diff --git a/misc/py-openvdb/Makefile b/misc/py-openvdb/Makefile
index 545b34619b0f..1caafc26d9be 100644
--- a/misc/py-openvdb/Makefile
+++ b/misc/py-openvdb/Makefile
@@ -1,45 +1,46 @@
 PORTNAME=	openvdb
 DISTVERSIONPREFIX=	v
-DISTVERSION=	11.0.0
-PORTREVISION=	6
+DISTVERSION=	12.0.1
 CATEGORIES=	misc
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Tools for storage and manipulation of sparse volumetric data
-WWW=		https://www.openvdb.org/
+WWW=		https://www.openvdb.org \
+		https://github.com/AcademySoftwareFoundation/openvdb
 
 LICENSE=	MPL20
 LICENSE_FILE=	${WRKSRC}/../../../LICENSE
 
-BUILD_DEPENDS=	pybind11>0:devel/pybind11 \
+BUILD_DEPENDS=	nanobind>0:devel/nanobind \
 		${PYNUMPY}
 LIB_DEPENDS=	libboost_iostreams.so:devel/boost-libs \
 		libopenvdb.so:misc/openvdb \
 		libtbb.so:devel/onetbb
 RUN_DEPENDS=	${PYNUMPY}
 
 USES=		cmake compiler:c++17-lang localbase:ldflags python
 USE_LDCONFIG=	yes
 USE_PYTHON=	flavors pytest
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	AcademySoftwareFoundation
 
 CMAKE_ON=	USE_NUMPY OPENVDB_PYTHON_WRAP_ALL_GRID_TYPES
 CMAKE_OFF=	OPENVDB_BUILD_PYTHON_UNITTESTS
-CMAKE_ARGS=	-DPython_EXECUTABLE=${PYTHON_CMD}
+CMAKE_ARGS=	-DPython_EXECUTABLE=${PYTHON_CMD} \
+		-DFREEBSD_PYTHON_VER=${PYTHON_VER}
 
 WRKSRC_SUBDIR=	openvdb/openvdb/python
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
-PLIST_FILES=	${PYTHON_SITELIBDIR}/pyopenvdb${PYTHON_EXT_SUFFIX}.so
+PLIST_FILES=	${PYTHON_SITELIBDIR}/openvdb${PYTHON_EXT_SUFFIX}.so
 
 do-test: # run an example, since the supplied test appears to be only for Windows
 	@cd ${WRKSRC} && \
 		${SETENV} ${TEST_ENV} ${PYTHON_CMD} ${FILESDIR}/example.py && \
 		[ -f ${WRKSRC}/mygrids.vdb ] && \
 		${ECHO} "Test has succeeded."
 
 .include <bsd.port.mk>
diff --git a/misc/py-openvdb/distinfo b/misc/py-openvdb/distinfo
index a13ad98f22cf..54699eb6d329 100644
--- a/misc/py-openvdb/distinfo
+++ b/misc/py-openvdb/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1712017184
-SHA256 (AcademySoftwareFoundation-openvdb-v11.0.0_GH0.tar.gz) = 6314ff1db057ea90050763e7b7d7ed86d8224fcd42a82cdbb9c515e001b96c74
-SIZE (AcademySoftwareFoundation-openvdb-v11.0.0_GH0.tar.gz) = 4620858
+TIMESTAMP = 1743748486
+SHA256 (AcademySoftwareFoundation-openvdb-v12.0.1_GH0.tar.gz) = a3c8724ecadabaf558b6e1bd6f1d695e93b82a7cfdf144b8551e5253340ddce0
+SIZE (AcademySoftwareFoundation-openvdb-v12.0.1_GH0.tar.gz) = 4708771
diff --git a/misc/py-openvdb/files/example.py b/misc/py-openvdb/files/example.py
index 7535f81dfb90..73436ebe8f38 100644
--- a/misc/py-openvdb/files/example.py
+++ b/misc/py-openvdb/files/example.py
@@ -1,33 +1,33 @@
 # example from https://www.openvdb.org/documentation/doxygen/python.html
 
-import pyopenvdb as vdb
+import openvdb as vdb
 
 # A grid comprises a sparse tree representation of voxel data,
 # user-supplied metadata and a voxel space to world space transform,
 # which defaults to the identity transform.
 # A FloatGrid stores one single-precision floating point value per voxel.
 # Other grid types include BoolGrid and Vec3SGrid.  The module-level
 # attribute pyopenvdb.GridTypes gives the complete list.
 cube = vdb.FloatGrid()
 cube.fill(min=(100, 100, 100), max=(199, 199, 199), value=1.0)
 
 # Name the grid "cube".
 cube.name = 'cube'
 
 # Populate another FloatGrid with a sparse, narrow-band level set
 # representation of a sphere with radius 50 voxels, located at
 # (1.5, 2, 3) in index space.
 sphere = vdb.createLevelSetSphere(radius=50, center=(1.5, 2, 3))
 
 # Associate some metadata with the grid.
 sphere['radius'] = 50.0
 
 # Associate a scaling transform with the grid that sets the voxel size
 # to 0.5 units in world space.
 sphere.transform = vdb.createLinearTransform(voxelSize=0.5)
 
 # Name the grid "sphere".
 sphere.name = 'sphere'
 
 # Write both grids to a VDB file.
 vdb.write('mygrids.vdb', grids=[cube, sphere])
diff --git a/misc/py-openvdb/files/patch-CMakeLists.txt b/misc/py-openvdb/files/patch-CMakeLists.txt
index 89826f5b5501..1ad94f363c20 100644
--- a/misc/py-openvdb/files/patch-CMakeLists.txt
+++ b/misc/py-openvdb/files/patch-CMakeLists.txt
@@ -1,12 +1,19 @@
---- CMakeLists.txt.orig	2022-10-27 23:35:20 UTC
+--- CMakeLists.txt.orig	2025-04-03 05:22:14 UTC
 +++ CMakeLists.txt
-@@ -12,6 +12,9 @@ project(OpenVDBPython LANGUAGES CXX)
+@@ -12,6 +12,16 @@ include(GNUInstallDirs)
  
  include(GNUInstallDirs)
  
 +set(CMAKE_MODULE_PATH "${CMAKE_INSTALL_PREFIX}/lib/cmake/OpenVDB" ${CMAKE_MODULE_PATH})
 +find_package(OpenVDB REQUIRED)
++find_package(Python ${FREEBSD_PYTHON_VER} EXACT REQUIRED COMPONENTS Development Interpreter)
++find_package(nanobind REQUIRED)
++set(Python_PACKAGES_DIR "site-packages")
++set(VDB_PYTHON_INSTALL_DIRECTORY
++  ${CMAKE_INSTALL_LIBDIR}/python${Python_VERSION_MAJOR}.${Python_VERSION_MINOR}/${Python_PACKAGES_DIR}
++  CACHE STRING "The directory to install the openvdb and nanovdb Python modules."
++)
 +
  ###### OpenVDB Python Options
  
  option(USE_NUMPY "Build the python library with numpy support." OFF)