diff --git a/biology/py-macs2/Makefile b/biology/py-macs2/Makefile
index 050437b65bbc..05e1ba41c4c7 100644
--- a/biology/py-macs2/Makefile
+++ b/biology/py-macs2/Makefile
@@ -1,30 +1,29 @@
 PORTNAME=		macs2
 DISTVERSIONPREFIX=	v
-DISTVERSION=		2.2.7.1
-PORTREVISION=	1
+DISTVERSION=		2.2.8
 CATEGORIES=		biology python
 PKGNAMEPREFIX=		${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Identify transcription factor binding sites
 WWW=		https://github.com/taoliu/MACS
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYNUMPY}
 RUN_DEPENDS=	${PYNUMPY}
 
 USES=		python:3.6+
 USE_PYTHON=	autoplist concurrent cython distutils
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	taoliu
 GH_PROJECT=	MACS
 
 post-stage:
 	${STRIP_CMD} \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/MACS2/*.so \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/MACS2/*/*.so
 
 .include <bsd.port.mk>
diff --git a/biology/py-macs2/distinfo b/biology/py-macs2/distinfo
index 296f6d147a29..1999b76a294d 100644
--- a/biology/py-macs2/distinfo
+++ b/biology/py-macs2/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1586702732
-SHA256 (taoliu-MACS-v2.2.7.1_GH0.tar.gz) = 8ba25c367b84e237487b01be947239bee80e3ba123afc5e6034c374413b32913
-SIZE (taoliu-MACS-v2.2.7.1_GH0.tar.gz) = 134872405
+TIMESTAMP = 1684361836
+SHA256 (taoliu-MACS-v2.2.8_GH0.tar.gz) = cab63d7e8b862dbd6bb8ed32325e4fee728d85306e47931167fef753ef0ee743
+SIZE (taoliu-MACS-v2.2.8_GH0.tar.gz) = 133108890