diff --git a/biology/py-pywgsim/Makefile b/biology/py-pywgsim/Makefile
index fd78a49e253d..51411e77ee7f 100644
--- a/biology/py-pywgsim/Makefile
+++ b/biology/py-pywgsim/Makefile
@@ -1,22 +1,23 @@
 PORTNAME=	pywgsim
-DISTVERSION=	0.5.2
-PORTREVISION=	2
+DISTVERSION=	0.6.0
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Modified wgsim genomic data simulator
 WWW=		https://github.com/ialbert/pywgsim/
 
 LICENSE=	MIT
 
+BUILD_DEPENDS=	${PY_SETUPTOOLS} \
+		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}plac>=0:devel/py-plac@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	autoplist cython distutils
+USE_PYTHON=	autoplist pep517
 
-post-configure:
-	cython-${PYTHON_VER} ${WRKSRC}/pywgsim/wgsim_lib.pyx
+post-stage:
+	${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/pywgsim/*.so
 
 .include <bsd.port.mk>
diff --git a/biology/py-pywgsim/distinfo b/biology/py-pywgsim/distinfo
index a139ccb217c0..c73579806e5a 100644
--- a/biology/py-pywgsim/distinfo
+++ b/biology/py-pywgsim/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1630888272
-SHA256 (pywgsim-0.5.2.tar.gz) = b6726be21629bd1cda12592b536dcd62d250fc4872e47cbcc54066e8a6e8f709
-SIZE (pywgsim-0.5.2.tar.gz) = 81724
+TIMESTAMP = 1787830209
+SHA256 (pywgsim-0.6.0.tar.gz) = 863f2de8e989dbcd667b01c5d3d8f82f9762c1086928016c467f9743dfa3f82f
+SIZE (pywgsim-0.6.0.tar.gz) = 117571