diff --git a/devel/py-anndata/Makefile b/devel/py-anndata/Makefile
index 302af2ca2ff2..f171f9d35fe4 100644
--- a/devel/py-anndata/Makefile
+++ b/devel/py-anndata/Makefile
@@ -1,34 +1,34 @@
 PORTNAME=	anndata
-PORTVERSION=	0.12.14
+PORTVERSION=	0.12.16
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Annotated data
 WWW=		https://anndata.readthedocs.io/en/stable/ \
 		https://github.com/scverse/anndata
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}hatch-vcs>=0:devel/py-hatch-vcs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}hatchling>=0:devel/py-hatchling@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}array-api-compat>=1.7.1:devel/py-array-api-compat@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}h5py>=3.8:science/py-h5py@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}legacy-api-wrap>=0:devel/py-legacy-api-wrap@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}natsort>=0:devel/py-natsort@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}numpy>=1.26,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}packaging>=24.2:devel/py-packaging@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pandas>=2.1.0,1<3,1:math/py-pandas@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pooch>=0:devel/py-pooch@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=1.12:science/py-scipy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scverse-misc>=0.0.3:devel/py-scverse-misc@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}zarr>=2.18.4:devel/py-zarr@${PY_FLAVOR}
 
 USES=		python:3.11+
 USE_PYTHON=	autoplist concurrent pep517
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/devel/py-anndata/distinfo b/devel/py-anndata/distinfo
index 22ed21002a5a..2423e078389e 100644
--- a/devel/py-anndata/distinfo
+++ b/devel/py-anndata/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1778677908
-SHA256 (anndata-0.12.14.tar.gz) = 52c852246eae20b469753f51f1481e034fb15f5218878f8695fd0e111c4c6da1
-SIZE (anndata-0.12.14.tar.gz) = 2255427
+TIMESTAMP = 1779222930
+SHA256 (anndata-0.12.16.tar.gz) = 26d557fd147728993aac99c2eef676e1e316a84bbeee3c176ca6c5d66e5fc443
+SIZE (anndata-0.12.16.tar.gz) = 2255740