diff --git a/databases/py-gdbm/files/setup3.py b/databases/py-gdbm/files/setup3.py
index 0a947466d03e..26df5565cfd3 100644
--- a/databases/py-gdbm/files/setup3.py
+++ b/databases/py-gdbm/files/setup3.py
@@ -1,28 +1,30 @@
 #!/usr/bin/env python
 # To use:
 #       python setup.py install
 #
 
+import os
+import sys
+
 try:
-    import distutils
-    from distutils import sysconfig
-    from distutils.command.install import install
-    from distutils.core import setup, Extension
+    import setuptools
+    from setuptools.command.install import install
+    from setuptools import setup, Extension
 except:
     raise SystemExit("Distutils problem")
 
 install.sub_commands = [x for x in install.sub_commands if 'egg' not in x[0]]
 
-prefix = sysconfig.PREFIX
+prefix = os.path.normpath(sys.prefix)
 inc_dirs = [prefix + "/include"]
 lib_dirs = [prefix + "/lib"]
 libs = ["gdbm"]
 
 setup(name = "gdbm",
       description = "GDBM Extension to Python",
 
       ext_modules = [Extension('_gdbm', ['_gdbmmodule.c'],
                                include_dirs = inc_dirs,
                                libraries = libs,
                                library_dirs = lib_dirs)]
       )
diff --git a/databases/py-sqlite3/files/setup3.py b/databases/py-sqlite3/files/setup3.py
index 944c89920852..1a763dd8cb71 100644
--- a/databases/py-sqlite3/files/setup3.py
+++ b/databases/py-sqlite3/files/setup3.py
@@ -1,56 +1,57 @@
 #!/usr/bin/env python
 # To use:
 #       python setup.py install
 #
 
+import os
 import platform
+import sys
 
 try:
-    import distutils
-    from distutils import sysconfig
-    from distutils.command.install import install
-    from distutils.core import setup, Extension
+    import setuptools
+    from setuptools.command.install import install
+    from setuptools import setup, Extension
 except:
-    raise SystemExit("Distutils problem")
+    raise SystemExit("Setuptools problem")
 
 install.sub_commands = [x for x in install.sub_commands if 'egg' not in x[0]]
 
-prefix = sysconfig.PREFIX
+prefix = os.path.normpath(sys.prefix)
 inc_dirs = [prefix + "/include", "Modules/_sqlite"]
 lib_dirs = [prefix + "/lib"]
 libs = ["sqlite3"]
 macros = [('MODULE_NAME', '"sqlite3"')]
 sqlite_srcs = [
 '_sqlite/connection.c',
 '_sqlite/cursor.c',
 '_sqlite/microprotocols.c',
 '_sqlite/module.c',
 '_sqlite/prepare_protocol.c',
 '_sqlite/row.c',
 '_sqlite/statement.c',
 '_sqlite/util.c']
 
 major, minor = map(int, platform.python_version_tuple()[:2])
 
 if (major, minor) <= (3, 10):
     sqlite_srcs.append('_sqlite/cache.c',)
 
 if (major, minor) >= (3, 11):
     sqlite_srcs.append('_sqlite/blob.c',)
 
 try:
     import ctypes
     ctypes.CDLL('libsqlite3.so').sqlite3_load_extension
 except AttributeError:
     macros.append(('SQLITE_OMIT_LOAD_EXTENSION', '1'))
 
 setup(name = "sqlite3",
       description = "SQLite 3 extension to Python",
 
       ext_modules = [Extension('_sqlite3', sqlite_srcs,
                                include_dirs = inc_dirs,
                                libraries = libs,
                                library_dirs = lib_dirs,
                                runtime_library_dirs = lib_dirs,
                                define_macros = macros)]
       )
diff --git a/x11-toolkits/py-tkinter/files/setup3.py b/x11-toolkits/py-tkinter/files/setup3.py
index bcf53d093857..d0a7fc30c0bf 100644
--- a/x11-toolkits/py-tkinter/files/setup3.py
+++ b/x11-toolkits/py-tkinter/files/setup3.py
@@ -1,40 +1,40 @@
 #!/usr/bin/env python
 # To use:
 #       python setup.py install
 #
 
-import os, string
+import os
+import sys
 
 try:
-    import distutils
-    from distutils import sysconfig
-    from distutils.command.install import install
-    from distutils.core import setup, Extension
+    import setuptools
+    from setuptools.command.install import install
+    from setuptools import setup, Extension
 except:
     raise SystemExit("Distutils problem")
 
 install.sub_commands = [x for x in install.sub_commands if 'egg' not in x[0]]
 
 tkversion = "%%TK_VER%%"
-prefix = sysconfig.PREFIX
+prefix = os.path.normpath(sys.prefix)
 # Python 1.5 doesn't have os.getenv()?
 x11base = os.environ['LOCALBASE'] or '/usr/X11R6'
 inc_dirs = [prefix + "/include",
             prefix + "/include/tcl" + tkversion,
             prefix + "/include/tk" + tkversion,
             x11base + "/include"]
 lib_dirs = [prefix + "/lib", x11base + "/lib"]
 # use string.replace() for the benefit of Python 1.5 users
 libs = ["tcl" + tkversion.replace(".", ""),
         "tk" + tkversion.replace(".", ""),
         "X11"]
 
 setup(name = "Tkinter",
       description = "Tk Extension to Python",
 
       ext_modules = [Extension('_tkinter', ['_tkinter.c', 'tkappinit.c'],
                                define_macros=[('WITH_APPINIT', 1)],
                                include_dirs = inc_dirs,
                                libraries = libs,
                                library_dirs = lib_dirs)]
       )