diff --git a/science/py-pyteomics/Makefile b/science/py-pyteomics/Makefile
index b484a2c4d71a..d70a933d9993 100644
--- a/science/py-pyteomics/Makefile
+++ b/science/py-pyteomics/Makefile
@@ -1,33 +1,33 @@
 PORTNAME=	pyteomics
-PORTVERSION=	4.5.2
+PORTVERSION=	4.5.3
 CATEGORIES=	science python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python modules for proteomics data analysis
 
 LICENSE=	APACHE20
 
 USES=		python:3.7+
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
 
 OPTIONS_DEFINE=	DF GRAPHICS TDA UNIMOD XML
 OPTIONS_DEFAULT=DF GRAPHICS TDA UNIMOD XML
 DF_DESC=	DataFrame support
 GRAPHICS_DESC=	Graphics support
 TDA_DESC=	Target-decoy approach support
 UNIMOD_DESC=	Unimod database support
 XML_DESC=	XML support
 
 DF_RUN_DEPENDS=		${PYTHON_PKGNAMEPREFIX}pandas>=0,1:math/py-pandas@${PY_FLAVOR}
 GRAPHICS_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}matplotlib>=0:math/py-matplotlib@${PY_FLAVOR}
 TDA_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR}
 UNIMOD_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}lxml>=0:devel/py-lxml@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}sqlalchemy14>=0:databases/py-sqlalchemy14@${PY_FLAVOR}
 XML_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}lxml>=0:devel/py-lxml@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR}
 
 .include <bsd.port.mk>
diff --git a/science/py-pyteomics/distinfo b/science/py-pyteomics/distinfo
index ae98c8c97f97..ac9ead271119 100644
--- a/science/py-pyteomics/distinfo
+++ b/science/py-pyteomics/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1643971124
-SHA256 (pyteomics-4.5.2.tar.gz) = 111bac1d553a42f3d704fa479963593e57986da729e4b57332374e32488d2ede
-SIZE (pyteomics-4.5.2.tar.gz) = 199978
+TIMESTAMP = 1647264664
+SHA256 (pyteomics-4.5.3.tar.gz) = 066528ef9a0b2a0eb2f47beb3e2a7e920f91f464e7397b058a5fa2a8482d175b
+SIZE (pyteomics-4.5.3.tar.gz) = 202088