diff --git a/devel/py-llvmlite/Makefile b/devel/py-llvmlite/Makefile
index 14bc4cf3525a..db49c24c611b 100644
--- a/devel/py-llvmlite/Makefile
+++ b/devel/py-llvmlite/Makefile
@@ -1,33 +1,35 @@
 PORTNAME=	llvmlite
 DISTVERSION=	0.46.0
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	makc@FreeBSD.org
 COMMENT=	Lightweight LLVM python binding for writing JIT compilers
 WWW=		https://github.com/numba/llvmlite
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	gmake:devel/gmake
+BUILD_DEPENDS=	gmake:devel/gmake \
+		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 
 # llvm compatibility table https://github.com/numba/llvmlite#compatibility
 USES=		cmake:indirect fortran llvm:20,lib python
-USE_PYTHON=	distutils autoplist pytest # many tests fail, see https://github.com/numba/llvmlite/issues/1015
+USE_PYTHON=	autoplist pep517 pytest # many tests fail, see https://github.com/numba/llvmlite/issues/1015
 
 MAKE_ENV=	LLVM_CONFIG=${LLVM_CONFIG} \
 		LLVMLITE_SHARED=ON \
 		CMAKE_ARGS=-DCMAKE_VERBOSE_MAKEFILE:BOOL=ON
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-patch:
 # Use required LLVM if multiple variants are present.
 	${REINPLACE_CMD} "s,%%LLVM_PREFIX%%,${LLVM_PREFIX}," ${WRKSRC}/ffi/CMakeLists.txt
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/llvmlite/binding/libllvmlite*.so
 
 .include <bsd.port.mk>
diff --git a/devel/py-llvmlite/files/patch-ffi_CMakeLists.txt b/devel/py-llvmlite/files/patch-ffi_CMakeLists.txt
index c3d7c41dc685..f3f27629d8bb 100644
--- a/devel/py-llvmlite/files/patch-ffi_CMakeLists.txt
+++ b/devel/py-llvmlite/files/patch-ffi_CMakeLists.txt
@@ -1,11 +1,11 @@
 --- ffi/CMakeLists.txt.orig	2025-12-08 17:44:54 UTC
 +++ ffi/CMakeLists.txt
 @@ -18,7 +18,7 @@ set(CMAKE_C_VISIBILITY_PRESET "hidden")
  set(CMAKE_CXX_VISIBILITY_PRESET "hidden")
  set(CMAKE_C_VISIBILITY_PRESET "hidden")
  
 -find_package(LLVM REQUIRED CONFIG)
-+find_package(LLVM REQUIRED CONFIG HINTS %%LLVM_PREFIX%%)
++find_package(LLVM REQUIRED CONFIG HINTS /usr/local/llvm20)
  
  message(STATUS "Found LLVM ${LLVM_PACKAGE_VERSION}")
  message(STATUS "Using LLVMConfig.cmake in: ${LLVM_DIR}")
diff --git a/devel/py-llvmlite/files/patch-setup.py b/devel/py-llvmlite/files/patch-setup.py
new file mode 100644
index 000000000000..bccf6e0a5989
--- /dev/null
+++ b/devel/py-llvmlite/files/patch-setup.py
@@ -0,0 +1,11 @@
+--- setup.py.orig	2026-03-13 12:44:44 UTC
++++ setup.py
+@@ -64,7 +64,7 @@ def build_library_files(dry_run):
+     plt = sys.platform
+     if 'linux' in plt or 'bsd' in plt or 'darwin' in plt or 'gnu' in plt:
+         os.environ['CXXFLAGS'] = os.environ.get('CXXFLAGS', '') + ' -fPIC'
+-    spawn(cmd, dry_run=dry_run)
++    spawn(cmd)
+ 
+ 
+ class LlvmliteBuild(build):