diff --git a/accessibility/py-atspi/Makefile b/accessibility/py-atspi/Makefile
index dc149505de90..3ed1a77e3390 100644
--- a/accessibility/py-atspi/Makefile
+++ b/accessibility/py-atspi/Makefile
@@ -1,25 +1,24 @@
 PORTNAME=	atspi
-DISTVERSION=	2.46.1
+DISTVERSION=	2.58.1
 CATEGORIES=	accessibility x11-toolkits python
 MASTER_SITES=	GNOME
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	pyatspi-${DISTVERSION}
 DIST_SUBDIR=	gnome
 
 MAINTAINER=	gnome@FreeBSD.org
 COMMENT=	Python API for the D-BUS based SPI framework
 WWW=		https://gitlab.gnome.org/GNOME/pyatspi2
 
 LICENSE=	LGPL20
 
 RUN_DEPENDS=	${LOCALBASE}/libexec/at-spi2-registryd:accessibility/at-spi2-core
 
-CONFLICTS=	at-spi-1.[0-9]*
-PORTSCOUT=	limitw:1,even
-
-USES=		gettext gmake gnome localbase pkgconfig python tar:xz
+USES=		gnome localbase meson pkgconfig python tar:xz
+USE_GNOME=	pygobject3
 USE_PYTHON=	flavors py3kplist
-USE_GNOME=	intlhack pygobject3
-GNU_CONFIGURE=	yes
+BINARY_ALIAS=	python3=${PYTHON_CMD}
+
+PORTSCOUT=	limitw:1,even
 
 .include <bsd.port.mk>
diff --git a/accessibility/py-atspi/distinfo b/accessibility/py-atspi/distinfo
index 6180c6ba6c97..7c4f208df49a 100644
--- a/accessibility/py-atspi/distinfo
+++ b/accessibility/py-atspi/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1744215080
-SHA256 (gnome/pyatspi-2.46.1.tar.xz) = f91f6a57434e9c07d13d5c4bf819dd78e8ee605aac2ae45d8c64c28114fb041b
-SIZE (gnome/pyatspi-2.46.1.tar.xz) = 323392
+TIMESTAMP = 1768668112
+SHA256 (gnome/pyatspi-2.58.1.tar.xz) = 3f1f079935f926584331025c7531858deb42245c993b65121f4f4b01e6b04536
+SIZE (gnome/pyatspi-2.58.1.tar.xz) = 82620
diff --git a/accessibility/py-atspi/pkg-plist b/accessibility/py-atspi/pkg-plist
index c868ff4020cd..fcbe1416ea7f 100644
--- a/accessibility/py-atspi/pkg-plist
+++ b/accessibility/py-atspi/pkg-plist
@@ -1,72 +1,24 @@
 %%PYTHON_SITELIBDIR%%/pyatspi/Accessibility.py
-%%PYTHON_SITELIBDIR%%/pyatspi/Accessibility.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/Accessibility.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/__init__.py
-%%PYTHON_SITELIBDIR%%/pyatspi/__init__.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/__init__.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/action.py
-%%PYTHON_SITELIBDIR%%/pyatspi/action.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/action.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/appevent.py
-%%PYTHON_SITELIBDIR%%/pyatspi/appevent.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/appevent.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/application.py
-%%PYTHON_SITELIBDIR%%/pyatspi/application.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/application.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/atspienum.py
-%%PYTHON_SITELIBDIR%%/pyatspi/atspienum.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/atspienum.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/collection.py
-%%PYTHON_SITELIBDIR%%/pyatspi/collection.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/collection.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/component.py
-%%PYTHON_SITELIBDIR%%/pyatspi/component.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/component.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/constants.py
-%%PYTHON_SITELIBDIR%%/pyatspi/constants.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/constants.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/deviceevent.py
-%%PYTHON_SITELIBDIR%%/pyatspi/deviceevent.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/deviceevent.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/document.py
-%%PYTHON_SITELIBDIR%%/pyatspi/document.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/document.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/editabletext.py
-%%PYTHON_SITELIBDIR%%/pyatspi/editabletext.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/editabletext.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/hypertext.py
-%%PYTHON_SITELIBDIR%%/pyatspi/hypertext.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/hypertext.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/image.py
-%%PYTHON_SITELIBDIR%%/pyatspi/image.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/image.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/interface.py
-%%PYTHON_SITELIBDIR%%/pyatspi/interface.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/interface.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/registry.py
-%%PYTHON_SITELIBDIR%%/pyatspi/registry.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/registry.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/role.py
-%%PYTHON_SITELIBDIR%%/pyatspi/role.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/role.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/selection.py
-%%PYTHON_SITELIBDIR%%/pyatspi/selection.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/selection.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/state.py
-%%PYTHON_SITELIBDIR%%/pyatspi/state.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/state.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/table.py
-%%PYTHON_SITELIBDIR%%/pyatspi/table.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/table.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/tablecell.py
-%%PYTHON_SITELIBDIR%%/pyatspi/tablecell.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/tablecell.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/text.py
-%%PYTHON_SITELIBDIR%%/pyatspi/text.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/text.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/utils.py
-%%PYTHON_SITELIBDIR%%/pyatspi/utils.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/utils.pyo
 %%PYTHON_SITELIBDIR%%/pyatspi/value.py
-%%PYTHON_SITELIBDIR%%/pyatspi/value.pyc
-%%PYTHON_SITELIBDIR%%/pyatspi/value.pyo