diff --git a/math/py-ml-dtypes/Makefile b/math/py-ml-dtypes/Makefile
index 63b27391cb34..8bb36e2d588a 100644
--- a/math/py-ml-dtypes/Makefile
+++ b/math/py-ml-dtypes/Makefile
@@ -1,27 +1,25 @@
 PORTNAME=	ml-dtypes
-PORTVERSION=	0.5.1
-PORTREVISION=	2
+PORTVERSION=	0.6.0
 CATEGORIES=	math python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	ml_dtypes-${PORTVERSION}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Stand-alone implementation of several NumPy dtype extensions
 WWW=		https://github.com/jax-ml/ml_dtypes
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=2.0,1<3,1:math/py-numpy@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=2.1.0,1:math/py-numpy@${PY_FLAVOR}
+		${PYTHON_PKGNAMEPREFIX}scikit-build-core>=0:devel/py-scikit-build-core@${PY_FLAVOR}
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=2.3.0,1:math/py-numpy@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	autoplist concurrent pep517
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/math/py-ml-dtypes/distinfo b/math/py-ml-dtypes/distinfo
index fc3946fc55a5..aa452032cce3 100644
--- a/math/py-ml-dtypes/distinfo
+++ b/math/py-ml-dtypes/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1738089116
-SHA256 (ml_dtypes-0.5.1.tar.gz) = ac5b58559bb84a95848ed6984eb8013249f90b6bab62aa5acbad876e256002c9
-SIZE (ml_dtypes-0.5.1.tar.gz) = 698772
+TIMESTAMP = 1788500256
+SHA256 (ml_dtypes-0.6.0.tar.gz) = 5e60251d32ced5598972e4d5e06a2f044341f9291402551a3f6f0ec44f9299b0
+SIZE (ml_dtypes-0.6.0.tar.gz) = 3032327
diff --git a/math/py-ml-dtypes/files/patch-pyproject.toml b/math/py-ml-dtypes/files/patch-pyproject.toml
index 23cd5429a7c2..734d7fd99d9d 100644
--- a/math/py-ml-dtypes/files/patch-pyproject.toml
+++ b/math/py-ml-dtypes/files/patch-pyproject.toml
@@ -1,11 +1,12 @@
---- pyproject.toml.orig	2025-01-07 02:25:37 UTC
+--- pyproject.toml.orig	2022-11-09 12:37:21 UTC
 +++ pyproject.toml
-@@ -52,7 +52,7 @@ requires = [
-     # We build against the most recent supported NumPy 2.0 release;
-     # see https://github.com/numpy/numpy/issues/27265
-     "numpy~=2.0",
--    "setuptools~=75.7.0",
-+    "setuptools",
- ]
- build-backend = "setuptools.build_meta"
- 
+@@ -4,8 +4,7 @@ requires-python = ">=3.10"
+ description = "ml_dtypes is a stand-alone implementation of several NumPy dtype extensions used in machine learning."
+ readme = "README.md"
+ requires-python = ">=3.10"
+-license = "Apache-2.0"
+-license-files = ["LICENSE", "LICENSE.eigen"]
++license = {file = "LICENSE"}
+ authors = [{name = "ml_dtypes authors", email="ml_dtypes@google.com"}]
+ classifiers = [
+     "Programming Language :: Python :: 3",