diff --git a/biology/py-resdk/Makefile b/biology/py-resdk/Makefile
index de263472e0e9..36816ccf9fb1 100644
--- a/biology/py-resdk/Makefile
+++ b/biology/py-resdk/Makefile
@@ -1,41 +1,43 @@
 PORTNAME=	resdk
-DISTVERSION=	21.2.1
+DISTVERSION=	22.0.0
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Resolwe SDK to interact with Resolwe server and Resolwe Bioinformatics
 WWW=		https://github.com/genialis/resolwe-bio-py
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PY_SETUPTOOLS} \
 		${PYTHON_PKGNAMEPREFIX}setuptools-scm>=6.4.0:devel/py-setuptools-scm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	\
 		${PYTHON_PKGNAMEPREFIX}aiohttp>=3.9.3:www/py-aiohttp@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}boto3>0:www/py-boto3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}botocore-stubs>0:www/py-botocore-stubs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}chardet<=5.2.0,1:textproc/py-chardet@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}openpyxl>0:textproc/py-openpyxl@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}packaging>0:devel/py-packaging@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pandas>0:math/py-pandas@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytz>0:devel/py-pytz@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>0:www/py-requests@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}slumber>=0.7.1:www/py-slumber@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tqdm>0:misc/py-tqdm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tzlocal>0:devel/py-tzlocal@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wrapt>0:devel/py-wrapt@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}xlrd>0:textproc/py-xlrd@${PY_FLAVOR}
 RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}mypy-boto3-s3>0:devel/py-mypy-boto3-s3@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	pep517 autoplist pytest
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 NO_ARCH=	yes
 
+# tests as of 22.0.0: 171 passed, 1 warning in 9.20s
+
 .include <bsd.port.mk>
diff --git a/biology/py-resdk/distinfo b/biology/py-resdk/distinfo
index 26e426f9c16b..7fd202fb4e22 100644
--- a/biology/py-resdk/distinfo
+++ b/biology/py-resdk/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1731244665
-SHA256 (resdk-21.2.1.tar.gz) = 5b231e655674f0362e72846bbf66e36afe82f595acbca32dbc77656517c21f2e
-SIZE (resdk-21.2.1.tar.gz) = 258693
+TIMESTAMP = 1743577078
+SHA256 (resdk-22.0.0.tar.gz) = 3fc0ea3f71c02621064b39bada380101f5810c0bf00e1d6df618ff1d8fab57e4
+SIZE (resdk-22.0.0.tar.gz) = 268555