diff --git a/databases/py-tiledb/Makefile b/databases/py-tiledb/Makefile
index 86b9043e59e0..d8331f9ffcb5 100644
--- a/databases/py-tiledb/Makefile
+++ b/databases/py-tiledb/Makefile
@@ -1,33 +1,33 @@
 PORTNAME=	tiledb
-PORTVERSION=	0.16.3
+PORTVERSION=	0.16.4
 CATEGORIES=	databases python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python interface to the TileDB array storage manager
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 NOT_FOR_ARCHS=	i386
 NOT_FOR_ARCHS_REASON=	is currently 64-bit only
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython>=0.27:lang/cython@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}numpy>=1.19.2,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pybind11>=2.6.2:devel/py-pybind11@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools_scm>=1.5.4:devel/py-setuptools_scm@${PY_FLAVOR} \
-		tiledb>=2.10.2:databases/tiledb
+		tiledb>=2.10.3:databases/tiledb
 LIB_DEPENDS=	libtiledb.so:databases/tiledb
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=1.19.2,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}packaging>=0:devel/py-packaging@${PY_FLAVOR}
 
 USES=		compiler:c++14-lang localbase python:3.7+
 USE_PYTHON=	autoplist concurrent cython distutils
 
 MAKE_ENV=	TILEDB_PATH=${LOCALBASE}
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/databases/py-tiledb/distinfo b/databases/py-tiledb/distinfo
index d12eec2ef30b..111cc6e643f5 100644
--- a/databases/py-tiledb/distinfo
+++ b/databases/py-tiledb/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1657719090
-SHA256 (tiledb-0.16.3.tar.gz) = 55217d73327377a8defc48c140e0005e1102c0d9c1e02a3d5cb3ee594d5e65cf
-SIZE (tiledb-0.16.3.tar.gz) = 291877
+TIMESTAMP = 1660576742
+SHA256 (tiledb-0.16.4.tar.gz) = f49ad4b0ad5b1767702fad912fac1f15d6f81698fc9ec7d2edd10bd8077887ce
+SIZE (tiledb-0.16.4.tar.gz) = 292764
diff --git a/databases/py-tiledb/files/patch-requirements_dev.txt b/databases/py-tiledb/files/patch-requirements_dev.txt
index 00537805a629..abefeb16c499 100644
--- a/databases/py-tiledb/files/patch-requirements_dev.txt
+++ b/databases/py-tiledb/files/patch-requirements_dev.txt
@@ -1,18 +1,17 @@
---- requirements_dev.txt.orig	2022-06-24 21:27:10 UTC
+--- requirements_dev.txt.orig	2022-08-03 17:50:09 UTC
 +++ requirements_dev.txt
-@@ -1,14 +1,8 @@
+@@ -1,13 +1,8 @@
  numpy >= 1.16.5
  
 -# ------------------------------------------------
 -# ** MUST sync with misc/requirements_wheel.txt **
 -# ------------------------------------------------
--# Note 11/23/2021: the current version of the AWS sdk does not work with cmake 3.22
--cmake >= 3.21, < 3.22
+-cmake >= 3.23
  cython >= 0.27
  pybind11 >= 2.6.2
 -setuptools >= 18.0, <= 59.5.0
 +setuptools >= 18.0
  setuptools_scm >= 1.5.4
 -wheel >= 0.30
  contextvars ;python_version<"3.7"
  dataclasses ;python_version<"3.7"