diff --git a/devel/py-mystic/Makefile b/devel/py-mystic/Makefile
index bfe064d56bfc..e92d35a0c969 100644
--- a/devel/py-mystic/Makefile
+++ b/devel/py-mystic/Makefile
@@ -1,28 +1,28 @@
 PORTNAME=	mystic
-PORTVERSION=	0.4.0
-PORTREVISION=	1
+PORTVERSION=	0.4.1
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Highly-constrained non-convex optimization and uncertainty quantification
-WWW=		https://github.com/uqfoundation/mystic
+WWW=		https://mystic.readthedocs.io/en/latest/ \
+		https://github.com/uqfoundation/mystic
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PY_SETUPTOOLS} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=42:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}dill>=0.3.6:devel/py-dill@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}klepto>=0.2.3:devel/py-klepto@${PY_FLAVOR} \
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}dill>=0.3.7:devel/py-dill@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}klepto>=0.2.4:devel/py-klepto@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}mpmath>=0.19:math/py-mpmath@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}numpy>=1.0,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}sympy>=0.6.7:math/py-sympy@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	autoplist concurrent cython pep517
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/devel/py-mystic/distinfo b/devel/py-mystic/distinfo
index 84eec4c609fb..cbeea82e5d16 100644
--- a/devel/py-mystic/distinfo
+++ b/devel/py-mystic/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1681052886
-SHA256 (mystic-0.4.0.tar.gz) = 04027c856f776b1724b18deab9dd222f0602c20b54dbaadbff7a255006cfadce
-SIZE (mystic-0.4.0.tar.gz) = 556775
+TIMESTAMP = 1691070076
+SHA256 (mystic-0.4.1.tar.gz) = e758d02724bb57bcdf444366ebf5087c280ff3ed772fde40b92e43c805ac889d
+SIZE (mystic-0.4.1.tar.gz) = 577397