diff --git a/biology/hyphy/Makefile b/biology/hyphy/Makefile
index 2ac2c78ea0c5..d9918b6e01b3 100644
--- a/biology/hyphy/Makefile
+++ b/biology/hyphy/Makefile
@@ -1,27 +1,27 @@
 PORTNAME=	hyphy
-DISTVERSION=	2.5.52
+DISTVERSION=	2.5.53
 CATEGORIES=	biology
 
 MAINTAINER=	jrm@FreeBSD.org
 COMMENT=	Hypothesis testing using Phylogenies
 WWW=		https://www.hyphy.org/
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 ONLY_FOR_ARCHS=	aarch64 amd64 i386 powerpc powerpc64 powerpc64le
 
 LIB_DEPENDS=	libcurl.so:ftp/curl
 TEST_DEPENDS=	bash:shells/bash
 
 USES=		cmake:insource,testing localbase:ldflags # tests fail in outsource build, see https://github.com/veg/hyphy/issues/1528
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	veg
 
 OPTIONS_DEFINE=	AVX
 AVX_DESC=	Advanced vector extensions support
 
 AVX_CMAKE_OFF=	-DNOAVX:BOOL=ON
 
 .include <bsd.port.mk>
diff --git a/biology/hyphy/distinfo b/biology/hyphy/distinfo
index d0aac6efd8a0..ff8fda595390 100644
--- a/biology/hyphy/distinfo
+++ b/biology/hyphy/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1691588992
-SHA256 (veg-hyphy-2.5.52_GH0.tar.gz) = 9e57d7af4a2bb765c48e4eccd025f22a64b692e8951f258e7b9134f7bd8bffed
-SIZE (veg-hyphy-2.5.52_GH0.tar.gz) = 5633837
+TIMESTAMP = 1693924059
+SHA256 (veg-hyphy-2.5.53_GH0.tar.gz) = a8140eaa3c10b2a9ded9d15fab50804fa69f9d21c773a54f8ec0eb7b90bae135
+SIZE (veg-hyphy-2.5.53_GH0.tar.gz) = 5633739