diff --git a/biology/mothur/Makefile b/biology/mothur/Makefile
index 052c7316a429..9fc6c24779ba 100644
--- a/biology/mothur/Makefile
+++ b/biology/mothur/Makefile
@@ -1,29 +1,29 @@
 PORTNAME=	mothur
 DISTVERSIONPREFIX=	v
-DISTVERSION=	1.45.2
+DISTVERSION=	1.45.3
 CATEGORIES=	biology
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Software for bioinformatics of the microbial ecology community
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE.md
 
 BUILD_DEPENDS=	bash:shells/bash
 
 USES=		compiler:c++11-lang gmake localbase readline
 USE_GITHUB=	yes
 ALL_TARGET=	${PORTNAME}
 
 BINARY_ALIAS=	g++=${CXX}
 
 EXES=		${PORTNAME} uchime
 
 PLIST_FILES=	${EXES:S/^/bin\//}
 
 do-install: # https://github.com/mothur/mothur/issues/615
 .for e in ${EXES}
 	${INSTALL_PROGRAM} ${WRKSRC}/${e} ${STAGEDIR}${PREFIX}/bin
 .endfor
 
 .include <bsd.port.mk>
diff --git a/biology/mothur/distinfo b/biology/mothur/distinfo
index aa53703b0440..1843d68e9f3c 100644
--- a/biology/mothur/distinfo
+++ b/biology/mothur/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1618235513
-SHA256 (mothur-mothur-v1.45.2_GH0.tar.gz) = 73fddddfeea140537b8b037da971964091b2149177e376d98d19ba8a2183e471
-SIZE (mothur-mothur-v1.45.2_GH0.tar.gz) = 1614451
+TIMESTAMP = 1620575011
+SHA256 (mothur-mothur-v1.45.3_GH0.tar.gz) = 865317569260ab7fa8fde2cbe00bcc05e6402dcd97267615d863ede145f381e8
+SIZE (mothur-mothur-v1.45.3_GH0.tar.gz) = 1613336