diff --git a/math/py-rpy2/Makefile b/math/py-rpy2/Makefile
index d1390692f5a3..7033aaf66028 100644
--- a/math/py-rpy2/Makefile
+++ b/math/py-rpy2/Makefile
@@ -1,46 +1,51 @@
 # Created by: ijliao
 
 PORTNAME=	rpy2
-PORTVERSION=	3.4.5
-PORTREVISION=	2
+PORTVERSION=	3.5.0
 CATEGORIES=	math python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python interface to the R Programming Language
 
 LICENSE=	GPLv2+
 LICENSE_FILE=	${WRKSRC}/gpl-2.0.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.10.0:devel/py-cffi@${PY_FLAVOR}
 LIB_DEPENDS=	libR.so:math/R \
 		libicui18n.so:devel/icu \
 		libpcre.so:devel/pcre
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.10.0:devel/py-cffi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}Jinja2>=0:devel/py-Jinja2@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytz>=0,1,1:devel/py-pytz@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tzlocal>=0:devel/py-tzlocal@${PY_FLAVOR}
 
 USES=		compiler:c11 fortran python:3.7+ readline
 USE_PYTHON=	autoplist concurrent distutils
 
 MAKE_ENV=	RPY2_CFFI_MODE=BOTH
 
 PLIST_FILES=	${PYTHON_SITELIBDIR}/__pycache__/_rinterface_cffi_abi.cpython-${PYTHON_SUFFIX}.opt-1.pyc \
 		${PYTHON_SITELIBDIR}/__pycache__/_rinterface_cffi_abi.cpython-${PYTHON_SUFFIX}.pyc \
 		${PYTHON_SITELIBDIR}/_rinterface_cffi_abi.py
 
 OPTIONS_DEFINE=	NUMPY PANDAS
 OPTIONS_DEFAULT=NUMPY PANDAS
 NUMPY_DESC=	Numpy support
 PANDAS_DESC=	Pandas support
 
 NUMPY_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pandas>=0,1:math/py-pandas@${PY_FLAVOR}
 PANDAS_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}pandas>=0,1:math/py-pandas@${PY_FLAVOR}
 
+.include <bsd.port.pre.mk>
+
+.if ${PYTHON_REL} < 30800
+RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}typing-extensions>=0:devel/py-typing-extensions@${PY_FLAVOR}
+.endif
+
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
-.include <bsd.port.mk>
+.include <bsd.port.post.mk>
diff --git a/math/py-rpy2/distinfo b/math/py-rpy2/distinfo
index 1326cceabd04..6e6c4ca3fc68 100644
--- a/math/py-rpy2/distinfo
+++ b/math/py-rpy2/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1622214106
-SHA256 (rpy2-3.4.5.tar.gz) = 5d31a5ea43f5a59f6dec30faca87edb01fc9b8affa0beae96a99be923bd7dab3
-SIZE (rpy2-3.4.5.tar.gz) = 194433
+TIMESTAMP = 1649423822
+SHA256 (rpy2-3.5.0.tar.gz) = 4d8a20253320ae3e402ec20d56640772bdc27731bd14f7d0475a95d86e7cd1c7
+SIZE (rpy2-3.5.0.tar.gz) = 201597