diff --git a/science/py-nibabel/Makefile b/science/py-nibabel/Makefile
index 4396ad1629ac..14e0858a154f 100644
--- a/science/py-nibabel/Makefile
+++ b/science/py-nibabel/Makefile
@@ -1,23 +1,29 @@
 PORTNAME=	nibabel
-DISTVERSION=	3.2.2
-PORTREVISION=	1
+DISTVERSION=	5.1.0
 CATEGORIES=	science python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Read/write some common neuroimaging file formats
 WWW=		https://nipy.org/nibabel/
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/COPYING
 
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}hatch-vcs>0:devel/py-hatch-vcs@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}hatchling>0:devel/py-hatchling@${PY_FLAVOR}
 RUN_DEPENDS=	${PYNUMPY} \
-		${PYTHON_PKGNAMEPREFIX}packaging>0:devel/py-packaging@${PY_FLAVOR}
+		${PYTHON_PKGNAMEPREFIX}packaging>=17:devel/py-packaging@${PY_FLAVOR}
 
-USES=		python:3.6+
-USE_PYTHON=	distutils concurrent autoplist
+USES=		python:3.9+
+USE_PYTHON=	pep517 concurrent autoplist pytest
 
 NO_ARCH=	yes
 
+post-install:
+	@${REINPLACE_CMD} -i '' -e 's|#!python|#!${PYTHON_CMD}|' \
+		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/nibabel/cmdline/diff.py  \
+		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/nibabel/cmdline/ls.py 
+
 .include <bsd.port.mk>
diff --git a/science/py-nibabel/distinfo b/science/py-nibabel/distinfo
index c44c5d494b42..ff31754abb6c 100644
--- a/science/py-nibabel/distinfo
+++ b/science/py-nibabel/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1650778012
-SHA256 (nibabel-3.2.2.tar.gz) = b0dcc174b30405ce9e8fec1eab3cbbb20f5c5e4920976c08b22e050b7c124f94
-SIZE (nibabel-3.2.2.tar.gz) = 4738019
+TIMESTAMP = 1687839690
+SHA256 (nibabel-5.1.0.tar.gz) = ce73ca5e957209e7219a223cb71f77235c9df2acf4d3f27f861ba38e9481ac53
+SIZE (nibabel-5.1.0.tar.gz) = 4498348