diff --git a/devel/py-QtPy/Makefile b/devel/py-QtPy/Makefile
index 2925dc9f40cc..ae8cf7aec05c 100644
--- a/devel/py-QtPy/Makefile
+++ b/devel/py-QtPy/Makefile
@@ -1,19 +1,19 @@
 PORTNAME=	QtPy
-DISTVERSION=	1.11.3
+DISTVERSION=	2.2.1
 CATEGORIES=	devel python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Abstraction layer on top of the various Qt bindings
 WWW=		https://github.com/spyder-ide/qtpy
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 USES=		python:3.6+
-USE_PYTHON=	distutils autoplist
+USE_PYTHON=	distutils autoplist pytest # tests fail to run, see https://github.com/spyder-ide/qtpy/issues/370
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/devel/py-QtPy/distinfo b/devel/py-QtPy/distinfo
index 577139fc7142..dcd315097c7c 100644
--- a/devel/py-QtPy/distinfo
+++ b/devel/py-QtPy/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1638895938
-SHA256 (QtPy-1.11.3.tar.gz) = d427addd37386a8d786db81864a5536700861d95bf085cb31d1bea855d699557
-SIZE (QtPy-1.11.3.tar.gz) = 39637
+TIMESTAMP = 1665177220
+SHA256 (QtPy-2.2.1.tar.gz) = 7d5231133b772e40b4ee514b6673aca558331e4b88ca038b26c9e16c5c95524f
+SIZE (QtPy-2.2.1.tar.gz) = 52207