diff --git a/biology/py-PySCeS/Makefile b/biology/py-PySCeS/Makefile
index d50bb3ccd733..5d0d40274f5a 100644
--- a/biology/py-PySCeS/Makefile
+++ b/biology/py-PySCeS/Makefile
@@ -1,40 +1,40 @@
 PORTNAME=	pysces
-DISTVERSION=	1.2.1
+DISTVERSION=	1.2.2
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	${PORTNAME:tl}-${DISTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python Simulator for Cellular Systems
 WWW=		https://pysces.github.io/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}meson-python>0:devel/meson-python@${PY_FLAVOR} \
 		${PYNUMPY}
 PY_EXTRA=	${PYTHON_PKGNAMEPREFIX}python-libsbml>0:biology/py-python-libsbml@${PY_FLAVOR}
 RUN_DEPENDS=	${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}matplotlib>0:math/py-matplotlib@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>0:science/py-scipy@${PY_FLAVOR} \
 		${PY_EXTRA}
 
 USES=		fortran localbase:ldflags python
 USE_PYTHON=	pep517 autoplist pytest
 
 LDFLAGS+=	-lpython${PYTHON_VER}
 
 BINARY_ALIAS=	python3=${PYTHON_CMD}
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/pysces/pitcon/pitcon.cpython-${PYTHON_SUFFIX}.so \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/pysces/nleq2/nleq2.cpython-${PYTHON_SUFFIX}.so
 
 do-test: # from section 2.1 Loading PySCeS in http://pysces.sourceforge.net/pdf/userguide.pdf
 	@${SETENV} ${TEST_ENV} ${PYTHON_CMD} -c "import pysces; pysces.test();"
 
 .include <bsd.port.mk>
diff --git a/biology/py-PySCeS/distinfo b/biology/py-PySCeS/distinfo
index 2d91e6fed642..88232acfde21 100644
--- a/biology/py-PySCeS/distinfo
+++ b/biology/py-PySCeS/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1716746850
-SHA256 (pysces-1.2.1.tar.gz) = 5dbde64cf398c599f5303d9ce084a50e047080c0899951529774a822a549fc20
-SIZE (pysces-1.2.1.tar.gz) = 2753986
+TIMESTAMP = 1722664974
+SHA256 (pysces-1.2.2.tar.gz) = 8d71e330594d63281ed88de9925776497f57c0952092d2a87df0c031cb6c8101
+SIZE (pysces-1.2.2.tar.gz) = 2754765
diff --git a/biology/py-PySCeS/files/patch-pyproject.toml b/biology/py-PySCeS/files/patch-pyproject.toml
index 334fd0cf97b2..5416c3ea1171 100644
--- a/biology/py-PySCeS/files/patch-pyproject.toml
+++ b/biology/py-PySCeS/files/patch-pyproject.toml
@@ -1,12 +1,12 @@
---- pyproject.toml.orig	2024-04-05 22:51:04 UTC
+--- pyproject.toml.orig	2024-08-02 13:17:23 UTC
 +++ pyproject.toml
 @@ -3,8 +3,7 @@ requires = [
  requires = [
    'meson-python',
    'meson>=1.2.3',
 -	'ninja',
--	'numpy>=1.26.0,<1.27',
+-	'numpy>=2.0.0',
 +	'numpy',
  ]
  
  [tool.meson-python.args]