diff --git a/biology/hyphy/Makefile b/biology/hyphy/Makefile
index e9632df3e987..0e827bd9239e 100644
--- a/biology/hyphy/Makefile
+++ b/biology/hyphy/Makefile
@@ -1,28 +1,31 @@
 PORTNAME=	hyphy
 DISTVERSION=	2.5.77
+PORTREVISION=	1
 CATEGORIES=	biology
 
 MAINTAINER=	jrm@FreeBSD.org
 COMMENT=	Hypothesis testing using Phylogenies
 WWW=		https://www.hyphy.org/ \
 		https://github.com/veg/hyphy/
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 ONLY_FOR_ARCHS=	aarch64 amd64 i386 powerpc powerpc64 powerpc64le
 
 LIB_DEPENDS=	libcurl.so:ftp/curl
 TEST_DEPENDS=	bash:shells/bash
 
 USES=		cmake:insource,testing localbase:ldflags # tests fail in outsource build, see https://github.com/veg/hyphy/issues/1528
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	veg
 
-OPTIONS_DEFINE=	AVX
-AVX_DESC=	Advanced vector extensions support
+OPTIONS_DEFINE=		AVX TARGET_NATIVE
+AVX_DESC=		Advanced vector extensions support
+TARGET_NATIVE_DESC=	Enable CPU-specific instructions and tuning for build machine
 
-AVX_CMAKE_BOOL_OFF=	NOAVX
+AVX_CMAKE_BOOL_OFF=		NOAVX
+TARGET_NATIVE_CMAKE_BOOL=	TARGET_NATIVE
 
 .include <bsd.port.mk>