diff --git a/biology/minimap2/Makefile b/biology/minimap2/Makefile
index 4f479b8f908c..3dca063831be 100644
--- a/biology/minimap2/Makefile
+++ b/biology/minimap2/Makefile
@@ -1,30 +1,33 @@
 PORTNAME=		minimap2
 DISTVERSIONPREFIX=	v
 DISTVERSION=		2.28
 PORTREVISION=		1
 CATEGORIES=		biology
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Pairwise aligner for genomic and spliced nucleotide sequences
 WWW=		https://github.com/lh3/minimap2
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
+NOT_FOR_ARCHS=		i386 mips powerpc powerpcspe
+NOT_FOR_ARCHS_REASON=	Requires 64-bit processor, except ARM NEON
+
 BUILD_DEPENDS=	simde>0:devel/simde
 
 USES=		gmake localbase
 USE_GITHUB=	yes
 
 GH_ACCOUNT=	lh3
 
 ALL_TARGET=	extra
 INSTALL_TARGET=	install-strip
 
 MAKEFILE=	Makefile.simde
 MAKE_ARGS=	MAN1DIR=${PREFIX}/share/man/man1
 
 pre-build:
 	${REINPLACE_CMD} -e 's|-msse4.1||g' -e 's|-msse2||g' ${WRKSRC}/Makefile.simde
 
 .include <bsd.port.mk>