diff --git a/biology/diamond/Makefile b/biology/diamond/Makefile
index d36b66d5a9dd..690d48df2128 100644
--- a/biology/diamond/Makefile
+++ b/biology/diamond/Makefile
@@ -1,24 +1,24 @@
 PORTNAME=	diamond
 DISTVERSIONPREFIX=	v
-DISTVERSION=	2.2.0
+DISTVERSION=	2.2.1
 CATEGORIES=	biology
 
 MAINTAINER=	jrm@FreeBSD.org
 COMMENT=	BLAST-compatible local sequence aligner
 WWW=		http://ab.inf.uni-tuebingen.de/software/diamond/ \
 		https://github.com/bbuchfink/diamond
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 ONLY_FOR_ARCHS=	aarch64 amd64 powerpc64 powerpc64le
 
 USES=		cmake localbase sqlite
 USE_GITHUB=	yes
 GH_ACCOUNT=	bbuchfink
 
 TEST_TARGET=	test
 
 PLIST_FILES=	bin/diamond
 
 .include <bsd.port.mk>
diff --git a/biology/diamond/distinfo b/biology/diamond/distinfo
index e0f4cd34e16e..88f9ea0b2cfe 100644
--- a/biology/diamond/distinfo
+++ b/biology/diamond/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1778854250
-SHA256 (bbuchfink-diamond-v2.2.0_GH0.tar.gz) = d06d26cfa474e17132a9ea4c0a2a7ce4ec7e2ce937606173b401883d62eff730
-SIZE (bbuchfink-diamond-v2.2.0_GH0.tar.gz) = 1859725
+TIMESTAMP = 1782159924
+SHA256 (bbuchfink-diamond-v2.2.1_GH0.tar.gz) = 36a70540039c50e4afa1d36587eb80d1a85113288c2a49731cdaaf90e3de7d02
+SIZE (bbuchfink-diamond-v2.2.1_GH0.tar.gz) = 9358746