makefile
@@ -1,98 +1,97 @@
 PORTNAME=	pandas
 PORTVERSION=	2.2.3
 PORTEPOCH=	1
 CATEGORIES=	math devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	Flexible, high-performance data analysis in Python
 WWW=		https://pandas.pydata.org \
 		https://pandas.pydata.org/docs/ \
 		https://github.com/pandas-dev/pandas
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3 \
-		meson>=1.2.1:devel/meson@${PY_FLAVOR} \
+BUILD_DEPENDS=	meson>=1.2.1:devel/meson@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}meson-python>=0.13.1:devel/meson-python@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}numpy>=1.26.0,1<2,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}versioneer>=0:devel/py-versioneer@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=1.26.0,1<2,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}python-dateutil>=2.8.2:devel/py-python-dateutil@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytz>=2020.1,1:devel/py-pytz@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}sqlite3>=0:databases/py-sqlite3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tzdata>=2022.7:devel/py-tzdata@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}arrow>=0:devel/py-arrow@${PY_FLAVOR}
 
 USES=		cpe python
-USE_PYTHON=	autoplist concurrent pep517 pytest
+USE_PYTHON=	autoplist concurrent cython3 pep517 pytest
 
 CPE_VENDOR=	numfocus
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_WRKSRC=	${WRKSRC}/pandas
 
 OPTIONS_DEFINE=		MPL SCIPY
 OPTIONS_GROUP=		ACCEL STORAGE HTML EXCEL
 OPTIONS_RADIO=		SQL
 OPTIONS_GROUP_ACCEL=	BTLNCK NUMEXPR
 OPTIONS_GROUP_STORAGE=	BOTO TABLES
 OPTIONS_GROUP_HTML=	LXML HTML5LIB JINJA2
 OPTIONS_GROUP_EXCEL=	XLRD XLWT OPENPYXL XLSX
 OPTIONS_RADIO_SQL=	ALCHEMY14 ALCHEMY20
 OPTIONS_DEFAULT=	BTLNCK NUMEXPR
 
 # Note: we cannot include the following ports in *_DEPENDS because they depend
 # on us for BUILD and RUN.
 #	devel/py-xarray
 #	math/py-statsmodels
 ACCEL_DESC=	Computation Acceleration Add-ons
 ALCHEMY14_DESC=	Support SQL databases via databases/py-sqlalchemy14
 ALCHEMY20_DESC=	Support SQL databases via databases/py-sqlalchemy20
 BOTO_DESC=	Support Amazon S3 storage via devel/py-boto
 BTLNCK_DESC=	Accelerate certain NaN evals via math/py-bottleneck
 EXCEL_DESC=	MS Excel I/O Add-ons
 HTML5LIB_DESC=	Parse HTML with www/py-html5lib and www/py-beautifulsoup
 HTML_DESC=	HTML Parsing/Generation Add-ons
 JINJA2_DESC=	Support conditional HTML formatting with devel/py-Jinja2
 LXML_DESC=	Parse HTML with devel/py-lxml and www/py-beautifulsoup
 MPL_DESC=	Support graphical plotting output via math/py-matplotlib
 NUMEXPR_DESC=	Accelerate certain numerical ops via math/py-numexpr
 OPENPYXL_DESC=	Write MS Excel 2007+ with textproc/py-openpyxl
 OPENPYXL_IMPLIES=	XLRD
 SCIPY_DESC=	Support various statistical functions via science/py-scipy
 SQL_DESC=	SQLAlchemy ORM Add-ons
 STORAGE_DESC=	Data Storage Add-ons
 TABLES_DESC=	Support HDF5-based storage via devel/py-tables
 XLRD_DESC=	Read MS Excel with textproc/py-xlrd
 XLSX_DESC=	Write MS Excel with textproc/py-xlsxwriter
 XLWT_DESC=	Write MS Excel with textproc/py-xlwt
 
 ALCHEMY14_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}sqlalchemy14>0:databases/py-sqlalchemy14@${PY_FLAVOR}
 ALCHEMY20_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}sqlalchemy20>0:databases/py-sqlalchemy20@${PY_FLAVOR}
 BOTO_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}boto>0:devel/py-boto@${PY_FLAVOR}
 BTLNCK_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}bottleneck>=1.2.0:math/py-bottleneck@${PY_FLAVOR}
 HTML5LIB_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}beautifulsoup>=4.2.1:www/py-beautifulsoup@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}html5lib>0:www/py-html5lib@${PY_FLAVOR}
 JINJA2_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}Jinja2>0:devel/py-Jinja2@${PY_FLAVOR}
 LXML_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}beautifulsoup>=4.2.1:www/py-beautifulsoup@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}lxml>0:devel/py-lxml@${PY_FLAVOR}
 MPL_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}matplotlib>=2.0.0:math/py-matplotlib@${PY_FLAVOR}
 NUMEXPR_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numexpr>=2.6.1:math/py-numexpr@${PY_FLAVOR}
 OPENPYXL_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}openpyxl>=2.4.0:textproc/py-openpyxl@${PY_FLAVOR}
 SCIPY_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}scipy>=1.1:science/py-scipy@${PY_FLAVOR}
 TABLES_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}tables>=3.4.2:devel/py-tables@${PY_FLAVOR}
 XLRD_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}xlrd>=1.0.0:textproc/py-xlrd@${PY_FLAVOR}
 XLSX_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}XlsxWriter>0:textproc/py-xlsxwriter@${PY_FLAVOR}
 XLWT_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}xlwt>0:textproc/py-xlwt@${PY_FLAVOR}
 
 post-install:
 	@${FIND} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 do-test:
 	@cd ${TEST_WRKSRC} && ${SETENV} ${TEST_ENV} ${PYTHON_CMD} -c "import pandas; pandas.test()"
 
 .include <bsd.port.mk>
diff --git a/math/py-petsc4py/Makefile b/math/py-petsc4py/Makefile
index 781cec7f9313..4a36a7f2d0b9 100644
--- a/math/py-petsc4py/Makefile
+++ b/math/py-petsc4py/Makefile
@@ -1,39 +1,38 @@
 PORTNAME=	petsc4py
 DISTVERSION=	3.22.4
 CATEGORIES=	math python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	PETSc for Python
 WWW=		https://gitlab.com/petsc/petsc
 
 LICENSE=	BSD2CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.rst
 
 BROKEN_armv7=	compilation fails: LLVM ERROR: out of memory
 
-BUILD_DEPENDS=	${PYNUMPY} \
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3
+BUILD_DEPENDS=	${PYNUMPY}
 LIB_DEPENDS=	libpetsc.so:science/PETSc
 RUN_DEPENDS=	${PYNUMPY}
 
 USES=		python
-USE_PYTHON=	distutils autoplist pytest # tests fail to run, see https://gitlab.com/petsc/petsc/-/issues/1301
+USE_PYTHON=	autoplist cython3 distutils pytest # tests fail to run, see https://gitlab.com/petsc/petsc/-/issues/1301
 
 MAKE_ENV=	PETSC_DIR=${LOCALBASE}
 
 OPTIONS_SINGLE=		MPI
 OPTIONS_SINGLE_MPI=	MPICH OPENMPI
 OPTIONS_DEFAULT=	MPICH
 
 MPICH_USES=		mpi:mpich
 
 OPENMPI_USES=		mpi:openmpi
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/petsc4py/lib/PETSc${PYTHON_EXT_SUFFIX}.so
 
 .include <bsd.port.mk>
diff --git a/math/py-primme/Makefile b/math/py-primme/Makefile
index a76aeef52a04..15011d35bb3a 100644
--- a/math/py-primme/Makefile
+++ b/math/py-primme/Makefile
@@ -1,38 +1,37 @@
 PORTNAME=	primme
 DISTVERSION=	3.2.3
 PORTREVISION=	1
 CATEGORIES=	math python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	PRIMME wrapper for Python
 WWW=		https://www.cs.wm.edu/~andreas/software/ \
 		https://github.com/primme/primme
 
 LICENSE=	BSD3CLAUSE
 
 BUILD_DEPENDS=	${PY_SETUPTOOLS} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}scipy>0:science/py-scipy@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libprimme.so:math/primme \
 		libblas.so:math/blas \
 		liblapack.so:math/lapack
 RUN_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}future>0:devel/py-future@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>0:science/py-scipy@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}nose>=0:devel/py-nose@${PY_FLAVOR}
 
 USES=		fortran gmake localbase:ldflags python shebangfix
-USE_PYTHON=	pep517 autoplist
+USE_PYTHON=	autoplist cython3 pep517
 
 TEST_TARGET=	test
 
 BINARY_ALIAS=	python2=${PYTHON_CMD}
 
 post-install:
 	${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/primme${PYTHON_EXT_SUFFIX}.so
 
 .include <bsd.port.mk>
diff --git a/math/py-pyFFTW/Makefile b/math/py-pyFFTW/Makefile
index eef5569bc99b..ac704b19d9be 100644
--- a/math/py-pyFFTW/Makefile
+++ b/math/py-pyFFTW/Makefile
@@ -1,35 +1,34 @@
 PORTNAME=	pyFFTW
 DISTVERSION=	0.15.0
 PORTREVISION=	1
 CATEGORIES=	math python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	${PORTNAME:tl}-${PORTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Pythonic wrapper around FFTW, the FFT library
 WWW=		https://hgomersall.github.io/pyFFTW/ \
 		https://github.com/pyFFTW/pyFFTW
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 PY_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}dask>=1.0.0:devel/py-dask@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=1.2.0:science/py-scipy@${PY_FLAVOR}
-BUILD_DEPENDS=	${PY_DEPENDS} \
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR}
+BUILD_DEPENDS=	${PY_DEPENDS}
 LIB_DEPENDS=	libfftw3.so:math/fftw3 \
 		libfftw3f.so:math/fftw3-float
 RUN_DEPENDS=	${PY_DEPENDS}
 
 USES=		python localbase:ldflags
-USE_PYTHON=	distutils cython autoplist pytest # tests fail with "attempted relative import with no known parent package", see https://github.com/pyFFTW/pyFFTW/issues/405
+USE_PYTHON=	autoplist cython3 distutils pytest # tests fail with "attempted relative import with no known parent package", see https://github.com/pyFFTW/pyFFTW/issues/405
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_WRKSRC=	${WRKSRC}/tests
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/pyfftw/pyfftw${PYTHON_EXT_SUFFIX}.so
 
 .include <bsd.port.mk>
diff --git a/math/py-pywavelets/Makefile b/math/py-pywavelets/Makefile
index 833b1c858022..5269db1a1593 100644
--- a/math/py-pywavelets/Makefile
+++ b/math/py-pywavelets/Makefile
@@ -1,27 +1,26 @@
 PORTNAME=	pywavelets
 PORTVERSION=	1.8.0
 CATEGORIES=	math python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	makc@FreeBSD.org
 COMMENT=	Discrete Wavelet Transforms in Python
 WWW=		https://github.com/PyWavelets/pywt
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYNUMPY} \
-		${PYTHON_PKGNAMEPREFIX}meson-python>=0.16:devel/meson-python@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}cython3>=3.0.4:lang/cython3@${PY_FLAVOR}
+		${PYTHON_PKGNAMEPREFIX}meson-python>=0.16:devel/meson-python@${PY_FLAVOR}
 RUN_DEPENDS=	${PYNUMPY}
 
 USES=		python:3.10+ shebangfix
-USE_PYTHON=	autoplist pep517
+USE_PYTHON=	autoplist cython3 pep517
 
 SHEBANG_FILES=	pywt/data/create_dat.py
 
 post-install:
 	${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/pywt/_extensions/*.so
 
 .include <bsd.port.mk>
diff --git a/math/py-slepc4py/Makefile b/math/py-slepc4py/Makefile
index a62a59e456fc..d16bab567fbb 100644
--- a/math/py-slepc4py/Makefile
+++ b/math/py-slepc4py/Makefile
@@ -1,34 +1,33 @@
 PORTNAME=	slepc4py
 DISTVERSION=	3.22.2
 PORTREVISION=	1
 CATEGORIES=	math python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	SLEPc for Python
 WWW=		https://bitbucket.org/slepc/slepc4py
 
 LICENSE=	BSD2CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.rst
 
 PY_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}petsc4py>0:math/py-petsc4py@${PY_FLAVOR}
-BUILD_DEPENDS=	${PY_DEPENDS} \
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3
+BUILD_DEPENDS=	${PY_DEPENDS}
 RUN_DEPENDS=	${PY_DEPENDS}
 LIB_DEPENDS=	libmpich.so:net/mpich \
 		libpetsc.so:science/PETSc \
 		libslepc.so:math/slepc
 RUN_DEPENDS=	${PYNUMPY}
 
 USES=		fortran python
-USE_PYTHON=	distutils autoplist pytest
+USE_PYTHON=	autoplist cython3 distutils pytest
 
 MAKE_ENV=	PETSC_DIR=${LOCALBASE} SLEPC_DIR=${LOCALBASE}
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/slepc4py/lib/SLEPc${PYTHON_EXT_SUFFIX}.so
 
 .include <bsd.port.mk>
diff --git a/math/py-yt/Makefile b/math/py-yt/Makefile
index 0fb3aca51a9c..bcd16ad88170 100644
--- a/math/py-yt/Makefile
+++ b/math/py-yt/Makefile
@@ -1,51 +1,49 @@
 PORTNAME=	yt
 DISTVERSION=	4.3.1
 PORTREVISION=	1
 CATEGORIES=	math astro python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Analysis and visualization toolkit for volumetric data
 WWW=		https://yt-project.org/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/COPYING.txt
 
 # dependencies are in setup.cfg
 BUILD_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}ewah-bool-utils>=1.0.2:devel/py-ewah-bool-utils@${PY_FLAVOR}
-BUILD_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3
-RUN_DEPENDS=	\
-		${PYNUMPY} \
+RUN_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}cmyt>=0.2.2:math/py-cmyt@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}ewah-bool-utils>=1.0.2:devel/py-ewah-bool-utils@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}ipywidgets>0:devel/py-ipywidgets@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}ipython>=1.0:devel/ipython@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}matplotlib>0:math/py-matplotlib@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}more-itertools>=8.4:devel/py-more-itertools@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}packaging>=20.9:devel/py-packaging@${PY_FLAVOR} \
 		${PY_PILLOW} \
 		${PYTHON_PKGNAMEPREFIX}pyparsing>=2.0.2:devel/py-pyparsing@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}sympy>=1.2:math/py-sympy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}toml>=0.10.2:textproc/py-toml@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tomli-w>=0.4.0:textproc/py-tomli-w@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tqdm>=3.4.0:misc/py-tqdm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}unyt>=2.8.0:math/py-unyt@${PY_FLAVOR}
 
 USES=		dos2unix localbase python
-USE_PYTHON=	distutils autoplist concurrent # cython, but cython3 isn't yet available
+USE_PYTHON=	autoplist concurrent cython3 distutils
 
 post-patch:
 	@${REINPLACE_CMD} -e "s|check_for_pyembree() is not None|False|" \
 		${WRKSRC}/setup.py
 	@${REINPLACE_CMD} -e "s|check_for_openmp() is True|True|" \
 		${WRKSRC}/setup.py
 	@${REINPLACE_CMD} -e "s|\['-fopenmp', filename\]|['-I${LOCALBASE}/include', '-L${LOCALBASE}/lib', '-lm', '-fopenmp', filename]|" \
 		${WRKSRC}/setupext.py
 
 post-install:
 	@${STRIP_CMD} $$(${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name "*.so")
 
 .include <bsd.port.mk>
diff --git a/net/py-mpi4py/Makefile b/net/py-mpi4py/Makefile
index f970a596ffdc..573f93fde519 100644
--- a/net/py-mpi4py/Makefile
+++ b/net/py-mpi4py/Makefile
@@ -1,56 +1,54 @@
 PORTNAME=	mpi4py
 DISTVERSION=	4.0.3
 PORTREVISION=	1
 CATEGORIES=	net parallel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	laurent.chardon@gmail.com
 COMMENT?=	Python bindings for MPI (OpenMPI)
 WWW=		https://github.com/mpi4py/mpi4py
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.rst
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>3.0.0:lang/cython3@${PY_FLAVOR}
-
 USES=		pkgconfig python
-USE_PYTHON=	autoplist concurrent distutils
+USE_PYTHON=	autoplist concurrent cython3 distutils
 
 MP?=			OPENMPI
 .if ${MP} == "OPENMPI"
 USES+=			mpi:openmpi
 CONFLICTS_INSTALL=	${PYTHON_PKGNAMEPREFIX}mpi4py-mpich-4*
 .elif ${MP} == "MPICH"
 USES+=			fortran mpi:mpich
 LDFLAGS+=		${LOCALBASE}/lib/gcc${GCC_DEFAULT}/libgcc_s.so
 CONFLICTS_INSTALL=	${PYTHON_PKGNAMEPREFIX}mpi4py-4*
 .else
 BROKEN=			invalid parameter MP
 .endif
 
 LDFLAGS+=	${MPI_LIBS}
 
 #SLAVEDIRS=	net/py-mpi4py-mpich
 
 OPTIONS_DEFINE=	DOCS
 
 PORTDOCS=	*
 
 pre-configure:
 	${CP} ${FILESDIR}/mpi.cfg ${WRKSRC}/
 	${REINPLACE_CMD} -e 's|%%LOCALBASE%%/mpi/openmpi|${MPI_HOME}|'	\
 		${WRKSRC}/mpi.cfg
 
 do-install-DOCS-on:
 	${MKDIR} ${STAGEDIR}${DOCSDIR}
 	${INSTALL_DATA} ${WRKSRC}/README.rst ${STAGEDIR}${DOCSDIR}
 	(cd ${WRKSRC}/docs && ${COPYTREE_SHARE} . ${STAGEDIR}${DOCSDIR})
 
 post-install:
 	(cd ${STAGEDIR}${PYTHON_SITELIBDIR}/mpi4py && ${STRIP_CMD} *.so)
 
 do-test:
 	(cd ${WRKSRC} && ${PYTHON_CMD} ${PYDISTUTILS_SETUP} test)
 
 .include <bsd.port.mk>
diff --git a/net/py-zeroconf/Makefile b/net/py-zeroconf/Makefile
index 0744ec068d2a..f0b47849bf8b 100644
--- a/net/py-zeroconf/Makefile
+++ b/net/py-zeroconf/Makefile
@@ -1,32 +1,31 @@
 PORTNAME=	zeroconf
 PORTVERSION=	0.132.2
 CATEGORIES=	net python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	jhixson@FreeBSD.org
 COMMENT=	Pure python implementation of multicast DNS service discovery
 WWW=		https://github.com/python-zeroconf/python-zeroconf
 
 LICENSE=	LGPL21+
 LICENSE_FILE=	${WRKSRC}/COPYING
 
 
-BUILD_DEPENDS=	lang/cython3>=3.0.8:lang/cython3 \
-		${PYTHON_PKGNAMEPREFIX}poetry-core>=1.5.2:devel/py-poetry-core@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}poetry-core>=1.5.2:devel/py-poetry-core@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=63.1.0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0.40.0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}async_timeout>=3.0.1:devel/py-async_timeout@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}ifaddr>=0.1.7:net/py-ifaddr@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pep8-naming>=0.12.0:devel/py-pep8-naming@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest>=8.0.0:devel/py-pytest@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest-asyncio>=0.20.3:devel/py-pytest-asyncio@${PY_FLAVOR}
 
 USES=		cpe python
-USE_PYTHON=	autoplist concurrent pep517 pytest
+USE_PYTHON=	autoplist concurrent cython3 pep517 pytest
 USE_GITHUB=	yes
 GH_ACCOUNT=	python-zeroconf
 GH_PROJECT=	python-zeroconf
 
 TEST_TARGET=	test
 
 .include <bsd.port.mk>
diff --git a/science/py-dimod/Makefile b/science/py-dimod/Makefile
index e6ff83ed6836..be947d42048c 100644
--- a/science/py-dimod/Makefile
+++ b/science/py-dimod/Makefile
@@ -1,33 +1,32 @@
 PORTNAME=	dimod
 DISTVERSION=	0.12.20
 CATEGORIES=	science python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	DWave: Shared API for QUBO/Ising samplers
 WWW=		https://github.com/dwavesystems/dimod
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYNUMPY} \
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR}
+BUILD_DEPENDS=	${PYNUMPY}
 RUN_DEPENDS=	${PYNUMPY}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}parameterized>0:devel/py-parameterized@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}mypy>0:devel/py-mypy@${PY_FLAVOR}
 
 USES=		compiler:c++11-lang python
-USE_PYTHON=	distutils autoplist unittest
+USE_PYTHON=	autoplist cython3 distutils unittest
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	dwavesystems
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_WRKSRC=	${WRKSRC}/tests
 
 post-install:
 	@${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR}/${PORTNAME} -name "*${PYTHON_EXT_SUFFIX}.so" | ${XARGS} ${STRIP_CMD}
 
 # tests as of 0.12.20: Ran 2913 tests in 34.742s
 
 .include <bsd.port.mk>
diff --git a/science/py-dipy/Makefile b/science/py-dipy/Makefile
index 39b110e8e9e9..a8cbaa735a49 100644
--- a/science/py-dipy/Makefile
+++ b/science/py-dipy/Makefile
@@ -1,50 +1,49 @@
 PORTNAME=	dipy
 DISTVERSION=	1.10.0
 CATEGORIES=	science python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python toolbox for analysis of MR diffusion imaging
 WWW=		https://dipy.org/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}meson-python>0:devel/meson-python@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}meson-python>0:devel/meson-python@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}h5py>=3.1.0:science/py-h5py@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}nibabel>=3.0.0:science/py-nibabel@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}packaging>=21:devel/py-packaging@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=1.8:science/py-scipy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tqdm>=4.30.0:misc/py-tqdm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}trx-python>=0.2.9:science/py-trx-python@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pandas>0:math/py-pandas@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scikit-learn>0:science/py-scikit-learn@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}statsmodels>0:math/py-statsmodels@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tables>0:devel/py-tables@${PY_FLAVOR} # "ml" extra dependencies, see dipy/info.py
 TEST_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}fury>0:graphics/py-fury@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}matplotlib>0:math/py-matplotlib@${PY_FLAVOR} # "viz" extra dependencies, see dipy/info.py
 TEST_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}cvxpy>0:math/py-cvxpy@${PY_FLAVOR} # "doc" extra dependencies, see dipy/info.py
 
 USES=		python shebangfix
-USE_PYTHON=	pep517 concurrent pytest # autoplist is broken: it produces incorrect entries and unnecessary files are also placed under doc/
+USE_PYTHON=	concurrent cython3 pep517 pytest # autoplist is broken: it produces incorrect entries and unnecessary files are also placed under doc/
 
 SHEBANG_GLOB=	*.sh *.py
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	# strip binaries
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/${PORTNAME}/*/*.so
 	# remove doc files
 	@${RM} -rf ${STAGEDIR}${PREFIX}/doc
 
 do-test:
 	cd ${WRKSRC} && ${SETENV} ${TEST_ENV} tools/ci/run_tests.sh
 
 .include <bsd.port.mk>
diff --git a/science/py-dwave-optimization/Makefile b/science/py-dwave-optimization/Makefile
index 67ae159ccff6..3b289fc324a8 100644
--- a/science/py-dwave-optimization/Makefile
+++ b/science/py-dwave-optimization/Makefile
@@ -1,43 +1,42 @@
 PORTNAME=	dwave-optimization
 DISTVERSION=	0.1.0
 CATEGORIES=	science python # quantum-computing
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	DWave: Nonlinear models for industrial optimization problems
 WWW=		https://github.com/dwavesystems/dwave-optimization
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
-		${PYNUMPY} \
+BUILD_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}setuptools-dso>=2.10:devel/py-setuptools-dso@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}reno>=4.1.0:textproc/py-reno@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	pep517 cython autoplist
+USE_PYTHON=	autoplist cython3 pep517
 
 POST_PLIST=	fix-plist
 
 post-install:
 	# strip binaries
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/optimization/libdwave-optimization.so \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/optimization/model${PYTHON_EXT_SUFFIX}.so \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/optimization/symbols${PYTHON_EXT_SUFFIX}.so
 	# remove conflicting __init__.py, see https://github.com/dwavesystems/dwave-system/issues/462
 	@${RM} -r \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/__init__.py \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/__pycache__
 
 fix-plist:
 	@${REINPLACE_CMD} -e " \
 		s|.*dwave/__init__\.py||; \
 		s|.*dwave/__pycache__/.*|| \
 		" ${TMPPLIST}
 
 .include <bsd.port.mk>
diff --git a/science/py-dwave-preprocessing/Makefile b/science/py-dwave-preprocessing/Makefile
index 072c327aa768..4f73fe34f2b9 100644
--- a/science/py-dwave-preprocessing/Makefile
+++ b/science/py-dwave-preprocessing/Makefile
@@ -1,38 +1,37 @@
 PORTNAME=	dwave-preprocessing
 DISTVERSION=	0.6.6
 PORTREVISION=	1
 CATEGORIES=	science python # quantum-computing
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	DWave: Preprocessing tools to aid in solving binary quadratic models
 WWW=		https://github.com/dwavesystems/dwave-preprocessing
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}dimod>=0.12.6:science/py-dimod@${PY_FLAVOR}
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}dimod>=0.12.6:science/py-dimod@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}dimod>=0.12.6:science/py-dimod@${PY_FLAVOR} \
 		${PYNUMPY}
 
 USES=		localbase:ldflags python
-USE_PYTHON=	distutils unittest # 1 test fails, see https://github.com/dwavesystems/dwave-preprocessing/issues/74
+USE_PYTHON=	cython3 distutils unittest # 1 test fails, see https://github.com/dwavesystems/dwave-preprocessing/issues/74
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	dwavesystems
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_WRKSRC=	${WRKSRC}/tests
 
 post-install:
 	# strip binaries
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/preprocessing/cyfix_variables${PYTHON_EXT_SUFFIX}.so \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/preprocessing/presolve/cypresolve${PYTHON_EXT_SUFFIX}.so
 	# remove conflicting __init__.py, see https://github.com/dwavesystems/dwave-preprocessing/issues/45
 	@${RM} -r \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/__init__.py \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/__pycache__
 
 .include <bsd.port.mk>
diff --git a/science/py-dwave-samplers/Makefile b/science/py-dwave-samplers/Makefile
index c4eb32c82672..1f613a7c0dd7 100644
--- a/science/py-dwave-samplers/Makefile
+++ b/science/py-dwave-samplers/Makefile
@@ -1,50 +1,49 @@
 PORTNAME=	dwave-samplers
 DISTVERSION=	1.3.0
 PORTREVISION=	1
 CATEGORIES=	science python # quantum-computing
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	DWave: Classical algorithms for solving binary quadratic models
 WWW=		https://github.com/dwavesystems/dwave-samplers
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 PY_DEPENDS=	${PYTHON_PKGNAMEPREFIX}dimod>=0.12.13:science/py-dimod@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}networkx>=2.6.3:math/py-networkx@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}reno>0:textproc/py-reno@${PY_FLAVOR}
-BUILD_DEPENDS=	${PY_DEPENDS} \
-		${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR}
+BUILD_DEPENDS=	${PY_DEPENDS}
 RUN_DEPENDS=	${PY_DEPENDS}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}parameterized>0:devel/py-parameterized@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	distutils unittest # 2 tests fail, see https://github.com/dwavesystems/dwave-samplers/issues/66
+USE_PYTHON=	cython3 distutils unittest # 2 tests fail, see https://github.com/dwavesystems/dwave-samplers/issues/66
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	dwavesystems
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_WRKSRC=	${WRKSRC}/tests
 
 post-install:
 	# fix file paths, workaround for https://github.com/dwavesystems/dwave-samplers/issues/31
 	@cd ${STAGEDIR}${PYTHON_SITELIBDIR} && ( \
 		for f in `${FIND} samplers -name "*.so"`; do \
 			${MV} $$f dwave/$$f; \
 		done; \
 		${RM} -r samplers; \
 	)
 	# strip binaries
 	@${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/samplers -name "*${PYTHON_EXT_SUFFIX}.so" | ${XARGS} ${STRIP_CMD}
 	# remove conflicting __init__.py, see https://github.com/dwavesystems/dwave-system/issues/462
 	@${RM} -r \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/__init__.py \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/__pycache__
 
 post-test:
 	@${SETENV} ${TEST_ENV} ${PYTHON_CMD} ${FILESDIR}/example.py
 
 .include <bsd.port.mk>
diff --git a/textproc/py-openstep-plist/Makefile b/textproc/py-openstep-plist/Makefile
index 0a46d703eab3..e35933298376 100644
--- a/textproc/py-openstep-plist/Makefile
+++ b/textproc/py-openstep-plist/Makefile
@@ -1,26 +1,25 @@
 PORTNAME=	openstep-plist
 PORTVERSION=	0.5.0
 CATEGORIES=	textproc python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	openstep_plist-${PORTVERSION}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	ASCII plist parser written in Cython
 WWW=		https://github.com/fonttools/openstep-plist
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>=0:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools-scm>=0:devel/py-setuptools-scm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	autoplist concurrent pep517
+USE_PYTHON=	autoplist concurrent cython3 pep517
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/www/py-wsaccel/Makefile b/www/py-wsaccel/Makefile
index 68ecb5d2032f..28e828757c80 100644
--- a/www/py-wsaccel/Makefile
+++ b/www/py-wsaccel/Makefile
@@ -1,34 +1,33 @@
 PORTNAME=	wsaccel
 DISTVERSION=	0.6.7
 PORTREVISION=	1
 CATEGORIES=	www python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	bofh@FreeBSD.org
 COMMENT=	WebSocket Accelerator for ws4py and AutobahnPython
 WWW=		https://github.com/methane/wsaccel
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 DEPRECATED=	Upstream ceased development
 
 BUILD_DEPENDS=	${PY_SETUPTOOLS} \
-	${PYTHON_PKGNAMEPREFIX}cython3>=3.0.11:lang/cython3@${PY_FLAVOR} \
-	${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
+		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	autoplist pep517 pytest
+USE_PYTHON=	autoplist cython3 pep517 pytest
 
 post-install:
 	${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/${PORTNAME}/utf8validator*.so
 	${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/${PORTNAME}/xormask*.so
 
 do-test:
 	@(cd ${TEST_WRKSRC} && ${SETENVI} ${WRK_ENV} ${TEST_ENV} pytest \
 		-k '${_PYTEST_FILTER_EXPRESSION}' \
 		-v -rs -o addopts= \
 		${PYTEST_ARGS})
 
 .include <bsd.port.mk>
diff --git a/www/py-yarl/Makefile b/www/py-yarl/Makefile
index 453e29e20dcb..62ee37761467 100644
--- a/www/py-yarl/Makefile
+++ b/www/py-yarl/Makefile
@@ -1,35 +1,34 @@
 PORTNAME=	yarl
 PORTVERSION=	1.18.3
 CATEGORIES=	www python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	amdmi3@FreeBSD.org
 COMMENT=	Yet another URL library
 WWW=		https://github.com/aio-libs/yarl
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>=3.0.11:lang/cython3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}expandvars>=0:devel/py-expandvars@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}expandvars>=0:devel/py-expandvars@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=47:devel/py-setuptools@${PY_FLAVOR} \
 		${PY_TOMLI} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}idna>=2.0:dns/py-idna@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}multidict>=4.0:www/py-multidict@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}propcache>=0.2.0:devel/py-propcache@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest-runner>0:devel/py-pytest-runner@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}hypothesis>0:devel/py-hypothesis@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-codspeed>0:devel/py-pytest-codspeed@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	autoplist pep517 pytest
+USE_PYTHON=	autoplist cython3 pep517 pytest
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/yarl/_quoting_c*.so
 
 pre-test:
 	@cd ${TEST_WRKSRC}/yarl && ${LN} -fs ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/yarl/_quoting_c*.so
 
 .include <bsd.port.mk>
diff --git a/x11/xpra/Makefile b/x11/xpra/Makefile
index 99fbb5232004..50e8a378cab4 100644
--- a/x11/xpra/Makefile
+++ b/x11/xpra/Makefile
@@ -1,122 +1,121 @@
 PORTNAME=	xpra
 PORTVERSION=	6.2.5
 CATEGORIES=	x11
 MASTER_SITES=	https://xpra.org/src/
 
 MAINTAINER=	arrowd@FreeBSD.org
 COMMENT=	Persistent remote applications for X
 WWW=		https://xpra.org/
 
 LICENSE=	GPLv2
 
-BUILD_DEPENDS=	pandoc:textproc/hs-pandoc \
-		cython-${PYTHON_VER}:lang/cython3@${PY_FLAVOR}
+BUILD_DEPENDS=	pandoc:textproc/hs-pandoc
 LIB_DEPENDS=	libavcodec.so:multimedia/ffmpeg \
 		libbrotlidec.so:archivers/brotli \
 		libdrm.so:graphics/libdrm \
 		libharfbuzz.so:print/harfbuzz \
 		liblz4.so:archivers/liblz4 \
 		libopenh264.so:multimedia/openh264 \
 		libwebp.so:graphics/webp \
 		libx264.so:multimedia/libx264 \
 		libxxhash.so:devel/xxhash
 RUN_DEPENDS=	${PY_PILLOW} \
 		${PYTHON_PKGNAMEPREFIX}bencode.py>1:converters/py-bencode.py@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}brotli>1:archivers/py-brotli@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}dbus>1:devel/py-dbus@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}lz4>=0.7.0_1:archivers/py-lz4@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}netifaces>0:net/py-netifaces@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}paramiko>0:security/py-paramiko@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pyinotify>0:devel/py-pyinotify@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}PyOpenGL-accelerate>=3.1.0:graphics/py-PyOpenGL-accelerate@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}PyOpenGL>=3.1.0:graphics/py-PyOpenGL@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}rencode>1:converters/py-rencode@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}xdg>0:devel/py-xdg@${PY_FLAVOR} \
 		setxkbmap:x11/setxkbmap \
 		ssh-askpass:security/openssh-askpass \
 		xauth:x11/xauth \
 		xkbcomp:x11/xkbcomp \
 		Xvfb:x11-servers/xorg-server@xvfb
 
 USES=		desktop-file-utils gettext-runtime gnome localbase pkgconfig \
 		python shared-mime-info shebangfix tar:xz xorg
 
 USE_GNOME=	cairo gdkpixbuf gtk30 pygobject3
-USE_PYTHON=	cryptography distutils noflavors
+USE_PYTHON=	cryptography cython3 distutils noflavors
 USE_XORG=	x11 xcomposite xdamage xext xfixes xi xkbfile xrandr xres xtst
 PLIST_SUB+=	PORTVERSION=${PORTVERSION} \
 		PYTHON_SUFFIX=${PYTHON_SUFFIX} \
 		PYTHON_VER=${PYTHON_VER}
 SHEBANG_FILES=	fs/lib/cups/backend/xpraforwarder fs/libexec/xpra/auth_dialog \
 		fs/libexec/xpra/gnome-open fs/libexec/xpra/gvfs-open \
 		fs/libexec/xpra/xdg-open fs/libexec/xpra/xpra_signal_listener \
 		fs/libexec/xpra/xpra_udev_product_version
 
 OPTIONS_DEFINE=		AVAHI CUPS DOCS GSTREAMER LIBYUV \
 			WEBCAM
 OPTIONS_DEFAULT=	AVAHI CUPS GSTREAMER
 OPTIONS_SUB=		yes
 
 AVCODEC_DESC=	Enable avcodec2 (FFmpeg) decoder
 CUPS_DESC=	Enable CUPS for printer forwarding
 FFMPEG_DESC=	Enable FFmpeg encoder
 GSTREAMER_DESC=	Enable GStreamer for sound forwarding
 LIBYUV_DESC=	Enable libyuv CSC module (fastest)
 WEBCAM_DESC=	Enable webcam forwarding (client only)
 
 AVAHI_RUN_DEPENDS=		${PYTHON_PKGNAMEPREFIX}avahi>0:net/py-avahi@${PY_FLAVOR}
 AVAHI_VARS=			XPRA_OPTIONS+=mdns
 CUPS_RUN_DEPENDS=		${PYTHON_PKGNAMEPREFIX}pycups>1:print/py-pycups@${PY_FLAVOR}
 CUPS_VARS=			XPRA_OPTIONS+=printing
 GSTREAMER_USES=			gstreamer
 GSTREAMER_BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}gstreamer1>1:multimedia/py-gstreamer1@${PY_FLAVOR}
 GSTREAMER_RUN_DEPENDS=		${PYTHON_PKGNAMEPREFIX}gstreamer1>1:multimedia/py-gstreamer1@${PY_FLAVOR}
 GSTREAMER_USE=			GSTREAMER=flac,lame,mpg123,ogg,opus,pulse,vorbis,wavpack
 GSTREAMER_VARS=			XPRA_OPTIONS+=gstreamer
 LIBYUV_LIB_DEPENDS=		libyuv.so:graphics/libyuv
 LIBYUV_VARS=			XPRA_OPTIONS+=csc_libyuv
 WEBCAM_RUN_DEPENDS=		opencv>2:graphics/opencv
 WEBCAM_VARS=			XPRA_OPTIONS+=webcam
 
 PYDISTUTILS_PKGNAME=	xpra_all
 XPRA_OPTIONS_ALL+=	${XPRA_OPTIONS_DISABLED} csc_libyuv \
 			enc_x264 \
 			mdns printing vpx webcam
 XPRA_OPTIONS=		dec_avcodec2 enc_ffmpeg enc_x264
 XPRA_OPTIONS_DISABLED=	pam strict uinput vpx Xdummy Xdummy_wrapper
 
 .include <bsd.port.options.mk>
 
 .for opt in ${XPRA_OPTIONS_ALL}
 .if empty(XPRA_OPTIONS:M${opt})
 PYDISTUTILS_ARGS+=	--without-${opt}
 .else
 PYDISTUTILS_ARGS+=	--with-${opt}
 .endif
 .endfor
 
 .include <bsd.port.pre.mk>
 
 PYDISTUTILS_BUILDARGS+=	${PYDISTUTILS_ARGS}
 PYDISTUTILS_CONFIGUREARGS+=	${PYDISTUTILS_ARGS}
 PYDISTUTILS_INSTALLARGS+=	${PYDISTUTILS_ARGS}
 #MAKE_ENV=	pkgdir=${STAGEDIR}${PREFIX}/
 
 post-patch:
 	@${REINPLACE_CMD} -e 's|/usr/share|${LOCALBASE}/share|' \
 	    ${WRKSRC}/xpra/platform/pycups_printing.py
 	@${REINPLACE_CMD} -e 's|/usr/sbin|${LOCALBASE}/sbin|' \
 	    ${WRKSRC}/fs/etc/xpra/conf.d/16_printing.conf.in
 
 post-install:
 	${MKDIR} ${STAGEDIR}${ETCDIR}
 	${CP} -r ${STAGEDIR}/etc ${STAGEDIR}${PREFIX} && ${RM} -r ${STAGEDIR}/etc
 	${MV} ${STAGEDIR}${ETCDIR}/xorg.conf \
 	    ${STAGEDIR}${ETCDIR}/xorg.conf.sample
 	${MV} ${STAGEDIR}${ETCDIR}/xpra.conf \
 	    ${STAGEDIR}${ETCDIR}/xpra.conf.sample
 	${CP} -r ${STAGEDIR}${PREFIX}/etc/dbus-1 ${STAGEDIR}${PREFIX}/share && ${RM} -r ${STAGEDIR}${PREFIX}/dbus-1
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR}/${PORTNAME} -name '*.so' \
 	    -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.post.mk>