diff --git a/science/py-eccodes/Makefile b/science/py-eccodes/Makefile
index 5f7093dce593..044eb813edc2 100644
--- a/science/py-eccodes/Makefile
+++ b/science/py-eccodes/Makefile
@@ -1,31 +1,31 @@
 PORTNAME=	eccodes
-PORTVERSION=	2.42.0
+PORTVERSION=	2.43.0
 CATEGORIES=	science python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python interface to the ecCodes BUFR and GRIB de/encoder
 WWW=		https://github.com/ecmwf/eccodes-python
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libeccodes.so:science/eccodes
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}attrs>=0:devel/py-attrs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}cffi>=0:devel/py-cffi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}findlibs>=0:devel/py-findlibs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest>=0:devel/py-pytest@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-cov>=0:devel/py-pytest-cov@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-flakes>=0:devel/py-pytest-flakes@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}typing-extensions>=0:devel/py-typing-extensions@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	autoplist concurrent pep517 pytest
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/science/py-eccodes/distinfo b/science/py-eccodes/distinfo
index 21954c2072d6..e37fc89abc25 100644
--- a/science/py-eccodes/distinfo
+++ b/science/py-eccodes/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1750954222
-SHA256 (eccodes-2.42.0.tar.gz) = 0abb2bc6c6f4e83749c4e9c313d5428c62b15dc6c5b47d2807943e3a5ffd5291
-SIZE (eccodes-2.42.0.tar.gz) = 2268756
+TIMESTAMP = 1753796092
+SHA256 (eccodes-2.43.0.tar.gz) = b99c41aaa64b20291452297a3d513e0b08cc96bcedfe364d8f58348159c48faa
+SIZE (eccodes-2.43.0.tar.gz) = 2269307
diff --git a/science/py-eccodes/files/patch-setup.py b/science/py-eccodes/files/patch-setup.py
new file mode 100644
index 000000000000..8a15aeac70e2
--- /dev/null
+++ b/science/py-eccodes/files/patch-setup.py
@@ -0,0 +1,10 @@
+--- setup.py.orig	2025-07-25 10:03:25 UTC
++++ setup.py
+@@ -90,7 +90,6 @@ install_requires += [
+     "attrs",
+     "cffi",
+     "findlibs",
+-    "eccodeslib;platform_system!='Windows'",
+ ]
+ 
+ setuptools.setup(