diff --git a/misc/snakemake/Makefile b/misc/snakemake/Makefile
index aea1ee03db7b..d8c8edf6532e 100644
--- a/misc/snakemake/Makefile
+++ b/misc/snakemake/Makefile
@@ -1,60 +1,65 @@
 PORTNAME=	snakemake
-DISTVERSION=	9.20.0
+DISTVERSION=	9.27.0
 CATEGORIES=	misc python
 MASTER_SITES=	PYPI
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Workflow management system
 WWW=		https://github.com/snakemake/snakemake
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.md
 
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>0:devel/py-setuptools@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}setuptools-scm>=8:devel/py-setuptools-scm@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}conda-inject>=1.3.1:devel/py-conda-inject@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}configargparse>0:devel/py-configargparse@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}connection_pool>=0.0.3:devel/py-connection_pool@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}docutils>0:textproc/py-docutils@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}docutils>=0.20:textproc/py-docutils@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}dpath>=2.1.6:devel/py-dpath@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}gitpython>0:devel/py-gitpython@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}humanfriendly>0:textproc/py-humanfriendly@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}immutables>0:devel/py-immutables@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}Jinja2>=3.0:devel/py-Jinja2@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}jsonschema>0:devel/py-jsonschema@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}nbformat>0:devel/py-nbformat@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}packaging>=24.0:devel/py-packaging@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}platformdirs>0:devel/py-platformdirs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}psutil>0:sysutils/py-psutil@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}PuLP>=2.3.1:math/py-PuLP@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pyyaml>0:devel/py-pyyaml@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}referencing>0:devel/py-referencing@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>=2.8.1:www/py-requests@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}smart-open>=4.0:net/py-smart-open@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}snakemake-interface-common>=1.20.1:misc/py-snakemake-interface-common@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}snakemake-interface-executor-plugins>=9.3.2:misc/py-snakemake-interface-executor-plugins@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}snakemake-interface-logger-plugins>=1.1.0:misc/py-snakemake-interface-logger-plugins@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}snakemake-interface-report-plugins>=1.2.0:misc/py-snakemake-interface-report-plugins@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}snakemake-interface-scheduler-plugins>=2.0.0:misc/py-snakemake-interface-scheduler-plugins@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}snakemake-interface-storage-plugins>=4.4.1:misc/py-snakemake-interface-storage-plugins@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}sqlmodel>=0.0.37:databases/py-sqlmodel@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tabulate>0:devel/py-tabulate@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tenacity>=9.1.4:devel/py-tenacity@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}throttler>0:devel/py-throttler@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wrapt>0:devel/py-wrapt@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}yte>=1.5.5:textproc/py-yte@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest>0:devel/py-pytest@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	distutils noflavors autoplist
+USE_PYTHON=	autoplist noflavors pep517
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
+TEST_ARGS=	--disable-plugin-autoload
 TEST_WRKSRC=	${WRKSRC}/tests
 
 do-test:
-	@cd ${WRKSRC} && ${SETENV} ${TEST_ENV} ${PYTHON_CMD} -m pytest \
+	@cd ${WRKSRC} && ${SETENV} ${TEST_ENV} ${PYTHON_CMD} -m pytest ${TEST_ARGS} \
 		tests/test_args.py tests/test_internals.py tests/test_io.py \
 		tests/test_prefix_lookup.py -v
 
 NO_ARCH=	yes
 
-# tests as of 9.20.0: 20 passed in 2.94s
+# tests as of 9.27.0: 30 passed in 1.54s
 
 .include <bsd.port.mk>
diff --git a/misc/snakemake/distinfo b/misc/snakemake/distinfo
index 4cdbfb11f626..a21013def3b1 100644
--- a/misc/snakemake/distinfo
+++ b/misc/snakemake/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1777842670
-SHA256 (snakemake-9.20.0.tar.gz) = 66ff407f4d0a471588bc35778ae1b0d3bd91ec94024f4317bdc3a0af68b9407c
-SIZE (snakemake-9.20.0.tar.gz) = 6785429
+TIMESTAMP = 1789544847
+SHA256 (snakemake-9.27.0.tar.gz) = cd80a66dda92d274af02244a0c861d7de8851402b23caadbcbcc101f4c04a0d6
+SIZE (snakemake-9.27.0.tar.gz) = 6818358
diff --git a/misc/snakemake/files/patch-pyproject.toml b/misc/snakemake/files/patch-pyproject.toml
index 06bcc1420cac..0ee44d216109 100644
--- a/misc/snakemake/files/patch-pyproject.toml
+++ b/misc/snakemake/files/patch-pyproject.toml
@@ -1,28 +1,35 @@
---- pyproject.toml.orig	2026-04-19 17:03:43 UTC
+--- pyproject.toml.orig	2026-09-11 13:45:17 UTC
 +++ pyproject.toml
+@@ -1,5 +1,5 @@
+ [build-system]
+-requires = ["setuptools>=64", "setuptools-scm>=8"]
++requires = ["setuptools", "setuptools-scm>=8"]
+ build-backend = "setuptools.build_meta"
+ 
+ [project]
 @@ -15,7 +15,6 @@ requires-python = ">= 3.11"
    how to create output files from input files.
  """ }
  requires-python = ">= 3.11"
 -license = "MIT"
  authors = [{ name = "Johannes Köster", email = "johannes.koester@uni-due.de" }]
  classifiers = [
    "Development Status :: 5 - Production/Stable",
-@@ -40,7 +39,7 @@ dependencies = [
+@@ -41,7 +40,7 @@ dependencies = [
    "jinja2>=3.0,<4.0",
    "jsonschema",
    "nbformat",
 -  "packaging >=24.0,<26",
 +  "packaging>=24.0",
    "psutil",
    "pulp>=2.3.1,<3.4",
    "pyyaml",
-@@ -60,7 +59,7 @@ dependencies = [
+@@ -61,7 +60,7 @@ dependencies = [
    "yte>=1.5.5,<2.0",
    "dpath>=2.1.6,<3.0.0",
    "conda-inject>=1.3.1,<2.0",
 -  "sqlmodel>=0.0.37,<0.0.38",
 +  "sqlmodel>=0.0.37",
  ]
  
  [project.urls]