diff --git a/devel/py-anndata/Makefile b/devel/py-anndata/Makefile
index 5fe91ff56d92..59bd0cfeaa2c 100644
--- a/devel/py-anndata/Makefile
+++ b/devel/py-anndata/Makefile
@@ -1,37 +1,36 @@
 PORTNAME=	anndata
-PORTVERSION=	0.10.5
-DISTVERSIONSUFFIX=	.post1
+PORTVERSION=	0.10.6
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Annotated data
 WWW=		https://anndata.readthedocs.io/en/latest/ \
 		https://github.com/scverse/anndata
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}hatch-vcs>=0:devel/py-hatch-vcs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}hatchling>=0:devel/py-hatchling@${PY_FLAVOR}
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}array-api-compat>=0:devel/py-array-api-compat@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}h5py>=3:science/py-h5py@${PY_FLAVOR} \
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}array-api-compat>=1.4:devel/py-array-api-compat@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}h5py>=3.1:science/py-h5py@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}natsort>=0:devel/py-natsort@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}numpy>=1.16.5,1:math/py-numpy@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}packaging>=20:devel/py-packaging@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}pandas>=1.1.1,1:math/py-pandas@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}scipy>=1.4:science/py-scipy@${PY_FLAVOR}
+		${PYTHON_PKGNAMEPREFIX}numpy>=1.23,1:math/py-numpy@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}packaging>=20.0:devel/py-packaging@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}pandas>=1.4,1:math/py-pandas@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}scipy>=1.8:science/py-scipy@${PY_FLAVOR}
 
 USES=		python:3.9+
 USE_PYTHON=	autoplist concurrent pep517
 
 NO_ARCH=	yes
 
 .include <bsd.port.pre.mk>
 
 .if ${PYTHON_REL} < 31100
 RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}exceptiongroup>=0:devel/py-exceptiongroup@${PY_FLAVOR}
 .endif
 
 .include <bsd.port.post.mk>
diff --git a/devel/py-anndata/distinfo b/devel/py-anndata/distinfo
index 698251de71a2..db43e47d7390 100644
--- a/devel/py-anndata/distinfo
+++ b/devel/py-anndata/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1708449122
-SHA256 (anndata-0.10.5.post1.tar.gz) = 9a17c6eda9fc40759b3f5f81742f5d18c1a0a1acdf02f13e1646700ec082c155
-SIZE (anndata-0.10.5.post1.tar.gz) = 163852
+TIMESTAMP = 1712084484
+SHA256 (anndata-0.10.6.tar.gz) = 16ada7ed7d38552ce56d8e8b2348e18a5fc81294ce8a7ea282acf30dc42cd6c2
+SIZE (anndata-0.10.6.tar.gz) = 166396