diff --git a/devel/py-msgspec/Makefile b/devel/py-msgspec/Makefile
index 9839190487bc..4f3b1bd01254 100644
--- a/devel/py-msgspec/Makefile
+++ b/devel/py-msgspec/Makefile
@@ -1,32 +1,32 @@
 PORTNAME=	msgspec
-PORTVERSION=	0.20.0
+PORTVERSION=	0.21.1
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Fast serialization and validation library
 WWW=		https://jcristharif.com/msgspec/ \
 		https://github.com/jcrist/msgspec
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=61:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools-scm>=8:devel/py-setuptools-scm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	autoplist concurrent pep517
 
 OPTIONS_DEFINE=	TOML YAML
 OPTIONS_DEFAULT=TOML YAML
 
 TOML_RUN_DEPENDS=	${PY_TOMLI} \
 			${PYTHON_PKGNAMEPREFIX}tomli-w>=0:textproc/py-tomli-w@${PY_FLAVOR}
 YAML_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pyyaml>=0:devel/py-pyyaml@${PY_FLAVOR}
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/devel/py-msgspec/distinfo b/devel/py-msgspec/distinfo
index fb25baec91bf..826902861683 100644
--- a/devel/py-msgspec/distinfo
+++ b/devel/py-msgspec/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1764510954
-SHA256 (msgspec-0.20.0.tar.gz) = 692349e588fde322875f8d3025ac01689fead5901e7fb18d6870a44519d62a29
-SIZE (msgspec-0.20.0.tar.gz) = 317862
+TIMESTAMP = 1777252648
+SHA256 (msgspec-0.21.1.tar.gz) = 2313508e394b0d208f8f56892ca9b2799e2561329de9763b19619595a6c0f72c
+SIZE (msgspec-0.21.1.tar.gz) = 319193
diff --git a/devel/py-msgspec/files/patch-pyproject.toml b/devel/py-msgspec/files/patch-pyproject.toml
index 322a7f058df7..b985a8114ae7 100644
--- a/devel/py-msgspec/files/patch-pyproject.toml
+++ b/devel/py-msgspec/files/patch-pyproject.toml
@@ -1,22 +1,22 @@
---- pyproject.toml.orig	2025-11-24 03:44:10 UTC
+--- pyproject.toml.orig	2026-04-12 21:33:59 UTC
 +++ pyproject.toml
 @@ -1,6 +1,6 @@ requires = [
  [build-system]
  requires = [
 -  "setuptools>=80",
 +  "setuptools>=61",
    "setuptools-scm>=8",
  ]
  build-backend = "setuptools.build_meta"
 @@ -12,10 +12,7 @@ readme = "README.md"
  ]
  description = "A fast serialization and validation library, with builtin support for JSON, MessagePack, YAML, and TOML."
  readme = "README.md"
 -license = "BSD-3-Clause"
 -license-files = [
 -  "LICENSE",
 -]
 +license = {text = "BSD-3-Clause"}
- requires-python = ">=3.9"
+ requires-python = ">=3.10"
  maintainers = [
    { name = "Jim Crist-Harif", email = "jcristharif@gmail.com" },