diff --git a/science/py-pynwb/Makefile b/science/py-pynwb/Makefile
index ae0c7fc66a59..9d0840146a51 100644
--- a/science/py-pynwb/Makefile
+++ b/science/py-pynwb/Makefile
@@ -1,43 +1,43 @@
 PORTNAME=	pynwb
-DISTVERSION=	4.1.0
+DISTVERSION=	4.2.0
 CATEGORIES=	science python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Package for working with Neurodata stored in the NWB format
 WWW=		https://github.com/NeurodataWithoutBorders/pynwb
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/license.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}hatch-vcs>=0:devel/py-hatch-vcs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}hatchling>=0:devel/py-hatchling@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}h5py>=3.6.0:science/py-h5py@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}hdmf>=6.1.0:science/py-hdmf@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}hdmf>=6.2.0:science/py-hdmf@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}numpy>=1.24.0:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pandas>=1.4.0:math/py-pandas@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}platformdirs>=4.2.2:devel/py-platformdirs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}python-dateutil>=2.8.2:devel/py-python-dateutil@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest-cov>=0:devel/py-pytest-cov@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	pep517 concurrent autoplist pytest
 
 TEST_ENV=	${MAKE_ENV} PATH=${STAGEDIR}${PREFIX}/bin:${PATH} \
 		PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_ARGS=	-o "testpaths=tests"
 PYTEST_BROKEN_TESTS=	create_test_extension \
 			test_custom_target_table \
 			test_get_class \
 			test_load_namespace_with_reftype_attribute_check_autoclass_const \
 			test_available_namespaces
 
 NO_ARCH=	yes
 
 post-extract:
 	@${RM} -r ${WRKSRC}/tests/read_dandi
 
-# tests as of 4.1.0: 826 passed, 11 skipped, 4 deselected in 127.02s
+# tests as of 4.2.0: 874 passed, 15 skipped, 4 deselected in 152.55s
 
 .include <bsd.port.mk>
diff --git a/science/py-pynwb/distinfo b/science/py-pynwb/distinfo
index 9726c2e9753f..57f12099487e 100644
--- a/science/py-pynwb/distinfo
+++ b/science/py-pynwb/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1785188114
-SHA256 (pynwb-4.1.0.tar.gz) = 2d2672ba467826e61b14d9518866e75b6d2925ddc23c30672309bf7644ea0ed0
-SIZE (pynwb-4.1.0.tar.gz) = 36407506
+TIMESTAMP = 1788793951
+SHA256 (pynwb-4.2.0.tar.gz) = 681e86b73cf21fc607003936ac9e575efdb64d3d01001bfa351862d40f9b5e7e
+SIZE (pynwb-4.2.0.tar.gz) = 36416898