diff --git a/science/py-pydicom/Makefile b/science/py-pydicom/Makefile
index ebc64e4c6451..dc4e9f4c05fc 100644
--- a/science/py-pydicom/Makefile
+++ b/science/py-pydicom/Makefile
@@ -1,18 +1,20 @@
 PORTNAME=	pydicom
-PORTVERSION=	2.4.4
+PORTVERSION=	3.0.1
 DISTVERSIONPREFIX=v
 CATEGORIES=	science python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	wen@FreeBSD.org
 COMMENT=	Read, modify, and write DICOM files with Python code
 WWW=		https://github.com/pydicom/pydicom
 
 LICENSE=	MIT
 
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}flit-core>=3.2<4:devel/py-flit-core@${PY_FLAVOR}
+
 USES=		python shebangfix
 USE_GITHUB=	yes
-USE_PYTHON=	distutils autoplist
+USE_PYTHON=	autoplist pep517
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/science/py-pydicom/distinfo b/science/py-pydicom/distinfo
index c608554f51b0..ea5bfac20a89 100644
--- a/science/py-pydicom/distinfo
+++ b/science/py-pydicom/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1703765542
-SHA256 (pydicom-pydicom-v2.4.4_GH0.tar.gz) = 42c06ed74331174111dd42c89db774a13fc472abe18015f22c5aba80cddb7843
-SIZE (pydicom-pydicom-v2.4.4_GH0.tar.gz) = 2203904
+TIMESTAMP = 1728875678
+SHA256 (pydicom-pydicom-v3.0.1_GH0.tar.gz) = 848ae8e36f34750cf837e48ca5cdf6f7a472145724946d5f28f529279fe11f4e
+SIZE (pydicom-pydicom-v3.0.1_GH0.tar.gz) = 2899710