diff --git a/science/py-py3Dmol/Makefile b/science/py-py3Dmol/Makefile
index 981386629d0b..75b09e606771 100644
--- a/science/py-py3Dmol/Makefile
+++ b/science/py-py3Dmol/Makefile
@@ -1,18 +1,20 @@
 PORTNAME=	py3Dmol
-DISTVERSION=	1.8.0
+DISTVERSION=	1.8.1
 CATEGORIES=	science python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	IPython interface for embedding 3Dmol.js views
 
 LICENSE=	WTFPL
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}ipython>0:devel/ipython@${PY_FLAVOR}
+
 USES=		python
 USE_PYTHON=	distutils autoplist
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/science/py-py3Dmol/distinfo b/science/py-py3Dmol/distinfo
index 2bb18793ce4f..eebdc6c38f5e 100644
--- a/science/py-py3Dmol/distinfo
+++ b/science/py-py3Dmol/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1655324790
-SHA256 (py3Dmol-1.8.0.tar.gz) = bc495e0f5204ea1e6fcb527a0332ee8765c3d4491e4ace9a9a72b790e89e9647
-SIZE (py3Dmol-1.8.0.tar.gz) = 6985
+TIMESTAMP = 1660247804
+SHA256 (py3Dmol-1.8.1.tar.gz) = 10bb3022c5db3e5e6d66f51d7d4118afaf939726d655f08761709ddf032cb31d
+SIZE (py3Dmol-1.8.1.tar.gz) = 7125