diff --git a/textproc/py-pikepdf/Makefile b/textproc/py-pikepdf/Makefile
index 3d8664969c42..e0d753f3330e 100644
--- a/textproc/py-pikepdf/Makefile
+++ b/textproc/py-pikepdf/Makefile
@@ -1,50 +1,50 @@
 PORTNAME=	pikepdf
-DISTVERSION=	2.12.0
+DISTVERSION=	2.16.1
 CATEGORIES=	textproc python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	wen@FreeBSD.org
 COMMENT=	Read and write PDFs with Python, powered by qpdf
 
 LICENSE=	MPL20
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pybind11>=2.6.0<3:devel/py-pybind11@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools_scm>0:devel/py-setuptools_scm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools_scm_git_archive>0:devel/py-setuptools_scm_git_archive@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libqpdf.so:print/qpdf
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}lxml>=4.0:devel/py-lxml@${PY_FLAVOR} \
 		${PY_PILLOW}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}attrs>=20.2.0:devel/py-attrs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}dateutil>=2.8.0:devel/py-dateutil@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}hypothesis>=0:devel/py-hypothesis@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}psutil>=5<6:sysutils/py-psutil@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pybind11>=2.6.0:devel/py-pybind11@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest>=4.4.0<7.3.5:devel/py-pytest@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-helpers-namespace>=2019.1.8:devel/py-pytest-helpers-namespace@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-timeout>=1.3.3:devel/py-pytest-timeout@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-xdist>=1.28<3:devel/py-pytest-xdist@${PY_FLAVOR} \
 		${PY_PILLOW} \
 		${PYTHON_PKGNAMEPREFIX}python-xmp-toolkit>=2.0.1:textproc/py-python-xmp-toolkit@${PY_FLAVOR}
 
 USES=		compiler:c++14-lang python:3.6+
 USE_PYTHON=	distutils autoplist
 
 TEST_ENV=	LC_ALL=en_US.UTF-8
 
 OPTIONS_DEFINE=	JBIG2
 OPTIONS_DEFAULT=	JBIG2
 
 JBIG2_DESC=	Support for extracting JBIG2 images
 
 JBIG2_RUN_DEPENDS=	jbig2dec:graphics/jbig2dec
 
 post-install:
 	${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/pikepdf/_qpdf*.so
 
 do-test:
 	@cd ${WRKSRC} && ${SETENV} ${TEST_ENV} ${PYTHON_CMD} -m pytest -rs -v -o addopts=
 
 .include <bsd.port.mk>
diff --git a/textproc/py-pikepdf/distinfo b/textproc/py-pikepdf/distinfo
index d90ee6607870..4b41c016d063 100644
--- a/textproc/py-pikepdf/distinfo
+++ b/textproc/py-pikepdf/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1621217386
-SHA256 (pikepdf-2.12.0.tar.gz) = fcbb6e37426564ccaf6bb301616700277d426225895b00a64283a95ff648f3b9
-SIZE (pikepdf-2.12.0.tar.gz) = 2309822
+TIMESTAMP = 1627606299
+SHA256 (pikepdf-2.16.1.tar.gz) = e24dff6af31f1eb732fcb5db4678835d1f312643996fdcd9dbeb8aca52bc0dde
+SIZE (pikepdf-2.16.1.tar.gz) = 2322845
diff --git a/textproc/py-pikepdf/files/patch-setup.py b/textproc/py-pikepdf/files/patch-setup.py
deleted file mode 100644
index 7e388941d8e8..000000000000
--- a/textproc/py-pikepdf/files/patch-setup.py
+++ /dev/null
@@ -1,16 +0,0 @@
-Relax build requirements as devel/py-setuptools in the Ports tree is still
-at release 44.0 due Python 2.7.
-
---- setup.py.orig	2021-01-27 00:16:08 UTC
-+++ setup.py
-@@ -88,8 +88,8 @@ if __name__ == '__main__':
-             'Pillow >= 6',  # only needed for manipulating images
-         ],
-         setup_requires=[
--            'setuptools >= 50',
--            'wheel >= 0.35',
-+            'setuptools',
-+            'wheel',
-             'setuptools_scm[toml] >= 4.1',
-             'setuptools_scm_git_archive',
-             'pybind11 >= 2.6.0, <3',