diff --git a/biology/vsearch/Makefile b/biology/vsearch/Makefile
index 9114059f7969..cc53c2da6511 100644
--- a/biology/vsearch/Makefile
+++ b/biology/vsearch/Makefile
@@ -1,29 +1,29 @@
 PORTNAME=		vsearch
 DISTVERSIONPREFIX=	v
-DISTVERSION=		2.29.2
+DISTVERSION=		2.29.4
 CATEGORIES=		biology
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Versatile open-source tool for metagenomics
 WWW=		https://github.com/torognes/vsearch
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 ONLY_FOR_ARCHS=		aarch64 amd64 powerpc64le
 ONLY_FOR_ARCHS_REASON=	Explicitly enumerated by upstream developers
 
 USES=		autoreconf ghostscript:build gmake localbase
 USE_GITHUB=	yes
 
 GH_ACCOUNT=	torognes
 GNU_CONFIGURE=	yes
 GNU_CONFIGURE_MANPREFIX=	${PREFIX}/share
 
 PLIST_FILES=	bin/vsearch share/man/man1/vsearch.1.gz
 PORTDOCS=	*
 
 OPTIONS_DEFINE=	DOCS
 OPTIONS_SUB=	yes
 
 .include <bsd.port.mk>
diff --git a/biology/vsearch/distinfo b/biology/vsearch/distinfo
index f28d72317e46..f1c1c4f6f3b3 100644
--- a/biology/vsearch/distinfo
+++ b/biology/vsearch/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1735504924
-SHA256 (torognes-vsearch-v2.29.2_GH0.tar.gz) = 7baf08c08f7c3e7488f3fe8d54909d5c1bf6ecbf590105323fb5444fe40ffeec
-SIZE (torognes-vsearch-v2.29.2_GH0.tar.gz) = 284526
+TIMESTAMP = 1739711942
+SHA256 (torognes-vsearch-v2.29.4_GH0.tar.gz) = ee55e764b01f538c4f3d3cf23b4550fe14d7a5922a8969ba14904dbb66064985
+SIZE (torognes-vsearch-v2.29.4_GH0.tar.gz) = 285118