diff --git a/devel/py-twisted/Makefile b/devel/py-twisted/Makefile
index 821c7f7b60ba..05c1ce6c941e 100644
--- a/devel/py-twisted/Makefile
+++ b/devel/py-twisted/Makefile
@@ -1,60 +1,60 @@
 # Created by: Johann Visagie <wjv@FreeBSD.org>
 
 PORTNAME=	twisted
-PORTVERSION=	21.7.0
+PORTVERSION=	22.1.0
 CATEGORIES=	devel net python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	Twisted-${PORTVERSION}
 
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	Asynchronous networking framework written in Python
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}incremental>=21.3.0:devel/py-incremental@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}attrs>=19.2.0:devel/py-attrs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}Automat>=0.8.0:devel/py-Automat@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}constantly>=15.1:devel/py-constantly@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}hyperlink>=17.1.1:www/py-hyperlink@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}incremental>=21.3.0:devel/py-incremental@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}PyHamcrest>=1.9.0:textproc/py-pyhamcrest@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}zope.interface>=4.4.2:devel/py-zope.interface@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}typing-extensions>=3.6.5:devel/py-typing-extensions@${PY_FLAVOR}
-TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}service_identity>0:security/py-service_identity@${PY_FLAVOR}
+TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}service_identity>0:security/py-service_identity@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}PyHamcrest>=1.9.0:textproc/py-pyhamcrest@${PY_FLAVOR}
 
-USES=		cpe python:3.7+
+USES=		cpe python:3.7-3.10
 USE_PYTHON=	autoplist concurrent distutils
 
 CPE_VENDOR=	twistedmatrix
 
 NO_ARCH=	yes
 
 OPTIONS_DEFINE=	CONCH HTTP2 SERIAL TLS
 OPTIONS_DEFAULT=CONCH HTTP2 SERIAL TLS
 CONCH_DESC=	Conch secure shell SSH
 SERIAL_DESC=	Serial port extension
 
 CONCH_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}appdirs>=1.4.0:devel/py-appdirs@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}bcrypt>=3.0.0:security/py-bcrypt@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}cryptography>=2.6:security/py-cryptography@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}pyasn1>=0:devel/py-pyasn1@${PY_FLAVOR}
 HTTP2_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}h2>=3.0<4.1:www/py-h2@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}priority1>=1.1.0<2.0:www/py-priority1@${PY_FLAVOR}
 SERIAL_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pyserial>=3.0:comms/py-pyserial@${PY_FLAVOR}
 TLS_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}idna>=2.4:dns/py-idna@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}openssl>=16.0.0:security/py-openssl@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}service_identity>=18.1.0:security/py-service_identity@${PY_FLAVOR}
 
 # We need twisted.trial in PYTHONPATH
 # twisted.conch tests depend on finding certain scripts in PATH
 TEST_ENV=	PYTHONPATH=${WRKSRC}/src PATH=${STAGEDIR}/${PREFIX}/bin:$$PATH
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR}/ -name '*.so' -exec ${STRIP_CMD} {} +
 
 do-test:
 	@cd ${WRKSRC} && ${SETENV} ${TEST_ENV} ${PYTHON_CMD} -m twisted.trial -e twisted
 
 .include <bsd.port.mk>
diff --git a/devel/py-twisted/distinfo b/devel/py-twisted/distinfo
index d12dda670c09..e0600d6a63d6 100644
--- a/devel/py-twisted/distinfo
+++ b/devel/py-twisted/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1627812458
-SHA256 (Twisted-21.7.0.tar.gz) = 2cd652542463277378b0d349f47c62f20d9306e57d1247baabd6d1d38a109006
-SIZE (Twisted-21.7.0.tar.gz) = 3739740
+TIMESTAMP = 1644250883
+SHA256 (Twisted-22.1.0.tar.gz) = b7971ec9805b0f80e1dcb1a3721d7bfad636d5f909de687430ce373979d67b61
+SIZE (Twisted-22.1.0.tar.gz) = 3729983