diff --git a/devel/py-pyquil/Makefile b/devel/py-pyquil/Makefile
index ca5f1ab7ce13..cd863bad57ec 100644
--- a/devel/py-pyquil/Makefile
+++ b/devel/py-pyquil/Makefile
@@ -1,34 +1,34 @@
 PORTNAME=	pyquil
-DISTVERSION=	4.5.0
+DISTVERSION=	4.6.1
 CATEGORIES=	devel python # quantum-computing
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	PyQuil: Quantum programming in Python
 WWW=		https://github.com/rigetti/pyquil
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}poetry-core>=1.0.0:devel/py-poetry-core@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}lark>=0.11.1:devel/py-lark@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}networkx>=2.5:math/py-networkx@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}packaging>=23.1<24.0:devel/py-packaging@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pydantic>=1.10.7:devel/py-pydantic@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}qcs-sdk-python>=0.16.3:devel/py-qcs-sdk-python@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}retry2>=0.9.2,<0.10.0:devel/py-retry2@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}rpcq>=3.10.0<4.0.0:devel/py-rpcq@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=1.7.3<2.0.0:science/py-scipy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tenacity>=8.2.2<9.0.0:devel/py-tenacity@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}types-python-dateutil>=2.8.19:devel/py-types-python-dateutil@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}types-retry>=0.9.9<1.0.0:devel/py-types-retry@${PY_FLAVOR} \
 		quilc:lang/quilc
 
 USES=		python
 USE_PYTHON=	pep517 autoplist
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/devel/py-pyquil/distinfo b/devel/py-pyquil/distinfo
index e954b46cc6bf..e9821ca31553 100644
--- a/devel/py-pyquil/distinfo
+++ b/devel/py-pyquil/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1706300868
-SHA256 (pyquil-4.5.0.tar.gz) = b4e125d2712df70a3cd0d6af3b4ed043f026744ea5f2a46d460d35e2ca657ab0
-SIZE (pyquil-4.5.0.tar.gz) = 163317
+TIMESTAMP = 1707202360
+SHA256 (pyquil-4.6.1.tar.gz) = 508d23bc2bc88c2b5a0e4f29e7ae9e0307d61c6cdab34b1bd342404d30fdf56c
+SIZE (pyquil-4.6.1.tar.gz) = 164140