diff --git a/biology/bcf-score/Makefile b/biology/bcf-score/Makefile
index 0436c4b14f2d..bd2d2610e27e 100644
--- a/biology/bcf-score/Makefile
+++ b/biology/bcf-score/Makefile
@@ -1,60 +1,60 @@
 PORTNAME=	bcf-score
 DISTVERSION=	1.20
-PORTREVISION=	1
+PORTREVISION=	2
 CATEGORIES=	biology
 MASTER_SITES=	https://software.broadinstitute.org/software/score/
 # Get this right, or ports will download bcftools in it's place via tuple
 DISTFILES+=	score_${DISTVERSION}-20240505.tar.gz
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Bcftools plugins for GWAS-VCF summary statistics files
 WWW=		https://software.broadinstitute.org/software/score/
 
 LICENSE=	MIT
 
-BUILD_DEPENDS=	htslib>=1.21:biology/htslib
+BUILD_DEPENDS=	htslib>=1.22:biology/htslib
 LIB_DEPENDS=	libhts.so:biology/htslib libcholmod.so:math/suitesparse-cholmod
 TEST_DEPENDS=	bash:shells/bash
 RUN_DEPENDS=	bash:shells/bash bcftools>=${PORTVERSION}:biology/bcftools
 
 USES=		autoreconf gmake localbase perl5 python:env shebangfix
 USE_GITHUB=	yes
 USE_PERL5=	test
 
 GH_ACCOUNT=	samtools
 GH_PROJECT=	bcftools
-GH_TAGNAME=	1.21
+GH_TAGNAME=	1.22
 GNU_CONFIGURE=	yes
 SHEBANG_FILES=	misc/* test/test.pl
 
 # From pgs.mk
 CFLAGS+=	-isystem ${LOCALBASE}/include/suitesparse
 LDFLAGS+=	-lcholmod
 
 pre-configure:
 	@${REINPLACE_CMD} -e 's|@PORTVERSION@|${PORTVERSION}|g' \
 		${WRKSRC}/configure.ac
 
 post-extract:
 	@${CP} ${WRKDIR}/*.c ${WRKDIR}/*.h ${WRKSRC}/plugins
 	@${MKDIR} ${WRKSRC}/bcf-score
 	@${CP} ${WRKDIR}/*.R ${WRKSRC}/bcf-score
 
 # One .so for each .c in the score distfile
 do-install:
 	${MKDIR} ${STAGEDIR}${PREFIX}/libexec/bcftools
 	${INSTALL_PROGRAM} ${WRKSRC}/plugins/blup.so \
 		${STAGEDIR}${PREFIX}/libexec/bcftools
 	${INSTALL_PROGRAM} ${WRKSRC}/plugins/liftover.so \
 		${STAGEDIR}${PREFIX}/libexec/bcftools
 	${INSTALL_PROGRAM} ${WRKSRC}/plugins/metal.so \
 		${STAGEDIR}${PREFIX}/libexec/bcftools
 	${INSTALL_PROGRAM} ${WRKSRC}/plugins/munge.so \
 		${STAGEDIR}${PREFIX}/libexec/bcftools
 	${INSTALL_PROGRAM} ${WRKSRC}/plugins/pgs.so \
 		${STAGEDIR}${PREFIX}/libexec/bcftools
 	${INSTALL_PROGRAM} ${WRKSRC}/plugins/score.so \
 		${STAGEDIR}${PREFIX}/libexec/bcftools
 	(cd ${WRKSRC}/bcf-score && ${COPYTREE_SHARE} . ${STAGEDIR}${DATADIR})
 
 .include <bsd.port.mk>
diff --git a/biology/bcf-score/distinfo b/biology/bcf-score/distinfo
index fb0644c4567b..724198c182f2 100644
--- a/biology/bcf-score/distinfo
+++ b/biology/bcf-score/distinfo
@@ -1,5 +1,5 @@
-TIMESTAMP = 1727475307
+TIMESTAMP = 1750428714
 SHA256 (score_1.20-20240505.tar.gz) = c2ac510f0a48e3d2e61d1a9e219e030b1268cdcf3bf987217bbd16740d962d41
 SIZE (score_1.20-20240505.tar.gz) = 96852
-SHA256 (samtools-bcftools-1.20-1.21_GH0.tar.gz) = 7484695c5d833fb1a89c2b886ec302db0514ba3c8e5ef7397b9302fa8bd37f8d
-SIZE (samtools-bcftools-1.20-1.21_GH0.tar.gz) = 3665160
+SHA256 (samtools-bcftools-1.20-1.22_GH0.tar.gz) = 1608e547daf7bd5ab7d52dea57019f57da3fdfb29bc26dece1e8d01a999a9a2d
+SIZE (samtools-bcftools-1.20-1.22_GH0.tar.gz) = 3751342