diff --git a/devel/py-pyquil/Makefile b/devel/py-pyquil/Makefile
index 4d808d85a745..ca5f1ab7ce13 100644
--- a/devel/py-pyquil/Makefile
+++ b/devel/py-pyquil/Makefile
@@ -1,32 +1,34 @@
 PORTNAME=	pyquil
-DISTVERSION=	3.5.0
+DISTVERSION=	4.5.0
 CATEGORIES=	devel python # quantum-computing
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	PyQuil: Quantum programming in Python
 WWW=		https://github.com/rigetti/pyquil
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}poetry-core>=1.0.0:devel/py-poetry-core@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}lark>=0.11.1:devel/py-lark@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}networkx>=2.5:math/py-networkx@${PY_FLAVOR} \
 		${PYNUMPY} \
-		${PYTHON_PKGNAMEPREFIX}qcs-api-client>=0.21.0:devel/py-qcs-api-client@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}packaging>=23.1<24.0:devel/py-packaging@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}pydantic>=1.10.7:devel/py-pydantic@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}qcs-sdk-python>=0.16.3:devel/py-qcs-sdk-python@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}retry2>=0.9.2,<0.10.0:devel/py-retry2@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}rpcq>=3.10.0,<4.0.0:devel/py-rpcq@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}scipy>=1.6.1,<2.0.0:science/py-scipy@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}tenacity>=8.2.2:devel/py-tenacity@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}rpcq>=3.10.0<4.0.0:devel/py-rpcq@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}scipy>=1.7.3<2.0.0:science/py-scipy@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}tenacity>=8.2.2<9.0.0:devel/py-tenacity@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}types-python-dateutil>=2.8.19:devel/py-types-python-dateutil@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}types-retry>=0.9.9:devel/py-types-retry@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}types-retry>=0.9.9<1.0.0:devel/py-types-retry@${PY_FLAVOR} \
 		quilc:lang/quilc
 
 USES=		python
 USE_PYTHON=	pep517 autoplist
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/devel/py-pyquil/distinfo b/devel/py-pyquil/distinfo
index b79ddef7a4de..e954b46cc6bf 100644
--- a/devel/py-pyquil/distinfo
+++ b/devel/py-pyquil/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1706161849
-SHA256 (pyquil-3.5.0.tar.gz) = e11ce9f6d2c9f8f3f2d22c9f18c63c2b360ec2794b716910b18f7109d1cf5901
-SIZE (pyquil-3.5.0.tar.gz) = 181583
+TIMESTAMP = 1706300868
+SHA256 (pyquil-4.5.0.tar.gz) = b4e125d2712df70a3cd0d6af3b4ed043f026744ea5f2a46d460d35e2ca657ab0
+SIZE (pyquil-4.5.0.tar.gz) = 163317