diff --git a/science/py-OpenFermion/Makefile b/science/py-OpenFermion/Makefile
index caadb69162c4..c5898f3e1833 100644
--- a/science/py-OpenFermion/Makefile
+++ b/science/py-OpenFermion/Makefile
@@ -1,38 +1,50 @@
 PORTNAME=	OpenFermion
 DISTVERSIONPREFIX=	v
-DISTVERSION=	1.8.0
+DISTVERSION=	1.8.1
 CATEGORIES=	science python # quantum-computing
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Electronic structure package for quantum computers
 WWW=		https://github.com/quantumlib/OpenFermion
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cirq-core>=1.6.0:science/py-cirq-core@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}cirq-google>=0.15.0:science/py-cirq-google@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}deprecation>0:devel/py-deprecation@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}h5py>0:science/py-h5py@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}networkx>0:math/py-networkx@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}numpy>0:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}PubChemPy>0:science/py-PubChemPy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>0:www/py-requests@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>0:science/py-scipy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}sympy>0:math/py-sympy@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}nbformat>0:devel/py-nbformat@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	distutils autoplist pytest # 1 tests fails, see https://github.com/quantumlib/OpenFermion/issues/879
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	quantumlib
 
 NO_ARCH=	yes
 
 BINARY_ALIAS=	python3=${PYTHON_CMD} # only for tests
 
-# tests as of 1.7.1: 2 failed, 2157 passed, 60 skipped, 218 warnings in 3296.13s (0:54:56)
+# tests hang wihout these ignores/deselects:
+TEST_ARGS=	--ignore=src/openfermion/testing/performance_benchmarks_test.py \
+		--ignore=src/openfermion/testing/lih_integration_test.py \
+		--ignore=src/openfermion/linalg/davidson_test.py \
+		--ignore=src/openfermion/linalg/linear_qubit_operator_test.py \
+		--ignore=src/openfermion/hamiltonians/jellium_test.py \
+		--ignore=src/openfermion/hamiltonians/plane_wave_hamiltonian_test.py \
+		--ignore=src/openfermion/chem/pubchem_test.py \
+		--deselect=src/openfermion/ops/representations/doci_hamiltonian_test.py::IntegralTransformsTest::test_fermionic_hamiltonian_from_integrals \
+		--deselect=src/openfermion/transforms/opconversions/remove_symmetry_qubits_test.py::ReduceSymmetryQubitsTest::test_energy_reduce_symmetry_qubits \
+		--deselect=src/openfermion/transforms/opconversions/verstraete_cirac_test.py::VerstraeteCirac2dSquareGroundStateTest::test_ground_energy
+
+# tests as of 1.8.1: 2112 passed, 60 skipped, 3 deselected, 17 warnings in 1499.31s (0:24:59)
 
 .include <bsd.port.mk>
diff --git a/science/py-OpenFermion/distinfo b/science/py-OpenFermion/distinfo
index 3f607337eaac..07724404c86e 100644
--- a/science/py-OpenFermion/distinfo
+++ b/science/py-OpenFermion/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1784098492
-SHA256 (quantumlib-OpenFermion-v1.8.0_GH0.tar.gz) = bdc49e2f37a4580d2af58bfecdf672e046b22c83f5c770d363b1cac4256dacd5
-SIZE (quantumlib-OpenFermion-v1.8.0_GH0.tar.gz) = 45505341
+TIMESTAMP = 1784748576
+SHA256 (quantumlib-OpenFermion-v1.8.1_GH0.tar.gz) = d03703c309df12046e9285bbd1f1d434e3774e56248a5b860a1779c9d3b291cb
+SIZE (quantumlib-OpenFermion-v1.8.1_GH0.tar.gz) = 45506202
diff --git a/science/py-OpenFermion/files/patch-conftest.py b/science/py-OpenFermion/files/patch-conftest.py
new file mode 100644
index 000000000000..04936589bbf4
--- /dev/null
+++ b/science/py-OpenFermion/files/patch-conftest.py
@@ -0,0 +1,17 @@
+--- conftest.py.orig	2026-07-22 21:48:17 UTC
++++ conftest.py
+@@ -14,6 +14,14 @@ import sys
+ import os
+ import sys
+ 
++# The deprecated pynvml package installs a meta path finder whose
++# find_spec() signature is incompatible with Python 3.12 and breaks
++# cirq import when pynvml happens to be present in the test environment.
++for _finder in sys.meta_path[:]:
++    if type(_finder).__name__ == "PynvmlFinder":
++        sys.meta_path.remove(_finder)
++del _finder
++
+ # Ensure src/ is in sys.path so that the OpenFermion utils module can be
+ # imported at Pytest startup time.
+ sys.path.insert(0, os.path.abspath(os.path.join(os.path.dirname(__file__), "src")))