diff --git a/science/mmdb2/Makefile b/science/mmdb2/Makefile
index c2847e3edfed..dbfa00cfb69c 100644
--- a/science/mmdb2/Makefile
+++ b/science/mmdb2/Makefile
@@ -1,19 +1,22 @@
 PORTNAME=	mmdb2
-DISTVERSION=	2.0.20
+DISTVERSION=	2.0.22
 CATEGORIES=	science
 MASTER_SITES=	https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/dependencies/
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	C++ toolkit for working with macromolecular coordinate files
 
 LICENSE=	GPLv3 LGPL3
 LICENSE_COMB=	dual
 LICENSE_FILE_GPLv3=	${WRKSRC}/COPYING
 LICENSE_FILE_LGPL3=	${WRKSRC}/COPYING.LESSER
 
 USES=		gmake libtool
+USE_LDCONFIG=	yes
+
 GNU_CONFIGURE=	yes
 CONFIGURE_ARGS=	--enable-shared --disable-static
-USE_LDCONFIG=	yes
+
+INSTALL_TARGET=	install-strip
 
 .include <bsd.port.mk>
diff --git a/science/mmdb2/distinfo b/science/mmdb2/distinfo
index 0fd3af9f72dd..373030dc8dab 100644
--- a/science/mmdb2/distinfo
+++ b/science/mmdb2/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1578886191
-SHA256 (mmdb2-2.0.20.tar.gz) = 75f3ea5f3715f7fe36f43ca9e4de30d1d9ed33b759bbb311575ed875bf5c045f
-SIZE (mmdb2-2.0.20.tar.gz) = 725868
+TIMESTAMP = 1651333778
+SHA256 (mmdb2-2.0.22.tar.gz) = a9646933ce9f34633e1ae4901f2383af0e5318d6490851328f5b6aa06195ab51
+SIZE (mmdb2-2.0.22.tar.gz) = 737837